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    Chemistry

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    Also known as: 1092939-17-7, Jakafi, (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate, Jakavi, Ruxolitinib (phosphate), Ruxolitinib monophosphate
    Molecular Formula
    C17H21N6O4P
    Molecular Weight
    404.4  g/mol
    InChI Key
    JFMWPOCYMYGEDM-XFULWGLBSA-N
    FDA UNII
    436LRU32H5
    Ruxolitinib Phosphate
    Ruxolitinib Phosphate is the phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.
    1 2D Structure

    Ruxolitinib Phosphate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile;phosphoric acid
    2.1.2 InChI
    InChI=1S/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/m1./s1
    2.1.3 InChI Key
    JFMWPOCYMYGEDM-XFULWGLBSA-N
    2.1.4 Canonical SMILES
    C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O
    2.1.5 Isomeric SMILES
    C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O
    2.2 Other Identifiers
    2.2.1 UNII
    436LRU32H5
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 3r)-3-cyclopentyl-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)pyrazol-1-yl)propanenitrile

    2. Inc-424

    3. Inc424

    4. Inca24

    5. Incb-018424

    6. Incb-018424 Phosphate

    7. Incb-018424 Salt

    8. Incb-18424

    9. Incb-18424 Phosphate

    10. Incb018424

    11. Incb018424 Phosphate

    12. Jakafi

    13. Jakavi

    14. Opzelura

    15. Ruxolitinib

    16. Ruxolitinib (as Phosphate)

    17. Ruxolitinib Monophosphate

    2.3.2 Depositor-Supplied Synonyms

    1. 1092939-17-7

    2. Jakafi

    3. (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile Phosphate

    4. Jakavi

    5. Ruxolitinib (phosphate)

    6. Ruxolitinib Monophosphate

    7. Incb018424 Phosphate

    8. Ruxolitinib (as Phosphate)

    9. Incb-018424 Phosphate

    10. Incb-018424 Salt

    11. Ruxolitinib Phosphate [usan]

    12. Incb-18424 Phosphate

    13. Incb018424 Salt

    14. Chebi:66917

    15. 436lru32h5

    16. 1092939-17-7 (phosphate)

    17. (betar)-beta-cyclopentyl-4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazole-1-propanenitrile Phosphate

    18. Incb-18424

    19. Ruxolitinib Phosphate Salt

    20. (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile Phosphate

    21. (3r)-3-cyclopentyl-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1h-pyrazol-1-yl)propanenitrile Phosphate (1:1)

    22. Phosphenoperoxoic Acid Compound With (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)- 1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile And Dihydrogen (1:1:1)

    23. Opzelura

    24. Unii-436lru32h5

    25. (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrilephosphoricacid

    26. Jakafi (tn)

    27. Jakavi (tn)

    28. Ruxolitinib Phosphate(incb018424)

    29. Inc 424 Phosphate

    30. Incb 018424 Phosphate

    31. Incb-424

    32. Schembl1369365

    33. Chembl1795071

    34. Amy5620

    35. Dtxsid00911086

    36. Ruxolitinib Phosphate (jan/usan)

    37. Ruxolitinib Phosphate [mi]

    38. Ruxolitinib Phosphate [jan]

    39. Ex-a2660

    40. Cs1956

    41. Mfcd18452860

    42. S5243

    43. Akos024464417

    44. Ruxolitinib (incb-18424) Phosphate

    45. Ruxolitinib Phosphate [who-dd]

    46. Bcp9000783

    47. Ccg-268687

    48. Cs-0326

    49. 1h-pyrazole-1-propanenitrile, Beta-cyclopentyl-4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-,(betar)-, Phosphate (1:1)

    50. Ac-30901

    51. As-74723

    52. Hy-50858

    53. Ruxolitinib Phosphate [orange Book]

    54. Ruxolitinib (as Phosphate) [ema Epar]

    55. D09960

    56. J-501793

    57. Q27135517

    58. (3r)-3-cyclopentyl-3-(4-{7h-pyrrolo[2,3-d]pyrimidin-4-yl}-1h-pyrazol-1-yl)propanenitrile; Phosphoric Acid

