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    [{"orgOrder":0,"company":"St. Jude Children","sponsor":"Eli Lilly","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2019","type":"Inapplicable","leadProduct":"Prexasertib","moa":"Serine\/threonine-protein kinase Chk2 | Serine\/threonine-protein kinase Chk1","graph1":"Oncology","graph2":"Phase I","graph3":"St. Jude Children","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"St. Jude Children \/ Eli Lilly","highestDevelopmentStatusID":"6","companyTruncated":"St. Jude Children \/ Eli Lilly"},{"orgOrder":0,"company":"Children's Oncology Group","sponsor":"National Cancer Institute","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2016","type":"Inapplicable","leadProduct":"Prexasertib","moa":"Serine\/threonine-protein kinase Chk2 | Serine\/threonine-protein kinase 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    Find Clinical Drug Pipeline Developments & Deals for Prexasertib

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                            01

                            Acrivon Therapeutics

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                            OTS 2025
                            Not Confirmed

                            Acrivon Therapeutics

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                            Lead Product(s) : Prexasertib,Gemcitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Acrivon Stops Testing Lilly Castoff for Ovarian, Bladder Cancer

                            Details : ACR-368 (prexasertib), a potent, selective CHK1/2 inhibitor, is deprioritized for ovarian and bladder cancers as targets and will be redirected to testing in endometrial cancer.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            March 26, 2025

                            Lead Product(s) : Prexasertib,Gemcitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Acrivon Therapeutics

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                            OTS 2025
                            Not Confirmed

                            Acrivon Therapeutics

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                            OTS 2025
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                            Lead Product(s) : Prexasertib,Gemcitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : RA Capital Management

                            Deal Size : $130.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Acrivon Therapeutics Announces $130 Million Private Placement Financing

                            Details : The proceeds will advance ACR-368 (prexasertib), a selective small molecule inhibitor targeting CHK1 and CHK2 in Phase 2 trials, and its preclinical pipeline, including ACR-2316.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            April 09, 2024

                            Lead Product(s) : Prexasertib,Gemcitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : RA Capital Management

                            Deal Size : $130.0 million

                            Deal Type : Private Placement

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                            03

                            Acrivon Therapeutics

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                            OTS 2025
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                            Acrivon Therapeutics

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                            OTS 2025
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                            Lead Product(s) : Prexasertib,Gemcitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Jefferies

                            Deal Size : $99.4 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Acrivon Therapeutics Announces Pricing of Initial Public Offering

                            Details : Acrivon is currently advancing its lead candidate, ACR-368 (prexasertib), a selective small molecule inhibitor targeting CHK1 and CHK2 in a potentially registrational Phase 2 trial across multiple tumor types.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            November 15, 2022

                            Lead Product(s) : Prexasertib,Gemcitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Jefferies

                            Deal Size : $99.4 million

                            Deal Type : Public Offering

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                            04

                            Acrivon Therapeutics

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed

                            Acrivon Therapeutics

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                            OTS 2025
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                            Lead Product(s) : Prexasertib,Gemcitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Wellington Management Company

                            Deal Size : $100.0 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            Acrivon Therapeutics Closes Oversubscribed $100 Million Series B Financing to Advance its Innovative Precision...

                            Details : Proceeds will support the clinical development of advanced Phase 2 lead asset ACR-368, a potent DNA Damage Response (DDR) inhibitor clinically validated in solid cancers, and in-house drug pipeline driven by the company’s proprietary platform technolog...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            November 11, 2021

                            Lead Product(s) : Prexasertib,Gemcitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Wellington Management Company

                            Deal Size : $100.0 million

                            Deal Type : Series B Financing

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                            05

                            Acrivon Therapeutics

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                            OTS 2025
                            Not Confirmed

                            Acrivon Therapeutics

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                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Prexasertib,Gemcitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Acrivon Therapeutics Launches to Advance Clinical Oncology Pipeline Leveraging its Groundbreaking Precision Pr...

                            Details : Acrivon intends to develop prexasertib (also called ACR-368) in accelerated clinical trials treating patients whose tumors are driven by, and depend on, dysregulated CHK1 and CHK2 using the OncoSignature® test.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            June 29, 2021

                            Lead Product(s) : Prexasertib,Gemcitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            St. Jude Children

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                            OTS 2025
                            Not Confirmed

                            St. Jude Children

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                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Prexasertib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Eli Lilly

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescen...

                            Details : Prexasertib is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Brain Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            July 17, 2019

                            Lead Product(s) : Prexasertib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Eli Lilly

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Dana-Farber Cancer Institute

                            U.S.A arrow
                            OTS 2025
                            Not Confirmed

                            Dana-Farber Cancer Institute

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                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Prexasertib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Eli Lilly

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Prexasertib in Combination With MEC in Relapsed/Refractory AML and High Risk MDS - a Phase I Trial

                            Details : Prexasertib is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Leukemia, Myeloid, Acute.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            November 08, 2018

                            Lead Product(s) : Prexasertib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Eli Lilly

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Eli Lilly

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                            OTS 2025
                            Not Confirmed

                            Eli Lilly

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                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Prexasertib

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of Prexasertib (LY2606368) in Platinum-Resistant or Refractory Recurrent Ovarian Cancer

                            Details : Prexasertib is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Ovarian Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            January 29, 2018

                            Lead Product(s) : Prexasertib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Geoffrey Shapiro

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                            OTS 2025
                            Not Confirmed

                            Geoffrey Shapiro

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                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Prexasertib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Eli Lilly | AstraZeneca

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Combination Study of Prexasertib and Olaparib in Patients With Advanced Solid Tumors

                            Details : Prexasertib is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            February 17, 2017

                            Lead Product(s) : Prexasertib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Eli Lilly | AstraZeneca

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Eli Lilly

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                            OTS 2025
                            Not Confirmed

                            Eli Lilly

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                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Prexasertib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of Prexasertib (LY2606368) in Combination With Ralimetinib in Participants With Advanced or Metastatic...

                            Details : Prexasertib is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            August 09, 2016

                            Lead Product(s) : Prexasertib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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