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    [{"orgOrder":0,"company":"Protalix BioTherapeutics","sponsor":"Chiesi Group","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"ISRAEL","productType":"Enzyme","year":"2023","type":"Inapplicable","leadProduct":"Pegunigalsidase Alpha","moa":"Alpha-galactosidase A","graph1":"Genetic Disease","graph2":"Approved FDF","graph3":"Protalix BioTherapeutics","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Protalix BioTherapeutics \/ Chiesi Group","highestDevelopmentStatusID":"15","companyTruncated":"Protalix BioTherapeutics \/ Chiesi Group"},{"orgOrder":0,"company":"Protalix BioTherapeutics","sponsor":"Chiesi Group","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"ISRAEL","productType":"Enzyme","year":"2023","type":"Inapplicable","leadProduct":"Pegunigalsidase Alpha","moa":"Alpha-galactosidase A","graph1":"Genetic Disease","graph2":"Approved 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I","therapeuticAreaShortName":"Rheumatology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Protalix BioTherapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Protalix BioTherapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Protalix BioTherapeutics","sponsor":"SarcoMed","pharmaFlowCategory":"D","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Agreement","leadProduct":"Alidornase Alpha","moa":"Undisclosed","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase II","graph3":"Protalix BioTherapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Respiratory Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Protalix BioTherapeutics \/ Protalix BioTherapeutics","highestDevelopmentStatusID":"8","companyTruncated":"Protalix BioTherapeutics \/ Protalix BioTherapeutics"}]

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                            01

                            Protalix BioTherapeutics

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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Recipient : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Chiesi & Protalix Announce EMA Validation for Pegunigalsidase Alfa Submission

                            Details : Elfabrio (pegunigalsidase alfa) is a globotriaosylceramide inhibitor enzyme drug candidate, which is being evaluated to label a less frequent dosing regimen for treating fabry disease.

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            December 09, 2024

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Recipient : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Protalix BioTherapeutics

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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Chiesi Global Rare Diseases and Protalix BioTherapeutics Announce FDA Approval of ELFABRIO® (pegunigalsidase ...

                            Details : Elfabrio (pegunigalsidase alfa-iwxj) is a PEGylated enzyme replacement therapy (ERT) for the treatment of adult patients with Fabry disease. It is a recombinant human α–Galactosidase–A enzyme expressed in plant-cell culture that is designed to provi...

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            October 05, 2023

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Protalix BioTherapeutics

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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Chiesi Global Rare Diseases and Protalix BioTherapeutics Announce European Commission Authorization of PRX-102...

                            Details : PRX-102 (pegunigalsidase alfa), EC authorized, is a novel PEGylated, covalently crosslinked form of α-galactosidase-A developed as enzyme replacement therapy for fabry disease, was designed to increase plasma half-life and reduce immunogenicity, thereby...

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            May 05, 2023

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Protalix BioTherapeutics

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                            Lead Product(s) : PRX-115

                            Therapeutic Area : Rheumatology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Protalix BioTherapeutics Announces First Patient Dosed in First in Human Phase I Clinical Trial of PRX-115 for...

                            Details : PRX-115 is a PEGylated enzyme expressed via ProCellEx® for intravenous (IV) administration of recombinant Uricase, designed for safe and efficacious treatment of refractory gout

                            Product Name : Undisclosed

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            March 21, 2023

                            Lead Product(s) : PRX-115

                            Therapeutic Area : Rheumatology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Protalix BioTherapeutics

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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Recipient : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Chiesi Global Rare Diseases and Protalix BioTherapeutics Receive Positive CHMP Opinion for Pegunigalsidase Alf...

                            Details : PRX–102 (pegunigalsidase alfa) a novel PEGylated, covalently crosslinked form of α-galactosidase A developed as enzyme replacement therapy for fabry disease, was designed to increase plasma half-life and reduce immunogenicity, thereby enhancing effica...

                            Product Name : Undisclosed

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            February 24, 2023

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Recipient : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Protalix BioTherapeutics

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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Protalix BioTherapeutics and Chiesi Global Rare Diseases Announce Resubmission of Biologics License Applicatio...

                            Details : PRX–102 (pegunigalsidase alfa) is an investigational, plant cell culture-expressed, and chemically modified stabilized version of the recombinant α–Galactosidase–A enzyme.

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            November 14, 2022

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Protalix BioTherapeutics

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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Protalix BioTherapeutics and Chiesi Global Rare Diseases Announce U.S. Food and Drug Administration Acceptance...

                            Details : PRX–102 (pegunigalsidase alfa) is an investigational, plant cell culture-expressed, and chemically modified stabilized version of the recombinant α–Galactosidase–A enzyme. It is a novel, PEGylated ERT under development for the treatment of Fabry d...

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            May 12, 2022

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Protalix BioTherapeutics

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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Recipient : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Chiesi Global Rare Diseases Announces Presentations on Lysosomal Storage Diseases at the Society for the Study...

                            Details : Results from the clinical development programme developed with Protalix BioTherapeutics evaluating pegunigalsidase alfa (PRX-102) an investigational enzyme replacement therapy (ERT), support its potential as a treatment option for adult patients with Fab...

                            Product Name : Undisclosed

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            February 09, 2022

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Recipient : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Protalix BioTherapeutics

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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Protalix Biotherapeutics and Chiesi Global Rare Diseases Provide Regulatory Update on PRX-102 for the Treatmen...

                            Details : Pegunigalsidase alfa (PRX–102) is an investigational, plant cell culture-expressed, and chemically modified stabilized version of the recombinant α–Galactosidase–A enzyme. Protein sub-units are covalently bound via chemical cross-linking using sho...

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            November 10, 2021

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Chiesi Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Protalix BioTherapeutics and Chiesi Global Rare Diseases Present Key Clinical Data of Pegunigalsidase Alfa for...

                            Details : Following the switch to pegunigalsidase alfa there was a decrease in patients with progressing or fast progressing kidney disease, and the majority of patients achieved a stable status post-switch.

                            Product Name : Elfabrio

                            Product Type : Enzyme

                            Upfront Cash : Inapplicable

                            October 02, 2021

                            Lead Product(s) : Pegunigalsidase Alpha

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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