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Find Clinical Drug Pipeline Developments & Deals by Sutro Biopharma
Sutro intends to use the net proceeds of this offering to fund research, clinical, and development of STRO-002 (Luveltamab Tazevibulin) with Neulasta for treating patients with FOLR1-expressed Ovarian Neoplasms.
Lead Product(s):
Luveltamab Tazevibulin,Pegfilgrastim
Under the licensing agreement, Ipsen has exclusive worldwide rights to develop and commercialize STRO-003, an ROR1 inhibitor currently undergoing clinical evaluation for the treatment of neoplasms.
Under the agreement, Vaxcyte obtains exclusive rights to independently develop and manufacture cell-free extract, a key component of the company’s 24-valent pneumococcal conjugate vaccine (PCV) franchise which includes VAX-24 and VAX-31.
Lead Product(s):
24-valent Pneumococcal Conjugate Vaccine
The financing will be used for the continued pipeline advancement and further development of its cell-free protein synthesis and site-specific conjugation technologies, including VAX-24, a Phase 3 ready, 24-valent next-generation pneumococcal conjugate vaccine.
Lead Product(s):
24-valent Pneumococcal Conjugate Vaccine
STRO-002 (luveltamab tazevibulin), is a best-in-class folate receptor alpha (FolRα)-targeting ADC, is being investigated in a phase 1 clinical trial for ovarian and endometrial cancers. FDA has also granted the fast track designation for STRO-002.
Sutro’s proprietary and integrated cell-free protein synthesis platform XpressCF® and site-specific conjugation platform XpressCF+™ led to the discovery of STRO-001 and STRO-002, Sutro’s first two internally-developed ADCs.
Vaxcyte’s lead candidate, VAX-24, is a 24-valent, broad-spectrum, carrier-sparing pneumococcal conjugate vaccine being developed for the prevention of invasive pneumococcal disease.
Lead Product(s):
24-valent Pneumococcal Conjugate Vaccine
Sutro has two wholly owned ADCs in the clinic—STRO-002, a folate receptor alpha (FolRα)-targeting ADC, in clinical studies for ovarian and endometrial cancers; and STRO-001, a CD74-targeting ADC, in clinical studies for B-cell malignancies.
Sutro has been primarily responsible for preclinical research and development, as well as manufacturing, of cytokine derivatives SP'482 (MK-1484), utilizing Sutro’s proprietary cell-free protein synthesis and site-specific conjugation platforms, XpressCF® and Xpress CF+®.
The collaboration leverages the unique cancer-fighting potential of iADCs as a novel modality, enabled by Sutro’s ability to engineer complex conjugated antibodies, and Astellas’ global oncology R&D expertise.
Lead Product(s):
Immunostimulatory Antibody-drug Conjugate
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