    59. (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile;phosphoric Acid

    60. (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrilephosphate

    61. 1h-pyrazole-1-propanenitrile,.beta.-cyclopentyl-4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-,(.beta.r)-,phosphate (1:1)

    62. Phosphoric Acid--3-cyclopentyl-3-[4-(1h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile (1/1)

    2.4 Create Date
    2009-01-19
    3 Chemical and Physical Properties
    Molecular Weight 404.4 g/mol
    Molecular Formula C17H21N6O4P
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count4
    Exact Mass404.13619017 g/mol
    Monoisotopic Mass404.13619017 g/mol
    Topological Polar Surface Area161 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity503
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameJakafi
    PubMed HealthRuxolitinib (By mouth)
    Drug ClassesAntineoplastic Agent
    Active IngredientRuxolitinib phosphate
    Dosage FormTablet
    RouteOral
    Strengtheq 5mg base; eq 20mg base; eq 15mg base; eq 10mg base; eq 25mg base
    Market StatusPrescription
    CompanyIncyte

    2 of 2  
    Drug NameJakafi
    PubMed HealthRuxolitinib (By mouth)
    Drug ClassesAntineoplastic Agent
    Active IngredientRuxolitinib phosphate
    Dosage FormTablet
    RouteOral
    Strengtheq 5mg base; eq 20mg base; eq 15mg base; eq 10mg base; eq 25mg base
    Market StatusPrescription
    CompanyIncyte

    4.2 Drug Indication

    * Myelofibrosis (MF):

    Jakavi is indicated for the treatment of disease related splenomegaly or symptoms in adult patients with primary myelofibrosis (also known as chronic idiopathic myelofibrosis), post polycythaemia vera myelofibrosis or post essential thrombocythaemia myelofibrosis.

    * Polycythaemia vera (PV):

    Jakavi is indicated for the treatment of adult patients with polycythaemia vera who are resistant to or intolerant of hydroxyurea.

    * Graft versus host disease (GvHD):

    Jakavi is indicated for the treatment of patients aged 12 years and older with acute graft versus host disease or chronic graft versus host disease who have inadequate response to corticosteroids or other systemic therapies (see section 5. 1).

    Treatment of chronic Graft versus Host Disease (cGvHD)

    Treatment of acute graft-versus-host disease (aGvHD)

