[{"orgOrder":0,"company":"Sigilon Therapeutics","sponsor":"Canada Pension Plan Investment Board ","pharmaFlowCategory":"D","amount":"$80.3 million","upfrontCash":"Undisclosed","newsHeadline":"Sigilon Therapeutics Announces $80.3 Million Series B Financing to Advance","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"IND Enabling","country":"U.S.A","productType":"Undisclosed","productStatus":"New Molecular Entity","date":"March 2020","year":"2020","type":"Series B Financing","leadProduct":"SIG-001","moa":"","url1":"","url2":"","graph1":"Genetic Disease","graph2":"IND Enabling","graph3":"Sigilon Therapeutics","amount2":0.080000000000000002,"therapeuticAreaNew":"Genetic Disease","highestDevelopmentStatusNew":"IND Enabling","highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Genetic Disease","productSubType":"","amount2New":0.080000000000000002,"dosageForm":"","sponsorNew":"Sigilon Therapeutics \/ Canada Pension Plan Investment Board ","highestDevelopmentStatusID":"5","companyTruncated":"Sigilon Th.."},{"orgOrder":0,"company":"Sigilon Therapeutics","sponsor":"Morgan Stanley","pharmaFlowCategory":"D","amount":"$100.0 million","upfrontCash":"Undisclosed","newsHeadline":"Chronic Disease Biotech Sigilon Therapeutics Files for a $100 Million IPO","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"Phase I\/ Phase II","country":"","productType":"Cell and Gene therapy","productStatus":"New Molecular Entity","date":"November 2020","year":"2020","type":"Public Offering","leadProduct":"SIG-001","moa":"","url1":"","url2":"","graph1":"Genetic Disease","graph2":"Phase I\/ Phase II","graph3":"Sigilon Therapeutics","amount2":0.10000000000000001,"therapeuticAreaNew":"Genetic Disease","highestDevelopmentStatusNew":"Phase I\/ Phase II","highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Genetic Disease","productSubType":"","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Sigilon 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Therapeutics","amount2":0.34000000000000002,"therapeuticAreaNew":"Endocrinology","highestDevelopmentStatusNew":"Preclinical","highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Endocrinology","productSubType":"","amount2New":0.34000000000000002,"dosageForm":"","sponsorNew":"Sigilon Therapeutics \/ Eli Lilly","highestDevelopmentStatusID":"4","companyTruncated":"Sigilon Th.."}]

Find Clinical Drug Pipeline Developments & Deals by Sigilon Therapeutics

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          BioProcess International
                          Not Confirmed
                          BioProcess International
                          Not Confirmed

                          Details : Through the acquisition, Lilly gains control of the partnered encapsulated cell therapies, including SIG-002 (human insulin), for the treatment of type 1 diabetes.

                          Brand Name : SIG-002

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $344.2 million

                          August 14, 2023

                          Lead Product(s) : SIG-002

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Preclinical

                          Sponsor : Eli Lilly

                          Deal Size : $344.2 million

                          Deal Type : Acquisition

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                          02

                          BioProcess International
                          Not Confirmed
                          BioProcess International
                          Not Confirmed

                          Details : Through the acquisition, Lilly will gain control of the partnered encapsulated cell therapies, including SIG-002 (human insulin), for the treatment of type 1 diabetes.

                          Brand Name : SIG-002

                          Molecule Type : Peptide

                          Upfront Cash : $344.2 million

                          June 29, 2023

                          Lead Product(s) : Insulin Lispro

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Discovery

                          Sponsor : Eli Lilly

                          Deal Size : $344.2 million

                          Deal Type : Acquisition

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                          03

                          BioProcess International
                          Not Confirmed
                          BioProcess International
                          Not Confirmed

                          Details : SIG-005 contains a human cell line genetically modified with a non-viral vector designed to express human a-L-iduronidase (IDUA), an enzyme which is missing or defective in patients with MPS-1.

                          Brand Name : SIG-005

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          January 31, 2022

                          Lead Product(s) : SIG-005

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          BioProcess International
                          Not Confirmed
                          BioProcess International
                          Not Confirmed

                          Details : Sigilon recently filed a Clinical Trial Application (CTA) in the United Kingdom for SIG-005 in MPS-1 and anticipates submitting an Investigational New Drug (IND) application and a CTA in the United States...

                          Brand Name : SIG-005

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          July 23, 2021

                          Lead Product(s) : SIG-005

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          BioProcess International
                          Not Confirmed
                          BioProcess International
                          Not Confirmed

                          Details : SIG-005 contains a human cell line genetically modified with a non-viral vector designed to express human a-L-iduronidase (IDUA), an enzyme which is missing or defective in patients with MPS-1.

                          Brand Name : SIG-005

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          December 17, 2020

                          Lead Product(s) : SIG-005

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          BioProcess International
                          Not Confirmed
                          BioProcess International
                          Not Confirmed

                          Details : Sigilon's lead candidate, SIG-001, is designed to prevent bleeding episodes in patients with Hemophilia A and recently began a Phase 1/2 trial.

                          Brand Name : SIG-001

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          November 13, 2020

                          Lead Product(s) : SIG-001

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Morgan Stanley

                          Deal Size : $100.0 million

                          Deal Type : Public Offering

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                          07

                          BioProcess International
                          Not Confirmed
                          BioProcess International
                          Not Confirmed

                          Details : The funding will support the first-in-human clinical trial of Sigilon’s novel encapsulated cell therapy for hemophilia A.

                          Brand Name : Undisclosed

                          Molecule Type : Undisclosed

                          Upfront Cash : Undisclosed

                          March 17, 2020

                          Lead Product(s) : SIG-001

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : IND Enabling

                          Sponsor : Canada Pension Plan Investment Board

                          Deal Size : $80.3 million

                          Deal Type : Series B Financing

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