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    [{"orgOrder":0,"company":"Summit Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Inapplicable","leadProduct":"Carboplatin","moa":"||PD-1\/VEGF","graph1":"Oncology","graph2":"Phase III","graph3":"Summit Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Summit Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Summit Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Summit Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Public Offering","leadProduct":"Ivonescimab","moa":"||PD-1\/VEGF","graph1":"Oncology","graph2":"Phase III","graph3":"Summit Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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    Find Clinical Drug Pipeline Developments & Deals by Summit Therapeutics

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                            01

                            Summit Therapeutics

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                            Specialty & Agro Chemical
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                            Summit Therapeutics

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                            Lead Product(s) : Ivonescimab

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Recipient : Akeso

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Interim Analysis Shows Ivonescimab Outperforms Pembrolizumab in NSCLC

                            Details : Ivonescimab, known as SMT112 in Summit’s license territories and as AK112 in China and Australia, is a novel, potential first-in-class investigational bispecific antibody.

                            Product Name : AK112

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            April 25, 2025

                            Lead Product(s) : Ivonescimab

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Recipient : Akeso

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Summit Therapeutics

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                            Specialty & Agro Chemical
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                            Summit Therapeutics

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                            Specialty & Agro Chemical
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                            Lead Product(s) : Ivonescimab,Carboplatin,Paclitaxel

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Recipient : Akeso

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Ivonescimab Combo Shows PFS Superiority Over Tislelizumab in NSCLC Trial

                            Details : Ivonescimab, known as SMT112 in Summit’s license territories and as AK112 in China and Australia, is a novel, potential first-in-class investigational bispecific antibody.

                            Product Name : AK112

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            April 23, 2025

                            Lead Product(s) : Ivonescimab,Carboplatin,Paclitaxel

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Recipient : Akeso

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Summit Therapeutics

                            U.S.A arrow
                            Specialty & Agro Chemical
                            Not Confirmed

                            Summit Therapeutics

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                            Specialty & Agro Chemical
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                            Lead Product(s) : Ivonescimab,Brentuximab Vedotin

                            Therapeutic Area : Oncology

                            Study Phase : Undisclosed

                            Sponsor : Pfizer Inc

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Summit and Pfizer Collaborates to Explore Ivonescimab in Combination with Pfizer's ADCs

                            Details : Summit will provide AK112/SMT112 (ivonescimab), a novel global first-in-class PD-1/VEGF bi-specific immunotherapy, in combination with several of Pfizer's ADCs.

                            Product Name : SMT112

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            February 24, 2025

                            Lead Product(s) : Ivonescimab,Brentuximab Vedotin

                            Therapeutic Area : Oncology

                            Highest Development Status : Undisclosed

                            Sponsor : Pfizer Inc

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            04

                            Summit Therapeutics

                            U.S.A arrow
                            Specialty & Agro Chemical
                            Not Confirmed

                            Summit Therapeutics

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                            Specialty & Agro Chemical
                            Not Confirmed
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                            Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : $235.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Summit Therapeutics Raises $235 Million

                            Details : Summit intends to use the net proceeds to advance, in part, the clinical development of SMT112 (ivonescimab) for the treatment of EFGR-mutated non-small cell lung cancer.

                            Product Name : SMT112

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            December 09, 2024

                            Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : $235.0 million

                            Deal Type : Private Placement

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                            05

                            Summit Therapeutics

                            U.S.A arrow
                            Specialty & Agro Chemical
                            Not Confirmed

                            Summit Therapeutics

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                            Specialty & Agro Chemical
                            Not Confirmed
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                            Lead Product(s) : Ivonescimab

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : The University of Texas MD Anderson Cancer Center

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Summit Therapeutics and MD Anderson Collaborate to Accelerate Ivonescimab Development

                            Details : The collaboration aims to advance the clinical development of the company-lead product that targets PD-1/VEGF, SMT112 (ivonescimab) for treating patients with PD-L1-positive solid tumors.

                            Product Name : SMT112

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            July 25, 2024

                            Lead Product(s) : Ivonescimab

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : The University of Texas MD Anderson Cancer Center

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            06

                            Summit Therapeutics

                            U.S.A arrow
                            Specialty & Agro Chemical
                            Not Confirmed

                            Summit Therapeutics

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                            Specialty & Agro Chemical
                            Not Confirmed
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                            Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Ivonescimab Approved in China for EGFRm NSCLC Based on HARMONi-A Trial

                            Details : Ivonescimab, known as AK112 in China and Australia, is a novel, first-in-class, approved bispecific antibody blocking PD-1 with VEGF for treating EGFR-mutated, advanced non-squamous NSCLC.

                            Product Name : SMT112

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            May 31, 2024

                            Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Summit Therapeutics

                            U.S.A arrow
                            Specialty & Agro Chemical
                            Not Confirmed

                            Summit Therapeutics

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                            Specialty & Agro Chemical
                            Not Confirmed
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                            Lead Product(s) : Ivonescimab

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Ivonescimab Shows Superiority Over Pembrolizumab in NSCLC First-Line Treatment

                            Details : Ivonescimab, known as SMT112, is a novel, potential first-in-class investigational bispecific antibody inhibiting PD-1 with VEGF is being investiated for PD-L1-positive NSCLC.

                            Product Name : SMT112

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            May 30, 2024

                            Lead Product(s) : Ivonescimab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Summit Therapeutics

                            U.S.A arrow
                            Specialty & Agro Chemical
                            Not Confirmed

                            Summit Therapeutics

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                            Specialty & Agro Chemical
                            Not Confirmed
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                            Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : $200.0 million

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            Summit Raises $200 Million; Also Expands License Territories for Ivonescimab

                            Details : Summit will to advance the clinical development of SMT112 (ivonescimab), a novel, potential first-in-class investigational bispecific antibody, in non-small cell lung cancer (NSCLC).

                            Product Name : SMT112

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            March 06, 2024

                            Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : $200.0 million

                            Deal Type : Financing

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                            09

                            Summit Therapeutics

                            U.S.A arrow
                            Specialty & Agro Chemical
                            Not Confirmed

                            Summit Therapeutics

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                            Specialty & Agro Chemical
                            Not Confirmed
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                            Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Summit Therapeutics Announces First Patient Treated in Phase III HARMONi Clinical Trial Evaluating Ivonescimab...

                            Details : SMT112 (ivonescimab) is an investigational bispecific antibody which blocks PD-1 with the anti-angiogenesis effects associated with blocking VEGF into a single molecule. It is being investigated for EGFR mutated NSCLC.

                            Product Name : SMT112

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            September 05, 2023

                            Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Summit Therapeutics

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                            Specialty & Agro Chemical
                            Not Confirmed

                            Summit Therapeutics

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                            Specialty & Agro Chemical
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                            Lead Product(s) : Ivonescimab,Carboplatin,Paclitaxel

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Summit Therapeutics Announces Initial Indications for Clinical Trials for Ivonescimab (SMT112)

                            Details : SMT112 (ivonescimab) is a novel, potential first-in-class, investigational bispecific antibody combining the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects associated with blocking VEGF into a single molecule.

                            Product Name : SMT112

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            March 05, 2023

                            Lead Product(s) : Ivonescimab,Carboplatin,Paclitaxel

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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