    Treatment of vitiligo

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    L01EJ01

    API Reference Price

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AP","supplier":"MSN LABORATORIES PRIVATE LTD","supplierCountry":"INDIA","foreign_port":"SAO PAULO - CONGONHA","customer":"LIBBS FARMACEUTICA LTDA","customerCountry":"BRAZIL","quantity":"0.40","actualQuantity":"0.4","unit":"KGS","unitRateFc":"21000","totalValueFC":"8357.9","currency":"USD","unitRateINR":1880550,"date":"22-Dec-2025","totalValueINR":"752220","totalValueInUsd":"8357.9","indian_port":"Hyderabad Air","hs_no":"29337990","bill_no":"416","productDescription":"API","marketType":"","country":"BRAZIL","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"MSN HOUSE, PLOT NO. C-24,, HYDERABAD. AP","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1643308200,"product":"RUXOLITINIB BASE, RUXOLITINIB(BETAR)-BETA-CYCLOPENTYL-4-(7H-PYRROLO(2,3-D)PYRIMIDIN-4-YL)-1H-PYRAZOLE-1-PROPANENITRILE","address":"H.NO. 8-2-337, BESIDE TV9 OFFICE, ROAD NO.3, BANJARA HILLS, Contact N","city":"HYDERABAD","supplier":"DFM INTERNATIONAL LTD","supplierCountry":"CHINA","foreign_port":"PADANG","customer":"DR REDDY'S LABORATORIES","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"25000","totalValueFC":"126353.4","currency":"USD","unitRateINR":"1882500","date":"28-Jan-2022","totalValueINR":"9412500","totalValueInUsd":"126353.4","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"7276662","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"PADANG","supplierAddress":"","customerAddress":"H.NO. 8-2-337, BESIDE TV9 OFFICE, ROAD NO.3, BANJARA HILLS, Contact N"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1645813800,"product":"RUXOLITINIB (PHOSPHATE)","address":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK","city":"KURLA, MUMBAI","supplier":"MEDCHEMEXPRESS LLC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"PIRAMAL PHARMA LTD","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"557.2","totalValueFC":"2826.5","currency":"USD","unitRateINR":"42373.2","date":"26-Feb-2022","totalValueINR":"211866","totalValueInUsd":"2826.5","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29420090","bill_no":"1000800","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"1 DEERPARK DR STE Q PRINCETON, NJ 08852","customerAddress":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1678386600,"product":"RUXOLITINIB PHOSPHATE","address":"H.NO. 8-2-337, BESIDE TV9 OFFICE, ROAD NO.3, BANJARA HILLS, Contact N","city":"HYDERABAD","supplier":"CHANGZHOU PHARMACEUTICAL FACTORY","supplierCountry":"CHINA","foreign_port":"NA","customer":"DR REDDY'S LABORATORIES","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"35000","totalValueFC":"35531.8","currency":"USD","unitRateINR":"2922500","date":"10-Mar-2023","totalValueINR":"2922500","totalValueInUsd":"35531.8","indian_port":"HYDERABAD AIR","hs_no":"29335990","bill_no":"4989820","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"H.NO. 8-2-337, BESIDE TV9 OFFICE, ROAD NO.3, BANJARA HILLS, Contact N"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1737657000,"product":"RUXOLITINIB PHOSPHATE INN RUXOLITINIB PHOSPHATE INN","address":"PLOT NO.2, MAITRIVIHAR,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"NANTONG CHANYOO PHARMATECH CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"AUROBINDO PHARMA LTD","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"14000","totalValueFC":"14141.4","currency":"USD","unitRateINR":"1219400","date":"24-Jan-2025","totalValueINR":"1219400","totalValueInUsd":"14141.4","indian_port":"Hyderabad Air","hs_no":"29335990","bill_no":"7964023","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"NO: 2 TONGHAI SI ROAD YANGKOU CHEMI CAL INDUSTRIAL PARK RUDONG COASTAL ECONOMIC DEVELOPMENT ZONE CHINA","customerAddress":"PLOT NO.2, MAITRIVIHAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1746469800,"product":"RUXOLITINIB