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Life Sciences","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"UNITED KINGDOM","productType":"Antibody, Unconjugated","year":"2024","type":"Inapplicable","leadProduct":"Foralumab","moa":"||T cell surface glycoprotein CD3","graph1":"Nutrition and Weight Loss","graph2":"Preclinical","graph3":"Tiziana Life Sciences","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Tiziana Life Sciences \/ Undisclosed","highestDevelopmentStatusID":"4","companyTruncated":"Tiziana Life Sciences \/ Undisclosed"},{"orgOrder":0,"company":"Tiziana Life Sciences","sponsor":"Tiziana Life Sciences","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2024","type":"Inapplicable","leadProduct":"Foralumab","moa":"T cell surface glycoprotein 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                          01

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : The DoD award will support a three-year study of intranasal anti-CD3, foralumab, in the acute phase of spinal cord injury.

                          Product Name : TZLS-401

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Undisclosed

                          September 15, 2025

                          Lead Product(s) : Foralumab

                          Therapeutic Area : Trauma (Emergency, Injury, Surgery)

                          Highest Development Status : Preclinical

                          Sponsor : Department of Defense

                          Deal Size : Undisclosed

                          Deal Type : Funding

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                          02

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : TZLS-401 (foralumab) is world’s only fully human anti-CD3 monoclonal antibody administered intranasally is being investigated for the treatment of moderate Alzheimer's disease.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          May 09, 2025

                          Lead Product(s) : Foralumab

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : TZLS-401 (foralumab) is world’s only fully human anti-CD3 monoclonal antibody administered intranasally is being investigated for the treatment of non-active secondary progressive multiple sclerosis.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          May 06, 2025

                          Lead Product(s) : Foralumab

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Anti-CD3 antibody TZLS-401 intranasal foralumab, a fully human, anti-CD3 monoclonal antibody, being developed for non-active secondary progressive multiple sclerosis.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          April 23, 2025

                          Lead Product(s) : Foralumab

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Anti-CD3 antibody TZLS-401 intranasal foralumab, a fully human, anti-CD3 monoclonal antibody, being developed for non-active secondary progressive multiple sclerosis.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          April 02, 2025

                          Lead Product(s) : Foralumab

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Anti-CD3 antibody TZLS-401 intranasal foralumab, a fully human, anti-CD3 monoclonal antibody, being developed for non-active secondary progressive multiple sclerosis.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          March 25, 2025

                          Lead Product(s) : Foralumab

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Foralumab is a Antibody drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Multiple Sclerosis, Chronic Progressive.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          March 24, 2025

                          Lead Product(s) : Foralumab

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Foralumab is a Antibody drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          March 17, 2025

                          Lead Product(s) : Foralumab

                          Therapeutic Area : Undisclosed

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Anti-CD3 antibody TZLS-401 intranasal foralumab, a fully human, anti-CD3 monoclonal antibody, being developed for amyotrophic lateral sclerosis.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          March 04, 2025

                          Lead Product(s) : Foralumab

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : The collaboration aims to optimize the current formulation and develop a comprehensive plan for the scale-up of foralumab in a nasal device.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Undisclosed

                          February 21, 2025

                          Lead Product(s) : Foralumab

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Renaissance Pharma

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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