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    [{"orgOrder":0,"company":"ProfoundBio","sponsor":"Genmab","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CHINA","productType":"Antibody-drug Conjugate","year":"2024","type":"Acquisition","leadProduct":"Rinatabart Sesutecan","moa":"Folate-alpha receptor","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ProfoundBio","amount2":1.8,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":1.8,"dosageForm":"Infusion","sponsorNew":"ProfoundBio \/ Genmab","highestDevelopmentStatusID":"7","companyTruncated":"ProfoundBio \/ Genmab"},{"orgOrder":0,"company":"ProfoundBio","sponsor":"Genmab","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CHINA","productType":"Antibody-drug Conjugate","year":"2024","type":"Acquisition","leadProduct":"Rinatabart Sesutecan","moa":"Folate-alpha receptor","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ProfoundBio","amount2":1.8,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":1.8,"dosageForm":"Infusion","sponsorNew":"ProfoundBio \/ Genmab","highestDevelopmentStatusID":"7","companyTruncated":"ProfoundBio \/ Genmab"},{"orgOrder":0,"company":"ProfoundBio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Antibody-drug Conjugate","year":"2024","type":"Inapplicable","leadProduct":"Rinatabart Sesutecan","moa":"Folate-alpha receptor","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ProfoundBio","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"ProfoundBio \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"ProfoundBio \/ Undisclosed"},{"orgOrder":0,"company":"ProfoundBio","sponsor":"Ally Bridge Group","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CHINA","productType":"Antibody-drug Conjugate","year":"2024","type":"Series B Financing","leadProduct":"Rinatabart Sesutecan","moa":"Folate-alpha receptor","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ProfoundBio","amount2":0.11,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.11,"dosageForm":"Infusion","sponsorNew":"ProfoundBio \/ Ally Bridge Group","highestDevelopmentStatusID":"7","companyTruncated":"ProfoundBio \/ Ally Bridge Group"},{"orgOrder":0,"company":"ProfoundBio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Antibody-drug Conjugate","year":"2023","type":"Inapplicable","leadProduct":"PRO1184","moa":"FOLR1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ProfoundBio","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"ProfoundBio \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"ProfoundBio \/ Undisclosed"},{"orgOrder":0,"company":"ProfoundBio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Antibody-drug Conjugate","year":"2022","type":"Inapplicable","leadProduct":"PRO1184","moa":"FOLR1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ProfoundBio","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"ProfoundBio \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"ProfoundBio \/ Undisclosed"},{"orgOrder":0,"company":"ProfoundBio","sponsor":"Sequoia China","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CHINA","productType":"Antibody-drug Conjugate","year":"2022","type":"Series A Financing","leadProduct":"PRO1184","moa":"FOLR1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ProfoundBio","amount2":0.070000000000000007,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.070000000000000007,"dosageForm":"Infusion","sponsorNew":"ProfoundBio \/ Sequoia China","highestDevelopmentStatusID":"7","companyTruncated":"ProfoundBio \/ Sequoia China"},{"orgOrder":0,"company":"ProfoundBio","sponsor":"Synaffix","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CHINA","productType":"Antibody-drug Conjugate","year":"2021","type":"Licensing Agreement","leadProduct":"PRO1184","moa":"FOLR1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ProfoundBio","amount2":0.25,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.25,"dosageForm":"Infusion","sponsorNew":"ProfoundBio \/ Synaffix","highestDevelopmentStatusID":"7","companyTruncated":"ProfoundBio \/ Synaffix"},{"orgOrder":0,"company":"ProfoundBio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"PRO1107","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ProfoundBio","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"ProfoundBio \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"ProfoundBio \/ Undisclosed"},{"orgOrder":0,"company":"ProfoundBio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Undisclosed","year":"2023","type":"Inapplicable","leadProduct":"PRO1160","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ProfoundBio","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"ProfoundBio \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"ProfoundBio \/ Undisclosed"}]

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                            01

                            ProfoundBio

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                            Lead Product(s) : Rinatabart Sesutecan

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Rinatabart Sesutecan Shows Promising Anti-Tumor Activity in Ovarian and Endometrial Cancer

                            Details : Rina-S (rinatabart sesutecan) is an investigational FRα-targeted, Topo1 ADC, which is being evaluated for FR alpha-expressing ovarian cancer, endometrial cancer, primary peritoneal carcinoma.

                            Product Name : Rina-S

                            Product Type : Antibody-drug Conjugate

                            Upfront Cash : Inapplicable

                            September 15, 2024

                            Lead Product(s) : Rinatabart Sesutecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            ProfoundBio

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                            ProfoundBio

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                            Lead Product(s) : Rinatabart Sesutecan

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Genmab

                            Deal Size : $1,800.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Genmab Completes Acquisition of ProfoundBio

                            Details : The acquisition grants Genmab worldwide rights to three clinical candidates, including Rina-S (rinatabart sesutecan), an FRα-targeted ADC aimed at treating ovarian and endometrial cancer.

