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                          01

                          CRS
                          Not Confirmed
                          CRS
                          Not Confirmed

                          Details : In the Phase 1b dose escalation, the 1st two dose levels have been cleared for safety; the 3rd dose level is enrolling; the maximum tolerated dose has not been reached to-date.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 28, 2020

                          Lead Product(s) : Onvansertib,Bevacizumab,Irinotecan Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          CRS
                          Not Confirmed
                          CRS
                          Not Confirmed

                          Details : Onvansertib demonstrates efficacy in Zytiga®-resistant metastatic castration-resistant prostate cancer (mCRPC) across known androgen receptor resistance mechanisms.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 13, 2020

                          Lead Product(s) : Onvansertib,Abiraterone Acetate,Prednisone

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          CRS
                          Not Confirmed
                          CRS
                          Not Confirmed

                          Details : The trial will evaluate the safety and efficacy of onvansertib in combination with standard-of-care FOLFIRI and Avastin® (bevacizumab).

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 21, 2020

                          Lead Product(s) : Onvansertib,Bevacizumab,Irinotecan Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          CRS
                          Not Confirmed
                          CRS
                          Not Confirmed

                          Details : Data presented at the ASCO-GI meeting in late January showed the effectiveness of onvansertib against all prevalent KRAS mutations associated with mCRC

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 04, 2020

                          Lead Product(s) : Onvansertib,Bevacizumab,Irinotecan Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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