PHOSPHATE (MATERIAL RETURN TO VENDOR AGAINST INVNO1905245129DT 28.06.24,1905245099DT17.06.24) 45\/2017-CUS","address":"MSN HOUSE, PLOT NO. C-24,","city":"HYDERABAD. AP","supplier":"MYLAN LABORATORIES LTD FDF UNIT 3","supplierCountry":"INDIA","foreign_port":"INDORE(EPZ\/SEZ)","customer":"MSN LABORATORIES PRIVATE LTD","customerCountry":"INDIA","quantity":"40.00","actualQuantity":"40","unit":"KGS","unitRateFc":"23483.3","totalValueFC":"943185.3","currency":"USD","unitRateINR":"2009000","date":"06-May-2025","totalValueINR":"80360000","totalValueInUsd":"943185.3","indian_port":"Indore-EPZ\/SEZ","hs_no":"29337990","bill_no":"9890481","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"INDORE(EPZ\/SEZ)","supplierAddress":"Plot No 11,12 & 13, SEZ Phase II ISEZ, Sector 3,Pithampur, Dist Dhar SDNF India","customerAddress":"MSN HOUSE, PLOT NO. C-24,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1749234600,"product":"DEURUXOLITINIB PHOSPHATE API, BATCH NO-0000162499 DEURUXOLITINIB PHOSPHATE API, BATCH NO-0000162499","address":"ACME PLAZA, ANDHERI KURLA ROAD,","city":"MUMBAI, MAHARASHTRA.","supplier":"OHM LABORATORIES INC","supplierCountry":"UNITED STATES","foreign_port":"NEWARK, NJ","customer":"SUN PHARMACEUTICAL INDUSTRIES LTD","customerCountry":"INDIA","quantity":"15.00","actualQuantity":"15","unit":"KGS","unitRateFc":"32164","totalValueFC":"487089.2","currency":"USD","unitRateINR":"2790222.6","date":"07-Jun-2025","totalValueINR":"41853339.42","totalValueInUsd":"487089.2","indian_port":"Delhi Air","hs_no":"29335990","bill_no":"2525947","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEWARK, NJ","supplierAddress":"14 TERMINAL ROAD, NORTHBRUNSWICK (N J), 08901 NEWJERSEY, USA SDNF U.S.A.","customerAddress":"ACME PLAZA, ANDHERI KURLA ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1754073000,"product":"RUXOLITINIB PHOSPHATE BATCH NO - RUXO-202210001 RUXOLITINIB PHOSPHATE BATCH NO - RUXO-202210001","address":"705, Kailash Corporate Lounge, Vikhroli, ,? Hiranandani Link Road, , ,? Vikhroli W , ?MUMBAI ,? MAHARASHTRA,? 400076","city":"","supplier":"LOTUS PHARMACEUTICAL CO LTD","supplierCountry":"TAIWAN","foreign_port":"TAIPEI","customer":"MEISHI PHARMA SERVICES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"1.80","actualQuantity":"1.8","unit":"KGS","unitRateFc":"27487.6","totalValueFC":"49070.7","currency":"USD","unitRateINR":"2385919.3","date":"02-Aug-2025","totalValueINR":"4294654.77","totalValueInUsd":"49070.7","indian_port":"Hyderabad Air","hs_no":"29222990","bill_no":"3648017","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TAIPEI","supplierAddress":"NO.30 CHENGGONG 1ST RD SINSING VILLAGE NANTOU CITY NANTOU COUNTY 540 TAIWAN TAIWAN","customerAddress":"705, Kailash Corporate Lounge, Vikhroli, ,? Hiranandani Link Road, , ,? Vikhroli W , ?MUMBAI ,? MAHARASHTRA,? 400076"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q3","strtotime":1754073000,"product":"RUXOLITINIB PHOSPHATE CAS. NO: 1092939-17-7 RUXOLITINIB PHOSPHATE CAS. NO: 1092939-17-7","address":"705, Kailash Corporate Lounge, Vikhroli, ,? Hiranandani Link Road, , ,? Vikhroli W , ?MUMBAI ,? MAHARASHTRA,? 400076","city":"","supplier":"CHONGQING HUAPONT PHARM CO LTD","supplierCountry":"CHINA","foreign_port":"CHONGQING","customer":"MEISHI PHARMA SERVICES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"14000","totalValueFC":"69424.4","currency":"USD","unitRateINR":"1215200","date":"02-Aug-2025","totalValueINR":"6076000","totalValueInUsd":"69424.4","indian_port":"Hyderabad Air","hs_no":"29335990","bill_no":"3650733","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHONGQING","supplierAddress":"NO. 69, XINGGUANG AVENUE, RENHE TOWN, YUBEI DISTRICT, CHONGQING CHINA","customerAddress":"705, Kailash Corporate Lounge, Vikhroli, ,? Hiranandani Link Road, , ,? Vikhroli W , ?MUMBAI ,? MAHARASHTRA,? 400076"}]
    18-Jan-2022
    22-Dec-2025
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

