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    [{"orgOrder":0,"company":"Verve Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2024","type":"Inapplicable","leadProduct":"VERVE-201","moa":"ANGPTL3","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"Verve Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Verve Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Verve Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Verve Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2022","type":"Inapplicable","leadProduct":"VERVE-201","moa":"ANGPTL3","graph1":"Cardiology\/Vascular 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Pharmaceuticals","highestDevelopmentStatusID":"2","companyTruncated":"Verve Therapeutics \/ Vertex Pharmaceuticals"}]

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                            01

                            Verve Therapeutics

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                            Lead Product(s) : VERVE-102

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Eli Lilly

                            Deal Size : $1,300.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Eli Lilly nears $1.3 billion deal for gene-editing biotech Verve Therapeutics

                            Details : Through the acquisition, Lilly will levrage Verve's pipeline of gene editing medicines, which includes VERVE-102, being evaluated for the treatment of Heterozygous Familial Hypercholesterolemia.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : $1,000.0 million

                            June 16, 2025

                            Lead Product(s) : VERVE-102

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Eli Lilly

                            Deal Size : $1,300.0 million

                            Deal Type : Acquisition

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                            02

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Discovery

                            Sponsor : Vertex Pharmaceuticals

                            Deal Size : $466.0 million

                            Deal Type : Termination

                            DEALS_DEV arrow-down

                            Vertex Axes Verve Gene Editing Pact Amid Shift in R&D Priorities

                            Details : Through the termination, Verve has now regained all rights to develop nonclinical-stage program, which is being evaluated for the treatment of Liver Disease.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : $60.0 million

                            February 27, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Discovery

                            Sponsor : Vertex Pharmaceuticals

                            Deal Size : $466.0 million

                            Deal Type : Termination

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                            03

                            Verve Therapeutics

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                            Lead Product(s) : VERVE-201

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia

                            Details : VERVE-201 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Hypercholesterolemia.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            June 11, 2024

                            Lead Product(s) : VERVE-201

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Verve Therapeutics

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                            Lead Product(s) : VERVE-102

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Verve Therapeutics Doses First Patient in Heart-2 Phase 1b Trial Of VERVE-102

                            Details : VERVE-102 is an investigational in vivo base editing drug aimed at inactivating PCSK9 gene in the liver, evaluated for heterozygous familial hypercholesterolemia & premature coronary artery disease.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            May 07, 2024

                            Lead Product(s) : VERVE-102

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Verve Therapeutics

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                            Lead Product(s) : VERVE-101

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Verve Halts Trial for Lead Gene Editing Program Due to Safety Concerns

                            Details : VERVE-101 is a PCSK9 gene editing program trial was halted, due to safety concerns occured in patients with heterozygous familial hypercholesterolemia.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            April 02, 2024

                            Lead Product(s) : VERVE-101

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

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                            Lead Product(s) : VERVE-102

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of VERVE-102 in Patients with Familial Hypercholesterolemia or Premature Coronary Artery Disease

                            Details : VERVE-102 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Heterozygous Familial Hypercholesterolemia.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            December 11, 2023

                            Lead Product(s) : VERVE-102

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Verve Therapeutics

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                            Lead Product(s) : VERVE-101

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Jefferies

                            Deal Size : $125.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Verve Therapeutics Announces Pricing of Public Offering of Common Stock and Concurrent Private Placement

                            Details : The net proceeds will fund the continued clinical development of VERVE-101 and preclinical and clinical development of VERVE-102 and VERVE-201, to conduct research and development activities.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Undisclosed

                            November 28, 2023

                            Lead Product(s) : VERVE-101

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Jefferies

                            Deal Size : $125.0 million

                            Deal Type : Public Offering

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                            08

                            Verve Therapeutics

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                            Lead Product(s) : VERVE-101

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Verve Therapeutics Announces Interim Data for VERVE-101 Demonstrating First Human Proof-of-Concept for In Vivo...

                            Details : VERVE-101 is an investigational, in vivo base editing medicine designed to be a single-course treatment that inactivates the PCSK9 gene in the liver to durably lower blood LDL-C. It is being evaluated for the treatment of heterozygous familial hyperchole...

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            November 12, 2023

                            Lead Product(s) : VERVE-101

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Verve Therapeutics

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                            Lead Product(s) : Lipoprotein

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Preclinical

                            Sponsor : Eli Lilly

                            Deal Size : $525.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Verve Establishes Global Collaboration with Lilly to Advance Verve’s In Vivo Gene Editing Program Targeting ...

                            Details : Under the terms of the collaboration, Verve will advance the research and development of its preclinical stage in vivo gene editing program targeting lipoprotein(a), an LDL-like particle with apolipoprotein B covalently linked to apolipoprotein(a).

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : $60.0 million

                            June 15, 2023

                            Lead Product(s) : Lipoprotein

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Eli Lilly

                            Deal Size : $525.0 million

                            Deal Type : Collaboration

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                            Lead Product(s) : VERVE-101

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Verve Therapeutics Announces VERVE-101 Awarded Innovation Passport by the UK MHRA for the Treatment of Heteroz...

                            Details : VERVE-101 is a novel, investigational gene editing medicine that permanently turns off the PCSK9 gene in the liver to reduce disease-driving LDL-C. It is being developed initially as a treatment for patients with heterozygous familial hypercholesterolemi...

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            February 15, 2023

                            Lead Product(s) : VERVE-101

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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