Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Endoxifen
Therapeutic Area : Oncology
Study Phase : Phase II
Recipient : Atossa Therapeutics
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Endoxifen (z-endoxifen) is the most active metabolite of the FDA approved selective estrogen receptor modulator (SERM), tamoxifen. It has demonstrated that the anti-estrogenic effects and is being evaluated for ER+/HER2+ breast cancer.
Product Name : (Z)-Endoxifen
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
June 28, 2023
Lead Product(s) : Endoxifen
Therapeutic Area : Oncology
Highest Development Status : Phase II
Recipient : Atossa Therapeutics
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Endoxifen
Therapeutic Area : Oncology
Study Phase : Phase II
Recipient : Atossa Therapeutics
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : (Z)-endoxifen is the most active metabolite of the FDA approved selective estrogen receptor modulator (SERM), tamoxifen. It has demonstrated that the anti-estrogenic effects and is being evaluated for ER+/HER2+ breast cancer.
Product Name : (Z)-Endoxifen
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 21, 2023
Lead Product(s) : Endoxifen
Therapeutic Area : Oncology
Highest Development Status : Phase II
Recipient : Atossa Therapeutics
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Evorpacept,Fam-trastuzumab Deruxtecan
Therapeutic Area : Oncology
Study Phase : Phase I
Recipient : ALX Oncology
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ALX148 (evorpacept), is a next generation CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated, proprietary Fc domain. It is being investigated in combination with enhertu for breast cancer.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
March 13, 2023
Lead Product(s) : Evorpacept,Fam-trastuzumab Deruxtecan
Therapeutic Area : Oncology
Highest Development Status : Phase I
Recipient : ALX Oncology
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Paclitaxel,Dostarlimab,Encequidar
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Athenex
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Oral paclitaxel, relative to intravenous paclitaxel, was associated with less neuropathy and was not associated with an increase in febrile neutropenia.
Product Name : Taxol
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
December 20, 2022
Lead Product(s) : Paclitaxel,Dostarlimab,Encequidar
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Athenex
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Narsoplimab
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Omeros
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : OMS721 (narsoplimab) was selected for inclusion in the I-SPY COVID Trial because of its demonstrated ability to inhibit complement activation, inflammation, and coagulation, the three components that characterize COVID-19.
Product Name : Undisclosed
Product Type : Antibody
Upfront Cash : Inapplicable
September 15, 2022
Lead Product(s) : Narsoplimab
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Omeros
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Narsoplimab
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Recipient : Omeros
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : OMS721 (narsoplimab) was not observed to shorten the time to recovery in critically ill patients with COVID-19 in this study. The study did not identify any new safety signals for narsoplimab in the setting of critically ill COVID-19 patients.
Product Name : Undisclosed
Product Type : Antibody
Upfront Cash : Inapplicable
September 15, 2022
Lead Product(s) : Narsoplimab
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Recipient : Omeros
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Evorpacept,Trastuzumab Deruxtecan
Therapeutic Area : Oncology
Study Phase : IND Enabling
Recipient : ALX Oncology
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The lead product candidate, evorpacept (ALX148), is a next generation CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated, proprietary Fc domain.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
August 15, 2022
Lead Product(s) : Evorpacept,Trastuzumab Deruxtecan
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Recipient : ALX Oncology
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Cyclosporine,Remdesivir
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : To minimize potential toxicity a relatively low oral dose of 5 mg/kg/day for a duration of 5 days was selected to be administered to patients randomized into the CSA (cyclosporine) arm.
Product Name : CsA
Product Type : Peptide
Upfront Cash : Inapplicable
August 08, 2022
Lead Product(s) : Cyclosporine,Remdesivir
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ARX788 is an anti-HER2 antibody drug conjugate (ADC), is a homogeneous and highly stable ADC that maximizes potential anti-tumor activity by optimizing the number and position of its payloads and the chemical bonds that conjugate the payloads to the anti...
Product Name : Undisclosed
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
April 25, 2022
Lead Product(s) : Aviptadil Acetate,Remdesivir
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Sponsor : NRx Pharmaceuticals
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Aviptadil is a synthetic form of Human Vasoactive Intestinal Polypeptide and was selected because of the potential to reduce inflammation and stabilize the air sacs of hospitalized because of injury from acute respiratory distress syndrome, which is the ...
Product Name : Zyesami
Product Type : Peptide
Upfront Cash : Inapplicable
March 31, 2022
Lead Product(s) : Aviptadil Acetate,Remdesivir
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Sponsor : NRx Pharmaceuticals
Deal Size : Inapplicable
Deal Type : Inapplicable