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    [{"orgOrder":0,"company":"Werewolf Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Protein","year":"2025","type":"Inapplicable","leadProduct":"WTX-330","moa":"IL-12 receptor","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Werewolf Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Werewolf Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"Werewolf Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Werewolf Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Protein","year":"2023","type":"Inapplicable","leadProduct":"WTX-330","moa":"IL-12 receptor","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Werewolf Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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    Find Clinical Drug Pipeline Developments & Deals by Werewolf Therapeutics

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                            01

                            Werewolf Therapeutics

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                            Lead Product(s) : WTX-330

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Phase 1b/2 Multisite Dose-finding and Expansion Study of WTX-330 in Adult Patients With Selected Advanced or...

                            Details : WTX-330 is a Protein drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            April 22, 2025

                            Lead Product(s) : WTX-330

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Werewolf Therapeutics

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                            Lead Product(s) : WTX-921

                            Therapeutic Area : Gastroenterology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Werewolf Introduces WTX-921, a First-in-Class IL-10 INDUKINE™ for Inflammatory Diseases

                            Details : WTX-921 is a novel IL-10 indukine development candidate for Inflammatory Bowel Disease (IBD) and potentially other inflammatory diseases.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 31, 2024

                            Lead Product(s) : WTX-921

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Werewolf Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : WTX-330

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Werewolf Highlights Data from Phase 1 Trial of WTX-330 for Tumors or Non-Hodgkin Lymphoma

                            Details : WTX-330 is designed to be a systemically dosed prodrug with the ability to deliver fully active IL-12 selectively. Currently, it is being evaluated for the treatment of neoplams.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            June 25, 2024

                            Lead Product(s) : WTX-330

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Werewolf Therapeutics

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                            AIChE Annual Meeting
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                            Werewolf Therapeutics

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                            Lead Product(s) : WTX-330

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Werewolf Therapeutics Announces Initiation of Patient Dosing in Phase 1 Study of WTX-330

                            Details : WTX-330 has the potential to be the only systemic, conditionally active IL-12 therapy with normal tissue IL-12R receptor blockade to deliver the full potency of IL-12 directly to the tumor microenvironment.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            February 24, 2023

                            Lead Product(s) : WTX-330

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Werewolf Therapeutics

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                            AIChE Annual Meeting
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                            Werewolf Therapeutics

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                            Lead Product(s) : WTX-330

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            WTX-330 in Patients With Advanced or Metastatic Solid Tumors or Non-Hodgkin Lymphoma

                            Details : WTX-330 is a Protein drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            January 10, 2023

                            Lead Product(s) : WTX-330

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Werewolf Therapeutics

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                            AIChE Annual Meeting
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                            Werewolf Therapeutics

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                            Lead Product(s) : WTX-330

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Werewolf Therapeutics Presents Preclinical Data on mWTX-330, a Surrogate IL-12 INDUKINE™ Molecule, at the So...

                            Details : Study data demonstrate that systemic administration of WTX-330, a mouse surrogate INDUKINE molecule, generates potent anti-tumor activity in a cleavage-dependent manner and protective memory against re-challenge in multiple murine syngeneic tumor models.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            November 10, 2022

                            Lead Product(s) : WTX-330

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Werewolf Therapeutics

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                            Werewolf Therapeutics

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                            Lead Product(s) : WTX-124,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Werewolf Therapeutics Announces Initiation of Patient Dosing in Phase 1/1b Clinical Trial of WTX-124 for the T...

                            Details : WTX-124 design consists of wild-type IL-2 cytokine tethered to an inactivation domain to prevent activation in off-target tissue, tumor protease-sensitive linker to allow for activation in tumor micro-environment and half-life extension domain to improve...

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            September 01, 2022

                            Lead Product(s) : WTX-124,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Werewolf Therapeutics

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                            AIChE Annual Meeting
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                            Werewolf Therapeutics

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                            Lead Product(s) : WTX-124

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Dose Escalation and Expansion Study of WTX-124 as Monotherapy and in Combination With Pembrolizumab (Pembro) i...

                            Details : WTX-124 is a Protein drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Neoplasm Metastasis.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            July 29, 2022

                            Lead Product(s) : WTX-124

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Werewolf Therapeutics

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                            AIChE Annual Meeting
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                            Werewolf Therapeutics

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                            Lead Product(s) : WTX-124,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Werewolf Therapeutics Presents Promising Preclinical Data on its Two Lead INDUKINE Molecules at AACR 2022 Annu...

                            Details : WTX-124 and WTX-330 INDUKINE molecules consist of wild-type IL-2 and IL-12 cytokines, tethered to an inactivation domain to prevent activation in peripheral tissue, to allow for activation in tumor microenvironment, and a half-life extension to improve t...

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            April 08, 2022

                            Lead Product(s) : WTX-124,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Merck & Co

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Werewolf Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : WTX-613

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Jazz Pharmaceuticals

                            Deal Size : $1,275.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Jazz Pharmaceuticals and Werewolf Therapeutics Announce Exclusive Global License and Collaboration Agreement t...

                            Details : Under the agreement, Jazz has acquired exclusive global development and commercialization rights to Werewolf's investigational WTX-613, a differentiated, conditionally-activated interferon alpha (IFNα) INDUKINE™ molecule in tumors.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : $15.0 million

                            April 07, 2022

                            Lead Product(s) : WTX-613

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Jazz Pharmaceuticals

                            Deal Size : $1,275.0 million

                            Deal Type : Licensing Agreement

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