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                          01

                          ACS GCI
                          Not Confirmed
                          ACS GCI
                          Not Confirmed

                          Details : PRAX-562 (relutrigine) is being evaluated in the mid-stage clinical trial for the treatment of patients suffering from SCN2A and SCN8A Encephalopathy.

                          Product Name : PRAX-562

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 18, 2024

                          Lead Product(s) : Relutrigine

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          ACS GCI
                          Not Confirmed
                          ACS GCI
                          Not Confirmed

                          Details : PRAX-562 (relutrigine) is being evaluated in the mid-stage clinical trial for the treatment of patients suffering from SCN2A and SCN8A Encephalopathy.

                          Product Name : PRAX-562

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 09, 2024

                          Lead Product(s) : Relutrigine

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          ACS GCI
                          Not Confirmed
                          ACS GCI
                          Not Confirmed

                          Details : PRAX-562 is a first-in-class small molecule in development for the treatment of DEEs as a preferential inhibitor of persistent sodium current, shown to be a key driver of seizure symptoms in early onset SCN2A-DEE and SCN8A-DEE.

                          Product Name : PRAX-562

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 28, 2022

                          Lead Product(s) : Relutrigine

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          ACS GCI
                          Not Confirmed
                          ACS GCI
                          Not Confirmed

                          Details : PRAX-562 is a first selective persistent sodium current blocker. Praxis plans to initiate a Phase 2 clinical trial in the first half of 2022 to explore the potential for PRAX-562 to treat a range of rare pediatric DEEs, including SCN2A-DEE and SCN8A-DEE.

                          Product Name : PRAX-562

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 30, 2021

                          Lead Product(s) : Relutrigine

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          ACS GCI
                          Not Confirmed
                          ACS GCI
                          Not Confirmed

                          Details : Praxis will utilize the Ciitizen platform to provide deeper insights across disease populations through the analysis of real-world data, initially to inform the development of PRAX-222 and PRAX-562 in SCN2A developmental and epileptic encephalopathy (SCN...

                          Product Name : PRAX-562

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 16, 2021

                          Lead Product(s) : Relutrigine

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Praxis Precision Medicines

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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