                            Product Name : Rina-S

                            Product Type : Antibody-drug Conjugate

                            Upfront Cash : $1,800.0 million

                            May 21, 2024

                            Lead Product(s) : Rinatabart Sesutecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Genmab

                            Deal Size : $1,800.0 million

                            Deal Type : Acquisition

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                            03

                            ProfoundBio

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                            Lead Product(s) : Rinatabart Sesutecan

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Genmab

                            Deal Size : $1,800.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Genmab to Broaden and Strengthen Oncology Portfolio with Acquisition of ProfoundBio

                            Details : Genmab acquires worldwide rights to PRO1184 (rinatabart sesutecan) for treating FRα-expressing platinum-resistant ovarian cancer and two other clinical candidates.

                            Product Name : Rina-S

                            Product Type : Antibody-drug Conjugate

                            Upfront Cash : $1,800.0 million

                            April 03, 2024

                            Lead Product(s) : Rinatabart Sesutecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Genmab

                            Deal Size : $1,800.0 million

                            Deal Type : Acquisition

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                            04

                            ProfoundBio

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                            ProfoundBio

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                            Lead Product(s) : Rinatabart Sesutecan

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Ally Bridge Group

                            Deal Size : $112.0 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            ProfoundBio Raises $112M in Series B Financing to Advance ADC Pipeline

                            Details : The financing aims to support the development of ProfoundBio's PRO1184 (rinatabart sesutecan), which is a FRα-targeted ADC being developed for patients with ovarian and endometrial cancer.

                            Product Name : Rina-S

                            Product Type : Antibody-drug Conjugate

                            Upfront Cash : Undisclosed

                            February 13, 2024

                            Lead Product(s) : Rinatabart Sesutecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Ally Bridge Group

                            Deal Size : $112.0 million

                            Deal Type : Series B Financing

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                            05

                            ProfoundBio

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                            ProfoundBio

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                            Lead Product(s) : PRO1107

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ProfoundBio Doses First Patient in Phase 1/2 Trial of PRO1107, a PTK7-Targeted ADC

                            Details : PRO1107 is an ADC targeting PTK7, currently in trials for PTK7-expressing endometrial, ovarian, and triple-negative breast cancers.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            February 05, 2024

                            Lead Product(s) : PRO1107

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            ProfoundBio

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                            Lead Product(s) : PRO1160

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Trial of PRO1160 (GEN1160) in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) (PRO1160-001)

                            Details : PRO1160 is a drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Carcinoma, Renal Cell.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            February 09, 2023

                            Lead Product(s) : PRO1160

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            ProfoundBio

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                            ProfoundBio

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                            Lead Product(s) : PRO1184

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ProfoundBio Announces Initiation of First-in-Human Trial for PRO1184, a Folate Receptor Alpha-Directed ADC wit...

                            Details : PRO1184 demonstrates robust anti-tumor activity, is an ADC comprising a folate receptor alpha-directed antibody conjugated to the exatecan payload with ProfoundBio's novel, proprietary hydrophilic linker.

                            Product Name : Undisclosed

                            Product Type : Antibody-drug Conjugate

                            Upfront Cash : Inapplicable

                            January 03, 2023

                            Lead Product(s) : PRO1184

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            ProfoundBio

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                            ProfoundBio

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                            Lead Product(s) : PRO1184

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ProfoundBio Receives FDA "Study May Proceed" Letter for PRO1184, a Folate Receptor Alpha-Directed ADC with a T...

                            Details : PRO1184 is an antibody-drug conjugate comprising a folate receptor alpha (FRa) directed antibody conjugated to an exatecan payload with a novel, proprietary hydrophilic linker.

                            Product Name : Undisclosed

                            Product Type : Antibody-drug Conjugate

                            Upfront Cash : Inapplicable

                            August 03, 2022

                            Lead Product(s) : PRO1184

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            ProfoundBio

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                            ProfoundBio

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                            Lead Product(s) : PRO1184

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Sequoia China

                            Deal Size : $70.0 million

                            Deal Type : Series A Financing

                            DEALS_DEV arrow-down

                            ProfoundBio Announces Completion of $70 Million Series A+ Financing to Advance Antibody-Drug Conjugate (ADC) P...

                            Details : ProfoundBio will use the proceeds to advance PRO1184 and PRO1160 into Phase 1 clinical trials. PRO1184 is a folate receptor alpha directed ADC for potential treatment of multiple solid tumors and PRO1160 is CD70-directed ADC for both hematological and so...

                            Product Name : Undisclosed

                            Product Type : Antibody-drug Conjugate

                            Upfront Cash : Undisclosed

                            June 02, 2022

                            Lead Product(s) : PRO1184

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Sequoia China

                            Deal Size : $70.0 million

                            Deal Type : Series A Financing

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                            10

                            ProfoundBio

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                            ProfoundBio

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                            Lead Product(s) : PRO1184

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Synaffix

                            Deal Size : $246.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Synaffix Announces Deal with ProfoundBio Worth up to $246 Million Providing Access to Multiple Novel Linker-Pa...

                            Details : The deal provides access to multiple novel linker-payload technologies developed by Synaffix and includes access to the GlycoConnect™ glycan conjugation and HydraSpace™ polar spacer technologies.

                            Product Name : Undisclosed

                            Product Type : Antibody-drug Conjugate

                            Upfront Cash : Undisclosed

                            July 22, 2021

                            Lead Product(s) : PRO1184

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Synaffix

                            Deal Size : $246.0 million

                            Deal Type : Licensing Agreement

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