
 
													 
									 
															 
															Year
 
															DEALS // DEV.
 
															Country
 
															 
															Therapeutic Area
 
															Study Phase
 
															Deal Type
 
															Product Type
 
															Dosage Form
 
															Lead Product
 
															Target

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Lead Product(s) : Tulisokibart
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Merck & Co
Deal Size : $10,800.0 million
Deal Type : Acquisition
Merck Completes Acquisition of Prometheus Biosciences, Inc.
Details : The acquisition will strengthen Merck's immunology pipeline by adding diversity of portfolio including, MK-7240 (tulisokibart), a humanized monoclonal antibody directed to tumor necrosis factor-like ligand 1A, a target associated with both intestinal inf...
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : $10,800.0 million
June 16, 2023
Lead Product(s) : Tulisokibart
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Merck & Co
Deal Size : $10,800.0 million
Deal Type : Acquisition

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Lead Product(s) : PRA023
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Merck & Co
Deal Size : $10,800.0 million
Deal Type : Acquisition
Merck Strengthens Immunology Pipeline with Acquisition of Prometheus Biosciences, Inc.
Details : The acquisition will strengthen Merck's immunology pipeline by adding diversity of portfolio including, PRA023 (tulisokibart), a humanized monoclonal antibody directed to tumor necrosis factor-like ligand 1A, a target associated with both intestinal infl...
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : $10,800.0 million
April 16, 2023
Lead Product(s) : PRA023
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Merck & Co
Deal Size : $10,800.0 million
Deal Type : Acquisition

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Lead Product(s) : PRA023
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PRA023 is a humanized IgG1 mAb that has been shown to block the tumor necrosis factor (TNF)-like ligand 1A (TL1A), a target associated with both intestinal inflammation and fibrosis. It is currently in phase 2a clinical trial for crohn's disease.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
February 22, 2023
Lead Product(s) : PRA023
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : PRA023
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Goldman Sachs & Co
Deal Size : $500.0 million
Deal Type : Public Offering
Details : Prometheus intends to use the net proceeds from this offering, together with its existing cash, cash equivalents and short-term investments to fund the development of PRA023 (a monoclonal antibody against cytokine TL1A), PRA052 and its other research and...
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Undisclosed
December 08, 2022
Lead Product(s) : PRA023
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Goldman Sachs & Co
Deal Size : $500.0 million
Deal Type : Public Offering

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Lead Product(s) : PRA023
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Goldman Sachs & Co
Deal Size : $250.0 million
Deal Type : Public Offering
Prometheus Biosciences, Inc. Announces Proposed Public Offering of Common Stock
Details : Prometheus intends to use the net proceeds from this offering, together with its existing cash, cash equivalents and short-term investments to fund the development of PRA023, PRA052 and its other research and development programs.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Undisclosed
December 07, 2022
Lead Product(s) : PRA023
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Goldman Sachs & Co
Deal Size : $250.0 million
Deal Type : Public Offering

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Lead Product(s) : PRA023
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PRA023 binds both soluble and membrane-associated human TL1A with high affinity and specificity and has the potential to substantially improve outcomes for moderate-to-severe IBD patients predisposed to increased TL1A expression.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
December 07, 2022
Lead Product(s) : PRA023
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : PRA052
Therapeutic Area : Immunology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PRA052 is a monoclonal antibody blocking CD30 ligand that has a pleiotropic effect on both innate and adaptive immunity and targets a pathway that is distinct from TNF.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
October 03, 2022
Lead Product(s) : PRA052
Therapeutic Area : Immunology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : PRA023
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PRA023, is a monoclonal antibody against cytokine TL1A, a target associated with both intestinal inflammation and fibrosis,for the treatment of Ulcerative Colitis.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
July 18, 2022
Lead Product(s) : PRA023
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : PRA023
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Prometheus Biosciences Provides Enrollment Update in APOLLO-CD and ARTEMIS-UC Global Phase 2 Studies
Details : PRA023 is an IgG1 humanized mAB block TNF-like ligand 1A, binds both soluble and membrane-associated human TL1A with high affinity and specificity and has potential to substantially improve outcomes for IBD patients predisposed to increased TL1A expressi...
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
June 08, 2022
Lead Product(s) : PRA023
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : PRA023
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PRA023 is an IgG1 humanized monoclonal antibody (mAb) that has been shown to block tumor necrosis factor like ligand 1A (TL1A), binds both soluble and membrane-associated human TL1A with high affinity and specificity and has the potential to improve outc...
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
March 30, 2022
Lead Product(s) : PRA023
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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