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    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    FDF Dossiers

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    01

    NanoAlvand

    Iran
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    IPPE
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothNanoAlvand is the entrance to Global Markets as a trusted Highly Potent Products manufacturer.

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    Regulatory Info :

    Registration Country : Iran

    Ruxolitinib Phosphate

    Brand Name : Relata

    Dosage Form : Tablet

    Dosage Strength : 5MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Iran

    NanoAlvand

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    02

    NanoAlvand

    Iran
    arrow
    IPPE
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothNanoAlvand is the entrance to Global Markets as a trusted Highly Potent Products manufacturer.

    Contact Supplier Contact Supplier
    Flag Iran
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Iran

    Ruxolitinib Phosphate

    Brand Name : Relata

    Dosage Form : Tablet

    Dosage Strength : 10MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Iran

    NanoAlvand

    Portfolio PDF

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    03

    NanoAlvand

    Iran
    arrow
    IPPE
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothNanoAlvand is the entrance to Global Markets as a trusted Highly Potent Products manufacturer.

    Contact Supplier Contact Supplier
    Flag Iran
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Iran

    Ruxolitinib Phosphate

    Brand Name : Relata

    Dosage Form : Tablet

    Dosage Strength : 15MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Iran

    NanoAlvand

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

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    Corporate PDF

    04

    NanoAlvand

    Iran
    arrow
    IPPE
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothNanoAlvand is the entrance to Global Markets as a trusted Highly Potent Products manufacturer.

    Contact Supplier Contact Supplier
    Flag Iran
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Iran

    Ruxolitinib Phosphate

    Brand Name : Relata

    Dosage Form : Tablet

    Dosage Strength : 20MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Iran

    NanoAlvand

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    Digital Content

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    Corporate PDF

    05

    Apotex Inc

    Canada
    IPPE
    Not Confirmed
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    Apotex Inc

    Canada
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    IPPE
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Flag Canada
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    Regulatory Info :

    Registration Country : USA

    Ruxolitinib

    Brand Name : Ruxolitinib

    Dosage Form : TABLET; ORAL

    Dosage Strength : 10MG

    Packaging :

    Approval Date :

    Application Number : 219660

    Regulatory Info :

    Registration Country : USA

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    06

    Incyte Corporation

    U.S.A
    IPPE
    Not Confirmed
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    Incyte Corporation

    U.S.A
    arrow
    IPPE
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Flag U.S.A
    Virtual Booth Virtual Booth
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    Regulatory Info : RX

    Registration Country : USA

    RUXOLITINIB PHOSPHATE

    Brand Name : JAKAFI

    Dosage Form : TABLET;ORAL

    Dosage Strength : EQ 5MG BASE

    Packaging :

    Approval Date : 2011-11-16

    Application Number : 202192

    Regulatory Info : RX

    Registration Country : USA

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    07

    Incyte Corporation

    U.S.A
    IPPE
    Not Confirmed
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    Incyte Corporation

    U.S.A
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    IPPE
    Not Confirmed
    • fda
    • EDQM
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    Virtual Booth Virtual Booth
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    Regulatory Info : RX

    Registration Country : USA

    RUXOLITINIB PHOSPHATE

    Brand Name : JAKAFI

    Dosage Form : TABLET;ORAL

    Dosage Strength : EQ 10MG BASE

    Packaging :

    Approval Date : 2011-11-16

    Application Number : 202192

    Regulatory Info : RX

    Registration Country : USA

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    08

    Incyte Corporation

    U.S.A
    IPPE
    Not Confirmed
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    Incyte Corporation

    U.S.A
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    IPPE
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Flag U.S.A
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    Regulatory Info : RX

    Registration Country : USA

    RUXOLITINIB PHOSPHATE

    Brand Name : JAKAFI

    Dosage Form : TABLET;ORAL

    Dosage Strength : EQ 15MG BASE

    Packaging :

    Approval Date : 2011-11-16

    Application Number : 202192

    Regulatory Info : RX

    Registration Country : USA

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    09

    Incyte Corporation

    U.S.A
    IPPE
    Not Confirmed
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    Incyte Corporation

    U.S.A
    arrow
    IPPE
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Flag U.S.A
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : RX

    Registration Country : USA

    RUXOLITINIB PHOSPHATE

    Brand Name : JAKAFI

    Dosage Form : TABLET;ORAL

    Dosage Strength : EQ 20MG BASE

    Packaging :

