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    [{"orgOrder":0,"company":"Silence Therapeutics","sponsor":"5Am Ventures","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"UNITED KINGDOM","productType":"Oligonucleotide","year":"2024","type":"Private Placement","leadProduct":"Zerlasiran","moa":"Lipoprotein","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase II","graph3":"Silence Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Silence Therapeutics \/ 5Am Ventures","highestDevelopmentStatusID":"8","companyTruncated":"Silence Therapeutics \/ 5Am Ventures"},{"orgOrder":0,"company":"Silence Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"UNITED 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    Find Clinical Drug Pipeline Developments & Deals by Silence Therapeutics

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                            01

                            Silence Therapeutics

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                            RDD 2025
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                            Silence Therapeutics

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                            Lead Product(s) : Divesiran

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Silence Therapeutics Reports Positive Results from Divesiran Phase 1 in Polycythemia Vera

                            Details : SLN124 (divesiran) is a short interfering RNA targeting TMPRSS6, which is being evaluated for the treatment of patients with polycythemia vera.

                            Product Name : SLN124

                            Product Type : Other Large Molecule

                            Upfront Cash : Inapplicable

                            June 27, 2024

                            Lead Product(s) : Divesiran

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Silence Therapeutics

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                            RDD 2025
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                            Silence Therapeutics

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                            RDD 2025
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Genetic Disease

                            Study Phase : Preclinical

                            Sponsor : Hansoh Pharma

                            Deal Size : $1,316.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Silence Therapeutics Achieves Research Milestone Payment from Hansoh Pharma Collaboration

                            Details : The collaboration aims to develop siRNAs leveraging Silence’s mRNAi GOLD platform for three undisclosed targets. Silence has exclusive rights to the first two targets in all territories except china.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : $16.0 million

                            June 24, 2024

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Preclinical

                            Sponsor : Hansoh Pharma

                            Deal Size : $1,316.0 million

                            Deal Type : Collaboration

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                            03

                            Silence Therapeutics

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                            RDD 2025
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                            Silence Therapeutics

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                            RDD 2025
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                            Lead Product(s) : Zerlasiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Silence's Zerlasiran Shows Positive 48-week Phase 2 Data

                            Details : SLN360 (zerlasiran) is a siRNA designed to lower the body’s production of Lp(a), it is being investigated in patients having risk of atherosclerotic cardiovascular disease (ASCVD) events.

                            Product Name : SLN360

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            June 20, 2024

                            Lead Product(s) : Zerlasiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Silence Therapeutics

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                            RDD 2025
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                            Silence Therapeutics

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                            RDD 2025
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                            Lead Product(s) : Zerlasiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : 5Am Ventures

                            Deal Size : $120.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Silence Therapeutics Announces Oversubscribed $120 Million Private Placement

                            Details : The company intends to use the net proceeds for the advancement of its ongoing clinical development for SLN360 (zerlasiran) for the treatment of atherosclerotic cardiovascular disease.

                            Product Name : SLN360

                            Product Type : Oligonucleotide

                            Upfront Cash : Undisclosed

                            May 02, 2024

                            Lead Product(s) : Zerlasiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : 5Am Ventures

                            Deal Size : $120.0 million

                            Deal Type : Private Placement

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                            05

                            Silence Therapeutics

                            United Kingdom arrow
                            RDD 2025
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                            Silence Therapeutics

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                            RDD 2025
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                            Lead Product(s) : Zerlasiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Silence Reports Positive 36-Week Data from Phase 2 Study of Zerlasiran

                            Details : SLN360 (zerlasiran) is a phase 2 siRNA designed to reduce Lp(a) production, a genetic risk factor for cardiovascular disease affecting 20% of the population.

                            Product Name : SLN360

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            March 13, 2024

                            Lead Product(s) : Zerlasiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Silence Therapeutics

                            United Kingdom arrow
                            RDD 2025
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                            Silence Therapeutics

                            United Kingdom arrow
                            RDD 2025
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : AstraZeneca

                            Deal Size : $570.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Silence Achieves $10 Million Milestone from AstraZeneca for Phase 1 Trial

                            Details : Silence and AstraZeneca will collaborate to use Silence’s mRNAi GOLD platform to develop siRNA therapeutics for various diseases, including cardiovascular and respiratory.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : $80.0 million

                            February 23, 2024

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : AstraZeneca

                            Deal Size : $570.0 million

                            Deal Type : Collaboration

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                            07

                            Silence Therapeutics

                            United Kingdom arrow
                            RDD 2025
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                            Silence Therapeutics

                            United Kingdom arrow
                            RDD 2025
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                            Lead Product(s) : Zerlasiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Silence Therapeutics Provides SLN360 and SLN124 Clinical Program Updates

                            Details : SLN360 is a gene ‘silencing’ therapy, designed to temporarily blocks LPA, a gene that tells the body to make a specific protein that is only found in Lp(a). As the levels of Lp(a) are lowered, which lowers the risk of heart diseases, heart attacks an...

                            Product Name : SLN360

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            December 01, 2023

                            Lead Product(s) : Zerlasiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Silence Therapeutics

                            United Kingdom arrow
                            RDD 2025
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                            Silence Therapeutics

                            United Kingdom arrow
                            RDD 2025
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Technology

                            Study Phase : Preclinical

                            Sponsor : Hansoh Pharma

                            Deal Size : $1,316.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Silence Therapeutics Achieves $4 Million in Research Milestone Payments from Hansoh Pharma Collaboration

                            Details : The collaboration aims to develop siRNAs (short interfering RNAs) leveraging Silence’s proprietary mRNAi GOLD™ platform for three undisclosed targets. Silence has exclusive rights to the first two targets in all territories except the China region.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : $16.0 million

                            November 07, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Technology

                            Highest Development Status : Preclinical

                            Sponsor : Hansoh Pharma

                            Deal Size : $1,316.0 million

                            Deal Type : Collaboration

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                            09

                            Silence Therapeutics

                            United Kingdom arrow
                            RDD 2025
                            Not Confirmed

                            Silence Therapeutics

                            United Kingdom arrow
                            RDD 2025
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Discovery Platform

                            Sponsor : AstraZeneca

                            Deal Size : $4,080.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Silence Therapeutics Achieves $10 Million Milestone Payment from AstraZeneca Collaboration

                            Details : Under the agreement, Silence and AstraZeneca is focused on using Silence’s proprietary mRNAi GOLD™ platform to develop siRNA therapeutics for cardiovascular, renal, metabolic and respiratory diseases.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : $80.0 million

                            April 05, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Discovery Platform

                            Sponsor : AstraZeneca

                            Deal Size : $4,080.0 million

                            Deal Type : Collaboration

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                            10

                            Silence Therapeutics

                            United Kingdom arrow
                            RDD 2025
                            Not Confirmed

                            Silence Therapeutics

                            United Kingdom arrow
                            RDD 2025
                            Not Confirmed
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                            Lead Product(s) : Zerlasiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Silence Therapeutics Announces Positive Topline Results from Phase 1 Multiple Dose Study of Zerlasiran in Subj...

                            Details : SLN360 (zerlasiran) is a siRNA (short interfering RNA) designed to lower the body’s production of lipoprotein(a), a key genetic risk factor for cardiovascular disease.

                            Product Name : SLN360

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            January 11, 2023

                            Lead Product(s) : Zerlasiran

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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