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                          Top Deals by Deal Size (USD bn)

                          01

                          IOPC
                          Not Confirmed
                          IOPC
                          Not Confirmed

                          Details : Ivonescimab, known as SMT112 in Summit’s license territories and as AK112 in China and Australia, is a novel, potential first-in-class investigational bispecific antibody.

                          Product Name : AK112

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          April 25, 2025

                          Lead Product(s) : Ivonescimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Recipient : Akeso

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          IOPC
                          Not Confirmed
                          IOPC
                          Not Confirmed

                          Details : Ivonescimab, known as SMT112 in Summit’s license territories and as AK112 in China and Australia, is a novel, potential first-in-class investigational bispecific antibody.

                          Product Name : AK112

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          April 23, 2025

                          Lead Product(s) : Ivonescimab,Carboplatin,Paclitaxel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Recipient : Akeso

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          IOPC
                          Not Confirmed
                          IOPC
                          Not Confirmed

                          Details : Summit will provide AK112/SMT112 (ivonescimab), a novel global first-in-class PD-1/VEGF bi-specific immunotherapy, in combination with several of Pfizer's ADCs.

                          Product Name : SMT112

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          February 24, 2025

                          Lead Product(s) : Ivonescimab,Brentuximab Vedotin

                          Therapeutic Area : Oncology

                          Highest Development Status : Undisclosed

                          Sponsor : Pfizer Inc

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          04

                          IOPC
                          Not Confirmed
                          IOPC
                          Not Confirmed

                          Details : Summit intends to use the net proceeds to advance, in part, the clinical development of SMT112 (ivonescimab) for the treatment of EFGR-mutated non-small cell lung cancer.

                          Product Name : SMT112

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          December 09, 2024

                          Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : $235.0 million

                          Deal Type : Private Placement

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                          05

                          IOPC
                          Not Confirmed
                          IOPC
                          Not Confirmed

                          Lead Product(s) : Ivonescimab

                          Therapeutic Area : Oncology

                          Study Phase : Preclinical

                          Sponsor : The University of Texas MD Anderson Cancer Center

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

                          Details : The collaboration aims to advance the clinical development of the company-lead product that targets PD-1/VEGF, SMT112 (ivonescimab) for treating patients with PD-L1-positive solid tumors.

                          Product Name : SMT112

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          July 25, 2024

                          Lead Product(s) : Ivonescimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : The University of Texas MD Anderson Cancer Center

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          06

                          IOPC
                          Not Confirmed
                          IOPC
                          Not Confirmed

                          Details : Ivonescimab, known as AK112 in China and Australia, is a novel, first-in-class, approved bispecific antibody blocking PD-1 with VEGF for treating EGFR-mutated, advanced non-squamous NSCLC.

                          Product Name : SMT112

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          May 31, 2024

                          Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          IOPC
                          Not Confirmed
                          IOPC
                          Not Confirmed

                          Details : Ivonescimab, known as SMT112, is a novel, potential first-in-class investigational bispecific antibody inhibiting PD-1 with VEGF is being investiated for PD-L1-positive NSCLC.

                          Product Name : SMT112

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          May 30, 2024

                          Lead Product(s) : Ivonescimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          IOPC
                          Not Confirmed
                          IOPC
                          Not Confirmed

                          Details : Summit will to advance the clinical development of SMT112 (ivonescimab), a novel, potential first-in-class investigational bispecific antibody, in non-small cell lung cancer (NSCLC).

                          Product Name : SMT112

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          March 06, 2024

                          Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : $200.0 million

                          Deal Type : Financing

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                          09

                          IOPC
                          Not Confirmed
                          IOPC
                          Not Confirmed

                          Details : SMT112 (ivonescimab) is an investigational bispecific antibody which blocks PD-1 with the anti-angiogenesis effects associated with blocking VEGF into a single molecule. It is being investigated for EGFR mutated NSCLC.

                          Product Name : SMT112

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          September 05, 2023

                          Lead Product(s) : Ivonescimab,Carboplatin,Pemetrexed

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          IOPC
                          Not Confirmed
                          IOPC
                          Not Confirmed

                          Details : SMT112 (ivonescimab) is a novel, potential first-in-class, investigational bispecific antibody combining the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects associated with blocking VEGF into a single molecule.

                          Product Name : SMT112

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          March 05, 2023

                          Lead Product(s) : Ivonescimab,Carboplatin,Paclitaxel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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