    Approval Date : 2011-11-16

    Application Number : 202192

    Regulatory Info : RX

    Registration Country : USA

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    10

    Incyte Corporation

    U.S.A
    IPPE
    Not Confirmed
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    Incyte Corporation

    U.S.A
    arrow
    IPPE
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Flag U.S.A
    Virtual Booth Virtual Booth
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    Regulatory Info : RX

    Registration Country : USA

    RUXOLITINIB PHOSPHATE

    Brand Name : JAKAFI

    Dosage Form : TABLET;ORAL

    Dosage Strength : EQ 25MG BASE

    Packaging :

    Approval Date : 2011-11-16

    Application Number : 202192

    Regulatory Info : RX

    Registration Country : USA

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    01

    Brand Name : Jakavi

    Ruxolitinib

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    HPCI India
    Not Confirmed

    Brand Name : Jakavi

    Switzerland
    arrow
    HPCI India
    Not Confirmed

    Novartis

    Ruxolitinib

    Main Therapeutic Indication : Oncology

    Currency : USD

    2020 Revenue in Millions : 1,339

    2019 Revenue in Millions : 1,114

    Growth (%) : 20

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    02

    Brand Name : Jakavi

    Ruxolitinib

    arrow
    HPCI India
    Not Confirmed

    Brand Name : Jakavi

    Switzerland
    arrow
    HPCI India
    Not Confirmed

    Novartis

    Ruxolitinib

    Main Therapeutic Indication : Oncology

    Currency : USD

    2021 Revenue in Millions : 1,595

    2020 Revenue in Millions : 1,339

    Growth (%) : 19

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    03

    Brand Name : Jakavi

    Ruxolitinib

    arrow
    HPCI India
    Not Confirmed

    Brand Name : Jakavi

    Switzerland
    arrow
    HPCI India
    Not Confirmed

    Novartis

    Ruxolitinib

    Main Therapeutic Indication : Hematology

    Currency : USD

    2022 Revenue in Millions : 1,561

    2021 Revenue in Millions : 1,595

    Growth (%) : -2

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    04

    Brand Name : Jakavi

    Ruxolitinib

    arrow
    HPCI India
    Not Confirmed

    Brand Name : Jakavi

    Switzerland
    arrow
    HPCI India
    Not Confirmed

    Novartis

    Ruxolitinib

    Main Therapeutic Indication : Oncology

    Currency : USD

    2023 Revenue in Millions : 1,720

    2022 Revenue in Millions : 1,561

    Growth (%) : 10

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    05

    Brand Name : Jakavi

    Ruxolitinib

    arrow
    HPCI India
    Not Confirmed

    Brand Name : Jakavi

    Switzerland
    arrow
    HPCI India
    Not Confirmed

    Novartis

    Ruxolitinib

    Main Therapeutic Indication : Oncology

    Currency : USD

    2024 Revenue in Millions : 1,936

    2023 Revenue in Millions : 1,720

    Growth (%) : 13

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    06

    Brand Name : Jakavi

    Ruxolitinib

    arrow
    HPCI India
    Not Confirmed

    Brand Name : Jakavi

    Switzerland
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    HPCI India
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    Main Therapeutic Indication : Oncology

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    2014 Revenue in Millions : 71.20%

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    Brand Name : Jakavi

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    Novartis

    Ruxolitinib

    Main Therapeutic Indication : Oncology

    Currency : USD

    2015 Revenue in Millions : 279

    2014 Revenue in Millions : 410

    Growth (%) : 47%

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    Switzerland
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    Novartis

    Ruxolitinib

    Main Therapeutic Indication : Oncology

    Currency : USD

    2016 Revenue in Millions : 581

    2015 Revenue in Millions : 410

    Growth (%) : 42

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    Brand Name : Jakavi

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    Switzerland
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    Novartis

    Ruxolitinib

    Main Therapeutic Indication : Oncology

    Currency : USD

    2017 Revenue in Millions : 777

    2016 Revenue in Millions : 581

    Growth (%) : 34

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    Brand Name : Jakavi

    Ruxolitinib

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    Switzerland
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    Novartis

