
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : Undisclosed
Therapeutic Area : Nephrology
Study Phase : Discovery Platform
Sponsor : Secarna Pharma
Deal Size : Undisclosed
Deal Type : Collaboration
Protalix Biotherapeutics, Secarna Pharmaceuticals Collaborate and Option Agreement
Details : The collaboration aims to advance the development of an undisclosed oligonucleotide for renal diseases.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Undisclosed
December 17, 2025
Lead Product(s) : Undisclosed
Therapeutic Area : Nephrology
Highest Development Status : Discovery Platform
Sponsor : Secarna Pharma
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : PRX-115,Methotrexate
Therapeutic Area : Rheumatology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PRX-115 is a Enzyme drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Gout.
Product Name : Undisclosed
Product Type : Enzyme
Upfront Cash : Inapplicable
December 12, 2025
Lead Product(s) : PRX-115,Methotrexate
Therapeutic Area : Rheumatology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Pegunigalsidase Alpha
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Recipient : Chiesi Group
Deal Size : Inapplicable
Deal Type : Inapplicable
Chiesi & Protalix Announce EMA Validation for Pegunigalsidase Alfa Submission
Details : Elfabrio (pegunigalsidase alfa) is a globotriaosylceramide inhibitor enzyme drug candidate, which is being evaluated to label a less frequent dosing regimen for treating fabry disease.
Product Name : Elfabrio
Product Type : Enzyme
Upfront Cash : Inapplicable
December 09, 2024
Lead Product(s) : Pegunigalsidase Alpha
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Recipient : Chiesi Group
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Pegunigalsidase Alpha
Therapeutic Area : Genetic Disease
Study Phase : Approved FDF
Sponsor : Chiesi Group
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Elfabrio (pegunigalsidase alfa-iwxj) is a PEGylated enzyme replacement therapy (ERT) for the treatment of adult patients with Fabry disease. It is a recombinant human α–Galactosidase–A enzyme expressed in plant-cell culture that is designed to provi...
Product Name : Elfabrio
Product Type : Enzyme
Upfront Cash : Inapplicable
May 10, 2023
Lead Product(s) : Pegunigalsidase Alpha
Therapeutic Area : Genetic Disease
Highest Development Status : Approved FDF
Sponsor : Chiesi Group
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Pegunigalsidase Alpha
Therapeutic Area : Genetic Disease
Study Phase : Approved FDF
Sponsor : Chiesi Group
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PRX-102 (pegunigalsidase alfa), EC authorized, is a novel PEGylated, covalently crosslinked form of α-galactosidase-A developed as enzyme replacement therapy for fabry disease, was designed to increase plasma half-life and reduce immunogenicity, thereby...
Product Name : Elfabrio
Product Type : Enzyme
Upfront Cash : Inapplicable
May 05, 2023
Lead Product(s) : Pegunigalsidase Alpha
Therapeutic Area : Genetic Disease
Highest Development Status : Approved FDF
Sponsor : Chiesi Group
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : PRX-115
Therapeutic Area : Rheumatology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PRX-115 is a PEGylated enzyme expressed via ProCellEx® for intravenous (IV) administration of recombinant Uricase, designed for safe and efficacious treatment of refractory gout
Product Name : Undisclosed
Product Type : Enzyme
Upfront Cash : Inapplicable
March 21, 2023
Lead Product(s) : PRX-115
Therapeutic Area : Rheumatology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Pegunigalsidase Alpha
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Recipient : Chiesi Group
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PRX–102 (pegunigalsidase alfa) a novel PEGylated, covalently crosslinked form of α-galactosidase A developed as enzyme replacement therapy for fabry disease, was designed to increase plasma half-life and reduce immunogenicity, thereby enhancing effica...
Product Name : Undisclosed
Product Type : Enzyme
Upfront Cash : Inapplicable
February 24, 2023
Lead Product(s) : Pegunigalsidase Alpha
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Recipient : Chiesi Group
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Pegunigalsidase Alpha
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Sponsor : Chiesi Group
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PRX–102 (pegunigalsidase alfa) is an investigational, plant cell culture-expressed, and chemically modified stabilized version of the recombinant α–Galactosidase–A enzyme. It is a novel, PEGylated ERT under development for the treatment of Fabry d...
Product Name : Elfabrio
Product Type : Enzyme
Upfront Cash : Inapplicable
December 05, 2022
Lead Product(s) : Pegunigalsidase Alpha
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Sponsor : Chiesi Group
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Pegunigalsidase Alpha
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Sponsor : Chiesi Group
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PRX–102 (pegunigalsidase alfa) is an investigational, plant cell culture-expressed, and chemically modified stabilized version of the recombinant α–Galactosidase–A enzyme.
Product Name : Elfabrio
Product Type : Enzyme
Upfront Cash : Inapplicable
November 14, 2022
Lead Product(s) : Pegunigalsidase Alpha
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Sponsor : Chiesi Group
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Pegunigalsidase Alpha
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Recipient : Chiesi Group
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Results from the clinical development programme developed with Protalix BioTherapeutics evaluating pegunigalsidase alfa (PRX-102) an investigational enzyme replacement therapy (ERT), support its potential as a treatment option for adult patients with Fab...
Product Name : Undisclosed
Product Type : Enzyme
Upfront Cash : Inapplicable
September 02, 2022
Lead Product(s) : Pegunigalsidase Alpha
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Recipient : Chiesi Group
Deal Size : Inapplicable
Deal Type : Inapplicable
