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Undisclosed"},{"orgOrder":0,"company":"Sana Biotechnology","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2024","type":"Inapplicable","leadProduct":"SC291","moa":"CD19","graph1":"Immunology","graph2":"Phase I","graph3":"Sana Biotechnology","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Sana Biotechnology \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Sana Biotechnology \/ Undisclosed"},{"orgOrder":0,"company":"Sana Biotechnology","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2024","type":"Inapplicable","leadProduct":"Cyclophosphamide","moa":"||CD19","graph1":"Immunology","graph2":"Phase I","graph3":"Sana Biotechnology","amount2":0,"highestDevelopmentShortName":"Ph 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Find Clinical Drug Pipeline Developments & Deals by Sana Biotechnology

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : UP421 is an allogeneic, primary islet cell therapy engineered with Sana’s hypoimmune (HIP) technology, which is being evaluated for the treatment of patients with type 1 diabetes.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          January 07, 2025

                          Lead Product(s) : UP421

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : SC291 is a CD19-directed allogeneic CAR T cell therapy developed using Sana's hypoimmune platform for the treatment of relapsed/refractory systemic lupus erythematosus.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          December 02, 2024

                          Lead Product(s) : SC291,Cyclophosphamide,Fludarabine Phosphate

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : SC291 is a CD19-directed allogeneic CAR T cell therapy developed using Sana's hypoimmune platform for the treatment of B-cell mediated autoimmune diseases (AID).

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          November 04, 2024

                          Lead Product(s) : SC291,Cyclophosphamide,Fludarabine Phosphate

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : SC291 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Lupus Erythematosus, Systemic.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          March 05, 2024

                          Lead Product(s) : SC291

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : SC262 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Lymphoma, Non-Hodgkin.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          February 29, 2024

                          Lead Product(s) : SC262

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Proceeds will focus on developing SC291, an allogeneic CD19-directed CAR T cell therapy for relapsed/refractory B-cell malignancies, including Non-Hodgkin lymphoma & Chronic lymphocytic leukemia.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          February 12, 2024

                          Lead Product(s) : SC291

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Morgan Stanley

                          Deal Size : $189.7 million

                          Deal Type : Public Offering

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                          07

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Proceeds will focus on developing SC291, an allogeneic CD19-directed CAR T cell therapy for relapsed/refractory B-cell malignancies, including Non-Hodgkin lymphoma & Chronic lymphocytic leukemia.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          February 08, 2024

                          Lead Product(s) : SC291

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Morgan Stanley

                          Deal Size : $165.0 million

                          Deal Type : Public Offering

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                          08

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Proceeds will focus on developing SC291, an allogeneic CD19-directed CAR T cell therapy for relapsed/refractory B-cell malignancies, including Non-Hodgkin lymphoma & Chronic lymphocytic leukemia.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          February 07, 2024

                          Lead Product(s) : SC291

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Morgan Stanley

                          Deal Size : $125.0 million

                          Deal Type : Public Offering

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                          09

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : UP421 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Diabetes Mellitus, Type 1.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          February 02, 2024

                          Lead Product(s) : UP421

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase I

                          Recipient : Per-Ola Carlsson

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : SC262 is a hypoimmune, CD22-directed allogeneic CAR T cell therapy derived from healthy donor CD4+ and CD8+ T cells. It is under preclinical development for the treatment of patients with relapsed or refractory B-cell malignancies.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          December 05, 2023

                          Lead Product(s) : SC262

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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