    Ruxolitinib

    Main Therapeutic Indication : Oncology

    Currency : USD

    2018 Revenue in Millions : 977

    2017 Revenue in Millions : 777

    Growth (%) : 26%

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    Ruxolitinib API needed in Australia [ENA24890]
    A CDMO that focuses on tablets, capsules, non-sterile liquids and injectables is looking for suppliers of Ruxolitinib API for commercial purposes. The suppliers must support this enquiry with USDMF, GMP & CoA.
    23 Dec 2025

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    23 Dec 2025

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    23 Dec 2025

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    Ruxolitinib Phosphate (500 g - 1 kg) API needed in Israel [ENA22740]
    A CRO that focuses on the development of various finished formulations is looking for suppliers of Ruxolitinib Phosphate (500 g - 1 kg) API for development purposes. The suppliers must support this enquiry with CEP/ USDMF & CoA.
    22 Apr 2025

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    22 Apr 2025

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    22 Apr 2025

    turkeypng-1602828403png-1622460951png-1622462103.png
    Ruxolitinib Phosphate (15 kg) API needed in Turkey [ENA22182]
    A company that focuses on development and manufacturing of various finished formulations is looking for suppliers of Ruxolitinib Phosphate (15 kg) API for commercial purposes. The suppliers must support this enquiry with CEP, DMF, GMP & CoA.
    24 Feb 2025

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    24 Feb 2025

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    Ruxolitinib Phosphate (100 g) API needed in India [ENA20371]
    A company that focuses on development and manufacturing of various liquids, ointments, and personal care product is looking for suppliers of Ruxolitinib Phosphate (100 g) API for development purposes. The suppliers must support this enquiry with DMF & CoA.
    27 Aug 2024

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    27 Aug 2024

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    27 Aug 2024

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    Ruxolitinib Phosphate (1 kg) API needed in India [ENA20350]
    A company that focuses on development and manufacturing of various finished formulations is looking for suppliers of Ruxolitinib Phosphate (1 kg) API for development purposes. The suppliers must support this enquiry with CoA.
    24 Aug 2024

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    24 Aug 2024

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    24 Aug 2024

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    Ruxolitinib Phosphate API needed in India [ENA20193]
    A company that focuses on manufacturing of various injectables, tablets, capsules, syrups, eye drops & ointments is looking for suppliers of Ruxolitinib Phosphate API. The required quantity is 200 g for evaluation and 5 kg - 50 kg for commercial purposes. The suppliers must support this enquiry with DMF & CoA.
    05 Aug 2024

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    05 Aug 2024

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    Ruxolitinib Phosphate (MOQ) API needed in Taiwan [ENA19951]
    A biopharmaceutical company that focuses on development of topical new dosage form and non-viral gene delivery systems is looking for suppliers of Ruxolitinib Phosphate (MOQ) API for development purposes. The suppliers must support this enquiry with CoA.
    12 Jul 2024

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    12 Jul 2024

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    12 Jul 2024

    india-flag.png
    Ruxolitinib Phosphate (1 kg) API needed in India [ENA19775]
    A CRO that provides formulation and analytical development services for OSDs, parenteral and liquid orals is looking for suppliers of Ruxolitinib Phosphate (1 kg) API for both development & commercial purposes. The suppliers must support this enquiry with CEP/ USDMF & CoA.
    22 Jun 2024

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    22 Jun 2024

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    22 Jun 2024

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    Ruxolitinib API needed in Tunisia [ENA18201]
    A company that deals in various pharmaceutical products is looking for suppliers of Ruxolitinib API. The initial required quantity is 300 g for development & 2 kg for commercial purposes. The suppliers must support this enquiry with CoA.
    02 Oct 2023

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    02 Oct 2023

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    02 Oct 2023

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    Ruxolitinib Phosphate & Nilotinib APIs needed in India [ENA17533]
    A company based in India that focuses on the research, development and manufacturing of complex pharmaceutical products including solid oral dosages, topicals, injectables & ophthalmics is looking for suppliers of Ruxolitinib Phosphate & Nilotinib APIs for both development & commercial purposes. The suppliers must support this enquiry with open part DMF & CoA.
    12 Jul 2023

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    12 Jul 2023

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    12 Jul 2023

    Only 10 entries up to this point, click to access all click full view read-more
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    Patents & EXCLUSIVITIES

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    ABOUT THIS PAGE

    Looking for 1092939-17-7 / Ruxolitinib Phosphate API manufacturers, exporters & distributors?

