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Inc.","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Public Offering","leadProduct":"Istaroxime","moa":"Sarcoplasmic\/endoplasmic reticulum calcium ATPase 2 | Sodium\/potassium-transporting ATPase","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase II","graph3":"Windtree Therapeutics","amount2":0.029999999999999999,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0.029999999999999999,"dosageForm":"Intravenous Infusion","sponsorNew":"Windtree Therapeutics \/ Oppenheimer & Co. Inc.","highestDevelopmentStatusID":"8","companyTruncated":"Windtree Therapeutics \/ Oppenheimer & Co. 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                          Peptide Process CMC
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                          Peptide Process CMC
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                          Details : Under the licensing agreement, Windtree will hold the exclusive rights of Phexxi (lactic acid, citric acid, and potassium bitartrate) vaginal gel. It is being indicated to prevent prgenancy.

                          Product Name : Phexxi

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          March 20, 2025

                          Lead Product(s) : L-Lactic Acid,Lactic Acid,Potassium Bitartrate

                          Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

                          Highest Development Status : Approved FDF

                          Recipient : Evofem Biosciences

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          02

                          Peptide Process CMC
                          Not Confirmed
                          Peptide Process CMC
                          Not Confirmed

                          Details : PST2744 (Istaroxime) is a Na/K ATPase 2 inhibitor, dual mechanism therapy designed to improve both systolic and diastolic cardiac function in patients with SCAI Stage C cardiogenic shock.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 30, 2024

                          Lead Product(s) : Istaroxime

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Peptide Process CMC
                          Not Confirmed
                          Peptide Process CMC
                          Not Confirmed

                          Details : PST2744 (Istaroxime) is a Na/K ATPase 2 inhibitor & SERCA2a activator, being developed for the treatment of early cardiogenic shock.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          September 30, 2024

                          Lead Product(s) : Istaroxime

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Peptide Process CMC
                          Not Confirmed
                          Peptide Process CMC
                          Not Confirmed

                          Details : Varian asset platform VAR-101 is a novel, potential high-potency, specific, aPKCi inhibitor with possible broad use in oncology as well as certain rare malignant diseases.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          August 04, 2024

                          Lead Product(s) : VAR-101

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : Varian Biopharmaceuticals

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          05

                          Peptide Process CMC
                          Not Confirmed
                          Peptide Process CMC
                          Not Confirmed

                          Details : PST2744 (istaroxime) is a first-in-class dual-mechanism therapy that is designed to improve systolic contraction and diastolic relaxation of the heart while also increasing blood pressure.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          July 25, 2024

                          Lead Product(s) : Istaroxime

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Peptide Process CMC
                          Not Confirmed
                          Peptide Process CMC
                          Not Confirmed

                          Details : PST2744 (Istaroxime) is a Na/K ATPase 2 inhibitor & SERCA2a activator, being developed for the treatment of early cardiogenic shock.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 09, 2024

                          Lead Product(s) : Istaroxime

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Peptide Process CMC
                          Not Confirmed
                          Peptide Process CMC
                          Not Confirmed

                          Details : PST2744 (Istaroxime) is a Na/K ATPase 2 inhibitor & first-in-class dual mechanism therapy, under Phase 2 clinical development for cardiogenic shock treatment.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 01, 2024

                          Lead Product(s) : Istaroxime

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Peptide Process CMC
                          Not Confirmed
                          Peptide Process CMC
                          Not Confirmed

                          Details : AEROSURF®, an acute pulmonary drug/device combo for premature infants with respiratory distress syndrome, has seen terminated rights.

                          Product Name : Aerosurf

                          Product Type : Peptide

                          Upfront Cash : Undisclosed

                          January 25, 2024

                          Lead Product(s) : Lucinactant

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase II

                          Recipient : Deerfield Management

                          Deal Size : Undisclosed

                          Deal Type : Termination

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                          09

                          Peptide Process CMC
                          Not Confirmed
                          Peptide Process CMC
                          Not Confirmed

                          Details : Under the agreement, Lee will develop and commercialize Windtree’s PST2744 (istaroxime), a first-in-class therapy for acute heart failure and cardiogenic shock in Greater China.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          January 17, 2024

                          Lead Product(s) : Istaroxime

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase II

                          Sponsor : Lee Pharma

                          Deal Size : $138.1 million

                          Deal Type : Licensing Agreement

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                          10

                          Peptide Process CMC
                          Not Confirmed
                          Peptide Process CMC
                          Not Confirmed

                          Details : The collaboration aims to research on PST2744 (istaroxime), a SERCA2a activator, an important target for the Company’s cardiovascular portfolio, including heart failure.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          January 02, 2024

                          Lead Product(s) : Istaroxime

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase II

                          Sponsor : Chang Gung University

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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