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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          March 07, 2025

                          Lead Product(s) : Ublituximab

                          Therapeutic Area : Neurology

                          Highest Development Status : Undisclosed

                          Recipient : University of Maryland, Baltimore

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Under the licensing agreement, TG Therapeutics obtains commercial rights to use MaxCyte’s Flow Electroporation® technology and ExPERT™ platform.

                          Product Name : Azer-cel

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          February 12, 2025

                          Lead Product(s) : Azercabtagene Zapreleucel

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Recipient : MaxCyte

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          03

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : TG Therapeutics received exclusive worldwide rights to develop and commercialize Azercabtagene Zapreleucel (azer-cel), an allogeneic CD19 CAR T cell therapy for autoimmune diseases.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : $17.5 million

                          December 02, 2024

                          Lead Product(s) : Azercabtagene Zapreleucel

                          Therapeutic Area : Immunology

                          Highest Development Status : Preclinical

                          Recipient : Precision BioSciences

                          Deal Size : $305.5 million

                          Deal Type : Licensing Agreement

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                          04

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          November 08, 2024

                          Lead Product(s) : Azercabtagene Zapreleucel

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Azercabtagene Zapreleucel (azer-cel) is an allogeneic CD19 CAR T cell therapy, which is being investigated for progressive forms of multiple sclerosis.

                          Product Name : Azer-cel

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          September 08, 2024

                          Lead Product(s) : Azercabtagene Zapreleucel

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Precision BioSciences

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : TG will receive exclusive worldwide rights to develop and commercialize Azercabtagene Zapreleucel, an allogeneic CD19 CAR T cell therapy for autoimmune diseases and non-oncology indications.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : $7.5 million

                          September 01, 2024

                          Lead Product(s) : Azercabtagene Zapreleucel

                          Therapeutic Area : Immunology

                          Highest Development Status : Preclinical

                          Recipient : Precision BioSciences

                          Deal Size : $315.5 million

                          Deal Type : Licensing Agreement

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                          07

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Through agreement, Neuraxpharm will focus on the commercialization of Briumvi (ublituximab) in Europe, for the treatment of adults patients with relapsing forms of multiple sclerosis.

                          Product Name : Briumvi

                          Product Type : Antibody

                          Upfront Cash : $152.5 million

                          February 26, 2024

                          Lead Product(s) : Ublituximab

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved FDF

                          Sponsor : Neuraxpharm

                          Deal Size : $645.0 million

                          Deal Type : Agreement

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                          08

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          May 26, 2023

                          Lead Product(s) : Ublituximab

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Briumvi (Ublituximab-xiiy) is a novel monoclonal antibody that targets a unique epitope on CD20-expressing B-cells. Targeting CD20 using monoclonal antibodies has proven to be an important therapeutic approach for the management of autoimmune disorders, ...

                          Product Name : Briumvi

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          March 31, 2023

                          Lead Product(s) : Ublituximab

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Briumvi (Ublituximab-xiiy) is a novel monoclonal antibody that targets a unique epitope on CD20-expressing B-cells. Targeting CD20 using monoclonal antibodies has proven to be an important therapeutic approach for the management of autoimmune disorders, ...

                          Product Name : Briumvi

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          February 14, 2023

                          Lead Product(s) : Ublituximab

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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