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    [{"orgOrder":0,"company":"Talaris Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2022","type":"Inapplicable","leadProduct":"FCR001","moa":"Immune tolerance","graph1":"Immunology","graph2":"Phase III","graph3":"Talaris Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Talaris Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Talaris Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Talaris Therapeutics","sponsor":"Tourmaline Bio","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Merger","leadProduct":"TOUR006","moa":"IL-6 receptor","graph1":"Immunology","graph2":"Phase II","graph3":"Talaris 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    Find Clinical Drug Pipeline Developments & Deals by Talaris Therapeutics

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                            01

                            Talaris Therapeutics

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                            Talaris Therapeutics

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                            Lead Product(s) : TOUR006

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Tourmaline Bio

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Tourmaline Bio Announces Closing of Merger with Talaris Therapeutics and Concurrent Private Placement of $75 M...

                            Details : The combined company will focus on advancing Tourmaline’s lead program, TOUR006, a potentially best-in-class anti-IL-6 antibody, for the treatment of thyroid eye disease (TED) and atherosclerotic cardiovascular disease (ASCVD).

                            Product Name : TOUR006

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            October 19, 2023

                            Lead Product(s) : TOUR006

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Tourmaline Bio

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            02

                            Talaris Therapeutics

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                            American Thoracic Society
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                            Talaris Therapeutics

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                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Talaris Therapeutics Announces Plans to Explore Strategic Alternatives and Implements Restructuring Plan

                            Details : FCR001 has the potential to restore self-tolerance in patients suffering from scleroderma and other severe autoimmune diseases by eradicating diseased autoreactive cells and regenerating a new and healthy supply of immune cells.

                            Product Name : FCR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            February 16, 2023

                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Talaris Therapeutics

                            U.S.A arrow
                            American Thoracic Society
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                            Talaris Therapeutics

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                            American Thoracic Society
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                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Talaris Therapeutics Provides Update on FREEDOM-1 Phase 3 Clinical Trial

                            Details : The primary endpoint of FREEDOM-1 is the proportion of kidney transplant recipients treated with FCR001 who are free from chronic IS, without biopsy-proven acute rejection (BPAR), at month 24 post-transplant.

                            Product Name : FCR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            October 20, 2022

                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Talaris Therapeutics

                            U.S.A arrow
                            American Thoracic Society
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                            Talaris Therapeutics

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                            American Thoracic Society
                            Not Confirmed
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                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Talaris Therapeutics Presents Data on Mechanisms of FCR001 Activity to Induce Immune Tolerance

                            Details : The analysis identified a unique urinary cell mRNA signature that is consistent with immune quiescence as defined by the ratio of CTLA-4 to granzyme B mRNA, which is significantly higher in the FCR001 cohorts compared to the control cohorts.

                            Product Name : FCR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            July 11, 2022

                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Talaris Therapeutics

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                            American Thoracic Society
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                            Talaris Therapeutics

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                            Lead Product(s) : FCR001

                            Therapeutic Area : Immunology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Talaris Therapeutics Presents Additional Phase 2 Data and Analyses at American Transplant Congress 2022

                            Details : Real-world, retrospective analysis of Phase 2 patients versus matched controls finds FCR001-treated patients have improved kidney function and fewer cardiometabolic complications than patients on immunosuppression after 5 years.

                            Product Name : FCR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            July 06, 2022

                            Lead Product(s) : FCR001

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Talaris Therapeutics

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                            Talaris Therapeutics

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                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Talaris Therapeutics Provides FREEDOM-1 Phase 3 Clinical Update

                            Details : All FREEDOM-1 patients who received FCR001 (cryopreserved allogeneic stem cell therapy) at least three months prior to the data cutoff date have achieved and maintained >50% T-cell chimerism, a potential biomarker predictive of achieving tolerance.

                            Product Name : FCR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            June 30, 2022

                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Talaris Therapeutics

                            U.S.A arrow
                            American Thoracic Society
                            Not Confirmed

                            Talaris Therapeutics

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                            American Thoracic Society
                            Not Confirmed
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                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Talaris Therapeutics Presents Data on COVID-19 Outcomes Among Kidney Transplant Patients Treated with FCR001

                            Details : Result demonstrated, 26 of 37 LDKT recipients of FCR001 from Company’s Phase 2 study achieved durable chimerism and were able to discontinue and remain off all IS for the duration of follow-up, with a median follow-up of over six years.

                            Product Name : FCR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            June 04, 2022

                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Talaris Therapeutics

                            U.S.A arrow
                            American Thoracic Society
                            Not Confirmed

                            Talaris Therapeutics

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                            American Thoracic Society
                            Not Confirmed
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                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Talaris Therapeutics Announces Conference Call to Highlight Presentations at the American Transplant Congress ...

                            Details : FCR001 is a cryopreserved allogeneic stem cell therapy derived from mobilized peripheral blood of the kidney donor that is delivered as a single dose in kidney transplant recipients who received a non-myeloablative conditioning regimen.

                            Product Name : FCR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            January 06, 2022

                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Talaris Therapeutics

                            U.S.A arrow
                            American Thoracic Society
                            Not Confirmed

                            Talaris Therapeutics

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                            American Thoracic Society
                            Not Confirmed
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                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Talaris Therapeutics Presents High-Resolution Analysis of HLA Mismatching in Phase 2 Trial in Living Donor Kid...

                            Details : Analysis confirms FCR001 (Cryopreserved Allogeneic Stem Cell Therapy) induced durable tolerance in highly mismatched related and unrelated living donor kidney transplant recipients.

                            Product Name : FCR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            December 14, 2021

                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Talaris Therapeutics

                            U.S.A arrow
                            American Thoracic Society
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                            Talaris Therapeutics

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                            American Thoracic Society
                            Not Confirmed
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                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Talaris Therapeutics Announces Initiation of Phase 2 Clinical Trial of FCR001 in Delayed Tolerance Induction

                            Details : Company developed FCR001 investigational, allogeneic cell therapy to induce or restore patients’ immune tolerance who have previously received a kidney from a living donor.

                            Product Name : FCR001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            October 29, 2021

                            Lead Product(s) : FCR001

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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