
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Pathos
Deal Size : Undisclosed
Deal Type : Acquisition
Pathos AI Completes Acquisition of Rain Oncology
Details : Through the acquisition of Rain Oncology, Pathos gains access to its product canditate RAIN-32 (milademetan), a small molecule, oral inhibitor of the p53-MDM2 complex that reactivates p53.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
January 26, 2024
Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Pathos
Deal Size : Undisclosed
Deal Type : Acquisition

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Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Pathos
Deal Size : Undisclosed
Deal Type : Acquisition
Details : Through the acquisition of Rain Oncology, Pathos gains access to its product canditate RAIN-32 (milademetan), a small molecule, oral inhibitor of the p53-MDM2 complex that reactivates p53.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
December 13, 2023
Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Pathos
Deal Size : Undisclosed
Deal Type : Acquisition

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Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Milademetan in Combination With Atezolizumab in Patients With Advanced Solid Tumors With CDKN2A Loss
Details : Milademetan is a Other Small Molecule drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Neoplasms.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
October 19, 2023
Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Study Phase : Phase II
Recipient : Institut Curie
Deal Size : Inapplicable
Deal Type : Inapplicable
Milademetan and Fulvestrant in GATA3-mutant, ER+HER- Advanced or Metastatic Breast Cancer
Details : Milademetan is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Breast Neoplasms.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
July 06, 2023
Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Highest Development Status : Phase II
Recipient : Institut Curie
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : RAIN-32 (milademetan) is an oral small molecule inhibitor of the p53-MDM2 complex that reactivates p53. It has demonstrated antitumor activity in an MDM2- amplified subtype of liposarcoma (LPS) and other solid tumors.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
May 30, 2023
Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : RAIN-32 (milademetan) is an oral small molecule inhibitor of the p53-MDM2 complex that reactivates p53. Milademetan has demonstrated antitumor activity in an MDM2- amplified subtype of liposarcoma (LPS) and other solid tumors.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
May 22, 2023
Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Milademetan
Therapeutic Area : Undisclosed
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
A Study of Milademetan Administration on Cardiac Repolarization in Healthy Subjects
Details : Milademetan is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
March 07, 2023
Lead Product(s) : Milademetan
Therapeutic Area : Undisclosed
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Phase 1 Clinical Data of Milademetan Published in Journal of Clinical Oncology
Details : RAIN-32 (milademetan) is an oral small molecule inhibitor of the p53-MDM2 complex that reactivates p53. Milademetan has demonstrated antitumor activity in an MDM2- amplified subtype of liposarcoma (LPS) and other solid tumors.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
January 23, 2023
Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Rain Therapeutics Announces a Poster Presentation at the 2022 San Antonio Breast Cancer Symposium
Details : Rain’s lead product, milademetan, is a small molecule, oral inhibitor of MDM2-p53 complex that reactivates p53. In addition to milademetan, Rain is also developing a preclinical program that is focused on inducing synthetic lethality in cancer cells by...
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
November 23, 2022
Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Rain’s lead product candidate, RAIN-32 (milademetan), an oral small molecule, inhibitor of mouse double minute 2 (MDM2) is being developed in patients with wildtype tumor protein 53 (p53) cancers that are also exhibiting MDM2 dependence.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
November 17, 2022
Lead Product(s) : Milademetan
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