    Ruxolitinib Phosphate manufacturers, exporters & distributors 1

    41

    PharmaCompass offers a list of Ruxolitinib Phosphate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ruxolitinib Phosphate manufacturer or Ruxolitinib Phosphate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ruxolitinib Phosphate manufacturer or Ruxolitinib Phosphate supplier.

    PharmaCompass also assists you with knowing the Ruxolitinib Phosphate API Price utilized in the formulation of products. Ruxolitinib Phosphate API Price is not always fixed or binding as the Ruxolitinib Phosphate Price is obtained through a variety of data sources. The Ruxolitinib Phosphate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Ruxolitinib Phosphate

    Synonyms

    1092939-17-7, Jakafi, (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate, Jakavi, Ruxolitinib (phosphate), Ruxolitinib monophosphate

    Cas Number

    1092939-17-7

    Unique Ingredient Identifier (UNII)

    436LRU32H5

    About Ruxolitinib Phosphate

    Ruxolitinib Phosphate is the phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.

    Jakavi Manufacturers

    A Jakavi manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Jakavi, including repackagers and relabelers. The FDA regulates Jakavi manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Jakavi API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Jakavi manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Jakavi Suppliers

    A Jakavi supplier is an individual or a company that provides Jakavi active pharmaceutical ingredient (API) or Jakavi finished formulations upon request. The Jakavi suppliers may include Jakavi API manufacturers, exporters, distributors and traders.

    click here to find a list of Jakavi suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Jakavi USDMF

    A Jakavi DMF (Drug Master File) is a document detailing the whole manufacturing process of Jakavi active pharmaceutical ingredient (API) in detail. Different forms of Jakavi DMFs exist exist since differing nations have different regulations, such as Jakavi USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Jakavi DMF submitted to regulatory agencies in the US is known as a USDMF. Jakavi USDMF includes data on Jakavi's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Jakavi USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Jakavi suppliers with USDMF on PharmaCompass.

    Jakavi KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Jakavi Drug Master File in Korea (Jakavi KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Jakavi. The MFDS reviews the Jakavi KDMF as part of the drug registration process and uses the information provided in the Jakavi KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Jakavi KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Jakavi API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Jakavi suppliers with KDMF on PharmaCompass.

    Jakavi WC

    A Jakavi written confirmation (Jakavi WC) is an official document issued by a regulatory agency to a Jakavi manufacturer, verifying that the manufacturing facility of a Jakavi active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Jakavi APIs or Jakavi finished pharmaceutical products to another nation, regulatory agencies frequently require a Jakavi WC (written confirmation) as part of the regulatory process.

    click here to find a list of Jakavi suppliers with Written Confirmation (WC) on PharmaCompass.

    Jakavi NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Jakavi as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Jakavi API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Jakavi as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Jakavi and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Jakavi NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Jakavi suppliers with NDC on PharmaCompass.

    Jakavi GMP

    Jakavi Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Jakavi GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Jakavi GMP manufacturer or Jakavi GMP API supplier for your needs.

    Jakavi CoA

    A Jakavi CoA (Certificate of Analysis) is a formal document that attests to Jakavi's compliance with Jakavi specifications and serves as a tool for batch-level quality control.

    Jakavi CoA mostly includes findings from lab analyses of a specific batch. For each Jakavi CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Jakavi may be tested according to a variety of international standards, such as European Pharmacopoeia (Jakavi EP), Jakavi JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Jakavi USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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