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    [{"orgOrder":0,"company":"Spyre Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"SPY001","moa":"Alpha-4-beta-7 integrin","graph1":"Gastroenterology","graph2":"Phase II","graph3":"Spyre Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Spyre Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Spyre Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Spyre Therapeutics","sponsor":"Aeglea BioTherapeutics","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Miscellaneous","year":"2023","type":"Acquisition","leadProduct":"SPY001","moa":"Alpha-4-beta-7 integrin","graph1":"Gastroenterology","graph2":"Phase II","graph3":"Spyre Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Spyre Therapeutics \/ Aeglea BioTherapeutics","highestDevelopmentStatusID":"8","companyTruncated":"Spyre Therapeutics \/ Aeglea BioTherapeutics"},{"orgOrder":0,"company":"Spyre Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"SPY001","moa":"Alpha-4-beta-7 integrin","graph1":"Immunology","graph2":"Phase II","graph3":"Spyre Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Spyre Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Spyre Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Spyre Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2025","type":"Inapplicable","leadProduct":"SPY003","moa":"IL-23","graph1":"Gastroenterology","graph2":"Phase I","graph3":"Spyre Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Spyre Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Spyre Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Spyre Therapeutics","sponsor":"Altasciences Company Inc","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"SPY002-091","moa":"TL1A","graph1":"Undisclosed","graph2":"Phase I","graph3":"Spyre Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Inc","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"U.S.A","productType":"Undisclosed","year":"2024","type":"Inapplicable","leadProduct":"SPY001-001","moa":"Undisclosed","graph1":"Undisclosed","graph2":"Phase I","graph3":"Spyre Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Spyre Therapeutics \/ Altasciences Company Inc","highestDevelopmentStatusID":"6","companyTruncated":"Spyre Therapeutics \/ Altasciences Company Inc"},{"orgOrder":0,"company":"Spyre Therapeutics","sponsor":"Altasciences Company Inc","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"U.S.A","productType":"Undisclosed","year":"2024","type":"Inapplicable","leadProduct":"SPY002-072","moa":"Undisclosed","graph1":"Undisclosed","graph2":"Phase I","graph3":"Spyre Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Spyre Therapeutics \/ Altasciences Company Inc","highestDevelopmentStatusID":"6","companyTruncated":"Spyre Therapeutics \/ Altasciences Company Inc"},{"orgOrder":0,"company":"Spyre Therapeutics","sponsor":"Altasciences Company Inc","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"U.S.A","productType":"Undisclosed","year":"2025","type":"Inapplicable","leadProduct":"SPY003-207","moa":"Undisclosed","graph1":"Undisclosed","graph2":"Phase I","graph3":"Spyre Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Spyre Therapeutics \/ Altasciences Company Inc","highestDevelopmentStatusID":"6","companyTruncated":"Spyre Therapeutics \/ Altasciences Company Inc"},{"orgOrder":0,"company":"Spyre Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2025","type":"Inapplicable","leadProduct":"SPY072","moa":"VEGI","graph1":"Immunology","graph2":"Phase II","graph3":"Spyre Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Spyre Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Spyre Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Spyre Therapeutics","sponsor":"Jefferies | Leerink Partners | Stifel | Nicolaus & Company","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2025","type":"Public Offering","leadProduct":"SPY001","moa":"Alpha-4-beta-7 integrin","graph1":"Gastroenterology","graph2":"Phase II","graph3":"Spyre Therapeutics","amount2":0.28000000000000003,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Gastroenterology","amount2New":0.28000000000000003,"dosageForm":"Injection","sponsorNew":"Spyre Therapeutics \/ Jefferies | Leerink Partners | Stifel | Nicolaus & Company","highestDevelopmentStatusID":"8","companyTruncated":"Spyre Therapeutics \/ Jefferies | Leerink Partners | Stifel | Nicolaus & Company"}]

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                            01

                            Spyre Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : SPY001

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase II

                            Sponsor : Jefferies | Leerink Partners | Stifel | Nicolaus & Company

                            Deal Size : $275.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Spyre Therapeutics Prices $275.0M Public Offering of Common Stock

                            Details : The proceeds from the offering will used to fund the clinical development of SPY001, the focus is on targeting Alpha-4-beta-7 integrin for IBD treatment.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Undisclosed

                            October 13, 2025

                            Lead Product(s) : SPY001

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase II

                            Sponsor : Jefferies | Leerink Partners | Stifel | Nicolaus & Company

                            Deal Size : $275.0 million

                            Deal Type : Public Offering

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                            02

                            Spyre Therapeutics

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                            AIChE Annual Meeting
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                            AIChE Annual Meeting
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                            Lead Product(s) : SPY072

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of SPY072 in Rheumatic Disease

                            Details : SPY072 is a Antibody drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Arthritis, Rheumatoid.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            August 29, 2025

                            Lead Product(s) : SPY072

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Spyre Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : SPY001

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Long-acting Antibodies Alone or Combined in Ulcerative Colitis

                            Details : SPY001 is a Other Large Molecule drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Colitis, Ulcerative.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            June 10, 2025

                            Lead Product(s) : SPY001

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Spyre Therapeutics

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                            AIChE Annual Meeting
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                            Spyre Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : SPY003

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Spyre Doses First Participant In Phase 1 Trial Of SPY003 IL-23 Antibody

                            Details : SPY003 is an investigational half-life extended anti-IL-23 monoclonal antibody, which is currently being evaluated for the treatment of inflammatory bowel disease.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            March 27, 2025

                            Lead Product(s) : SPY003

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Spyre Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : SPY003-207

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Altasciences Company Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            SPY003-207 in Healthy Volunteers

                            Details : SPY003-207 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            March 13, 2025

                            Lead Product(s) : SPY003-207

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Altasciences Company Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Spyre Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : SPY002-091

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Spyre Starts Phase 1 Trials for Anti-TL1A Half-Life Extended Antibodies

                            Details : SPY002-091 is an investigational, extended half-life monoclonal antibody targeting TL1A for the potential treatment of inflammatory and fibrotic diseases including IBD.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 02, 2024

                            Lead Product(s) : SPY002-091

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Spyre Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : SPY002-091

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Altasciences Company Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of SPY002-091 in Healthy Volunteers

                            Details : SPY002-091 is a Other Large Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            November 04, 2024

                            Lead Product(s) : SPY002-091

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Altasciences Company Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Spyre Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : SPY002-072

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Altasciences Company Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of SPY002-072 in Healthy Volunteers

                            Details : SPY002-072 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            October 01, 2024

                            Lead Product(s) : SPY002-072

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Altasciences Company Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Spyre Therapeutics

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                            AIChE Annual Meeting
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                            Spyre Therapeutics

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                            Lead Product(s) : SPY001

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Spyre Doses First Patients in Phase 1 Trial, SPY001 for the Treatment of IBD

                            Details : SPY001 is an investigational novel half-life extended anti-α4β7 monoclonal antibody, which is being evaluated for the treatment of inflammatory bowel disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            June 18, 2024

                            Lead Product(s) : SPY001

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Spyre Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : SPY001-001

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Altasciences Company Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of SPY001-001 in Healthy Volunteers

                            Details : SPY001-001 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            June 07, 2024

                            Lead Product(s) : SPY001-001

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Altasciences Company Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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