[{"orgOrder":0,"company":"Pregene","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cell & Gene Therapy","year":"2022","type":"Inapplicable","leadProduct":"BCMA CAR-NK Cell","moa":"B-cell maturation antigen","graph1":"Oncology","graph2":"Phase I","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Pregene \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Pregene \/ Undisclosed"},{"orgOrder":0,"company":"Pregene","sponsor":"Pregene","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cell & Gene Therapy","year":"2018","type":"Inapplicable","leadProduct":"BCMA Nanobody CAR-T Cell","moa":"B-cell maturation antigen","graph1":"Oncology","graph2":"Phase I","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Pregene \/ Pregene","highestDevelopmentStatusID":"6","companyTruncated":"Pregene \/ Pregene"},{"orgOrder":0,"company":"Pregene","sponsor":"Dr. Reddy's Laboratories","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CHINA","productType":"Undisclosed","year":"2021","type":"Licensing Agreement","leadProduct":"PRG1801","moa":"B-cell maturation antigen","graph1":"Oncology","graph2":"Phase I","graph3":"Pregene","amount2":0.16,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0.16,"dosageForm":"Infusion","sponsorNew":"Pregene \/ Dr. Reddy's Laboratories","highestDevelopmentStatusID":"6","companyTruncated":"Pregene \/ Dr. Reddy's Laboratories"},{"orgOrder":0,"company":"Pregene","sponsor":"Henan Cancer Hospital","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cell & Gene Therapy","year":"2018","type":"Inapplicable","leadProduct":"BCMA CAR-T Cell","moa":"B-cell maturation antigen","graph1":"Oncology","graph2":"Phase I","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pregene \/ Henan Cancer Hospital","highestDevelopmentStatusID":"6","companyTruncated":"Pregene \/ Henan Cancer Hospital"},{"orgOrder":0,"company":"Pregene","sponsor":"Pregene","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cell & Gene Therapy","year":"2024","type":"Inapplicable","leadProduct":"ESO-T01","moa":"BCMA receptor","graph1":"Oncology","graph2":"Phase I","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Pregene \/ Pregene","highestDevelopmentStatusID":"6","companyTruncated":"Pregene \/ Pregene"},{"orgOrder":0,"company":"Pregene","sponsor":"Pregene","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cell & Gene Therapy","year":"2018","type":"Inapplicable","leadProduct":"CAR19-T Cell","moa":"CD19","graph1":"Oncology","graph2":"Phase I","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Pregene \/ Pregene","highestDevelopmentStatusID":"6","companyTruncated":"Pregene \/ Pregene"},{"orgOrder":0,"company":"Pregene","sponsor":"Pregene","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cytotoxic Drug","year":"2017","type":"Inapplicable","leadProduct":"Cyclophosphamide","moa":"DNA","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pregene \/ Pregene","highestDevelopmentStatusID":"7","companyTruncated":"Pregene \/ Pregene"},{"orgOrder":0,"company":"Pregene","sponsor":"Pregene","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cytotoxic Drug","year":"2016","type":"Inapplicable","leadProduct":"Cyclophosphamide","moa":"DNA","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pregene \/ Pregene","highestDevelopmentStatusID":"7","companyTruncated":"Pregene \/ Pregene"},{"orgOrder":0,"company":"Pregene","sponsor":"Pregene","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cytotoxic Drug","year":"2017","type":"Inapplicable","leadProduct":"Cyclophosphamide","moa":"DNA","graph1":"Oncology","graph2":"Phase I","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pregene \/ Pregene","highestDevelopmentStatusID":"6","companyTruncated":"Pregene \/ Pregene"},{"orgOrder":0,"company":"Pregene","sponsor":"Pregene","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Miscellaneous","year":"2017","type":"Inapplicable","leadProduct":"Fludarabine Phosphate","moa":"DNA polymerase (alpha\/delta\/epsilon) | Ribonucleoside-diphosphate reductase RR1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pregene \/ Pregene","highestDevelopmentStatusID":"7","companyTruncated":"Pregene \/ Pregene"},{"orgOrder":0,"company":"Pregene","sponsor":"Pregene","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Miscellaneous","year":"2017","type":"Inapplicable","leadProduct":"Fludarabine Phosphate","moa":"DNA polymerase (alpha\/delta\/epsilon) | Ribonucleoside-diphosphate reductase RR1","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pregene \/ Pregene","highestDevelopmentStatusID":"7","companyTruncated":"Pregene \/ Pregene"},{"orgOrder":0,"company":"Pregene","sponsor":"Pregene","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Undisclosed","year":"2018","type":"Inapplicable","leadProduct":"EGFR IL12 CART","moa":"EGFR \/ IL-12","graph1":"Oncology","graph2":"Phase I","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pregene \/ Pregene","highestDevelopmentStatusID":"6","companyTruncated":"Pregene \/ Pregene"},{"orgOrder":0,"company":"Pregene","sponsor":"Pregene","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cell & Gene Therapy","year":"2017","type":"Inapplicable","leadProduct":"EGFR CART","moa":"Epidermal growth factor receptor (EGFR)","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pregene \/ Pregene","highestDevelopmentStatusID":"7","companyTruncated":"Pregene \/ Pregene"},{"orgOrder":0,"company":"Pregene","sponsor":"Bone Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Orthopedics\/Orthopedic Surgery","country":"BELGIUM","productType":"Cell & Gene Therapy","year":"2022","type":"Termination","leadProduct":"Allogeneic Bone-Forming Cell","moa":"Undisclosed","graph1":"Orthopedics\/Orthopedic Surgery","graph2":"Phase II","graph3":"Pregene","amount2":0.050000000000000003,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Orthopedics","amount2New":0.050000000000000003,"dosageForm":"Injection","sponsorNew":"Pregene \/ Pregene","highestDevelopmentStatusID":"8","companyTruncated":"Pregene \/ Pregene"},{"orgOrder":0,"company":"Pregene","sponsor":"Pregene","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"CHINA","productType":"Undisclosed","year":"2024","type":"Inapplicable","leadProduct":"PRG-1801","moa":"Undisclosed","graph1":"Immunology","graph2":"Phase I","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Pregene \/ Pregene","highestDevelopmentStatusID":"6","companyTruncated":"Pregene \/ Pregene"},{"orgOrder":0,"company":"Pregene","sponsor":"Pregene","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"CHINA","productType":"Undisclosed","year":"2024","type":"Inapplicable","leadProduct":"PRG-1801","moa":"Undisclosed","graph1":"Nephrology","graph2":"Phase I","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pregene \/ Pregene","highestDevelopmentStatusID":"6","companyTruncated":"Pregene \/ Pregene"},{"orgOrder":0,"company":"Pregene","sponsor":"Pregene","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"CHINA","productType":"Undisclosed","year":"2024","type":"Inapplicable","leadProduct":"PRG-2311","moa":"Undisclosed","graph1":"Nephrology","graph2":"Phase I","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pregene \/ Pregene","highestDevelopmentStatusID":"6","companyTruncated":"Pregene \/ Pregene"},{"orgOrder":0,"company":"Pregene","sponsor":"Chunrui Li","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Cell & Gene Therapy","year":"2025","type":"Inapplicable","leadProduct":"ESO-T01","moa":"BCMA receptor","graph1":"Oncology","graph2":"Phase I","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Pregene \/ Chunrui Li","highestDevelopmentStatusID":"6","companyTruncated":"Pregene \/ Chunrui Li"},{"orgOrder":0,"company":"Pregene","sponsor":"Lingli Dong","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"CHINA","productType":"Undisclosed","year":"2024","type":"Inapplicable","leadProduct":"PRG-1801","moa":"Undisclosed","graph1":"Nephrology","graph2":"Undisclosed","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pregene \/ Lingli Dong","highestDevelopmentStatusID":"1","companyTruncated":"Pregene \/ Lingli Dong"},{"orgOrder":0,"company":"Pregene","sponsor":"Tan Jie","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Undisclosed","year":"2024","type":"Inapplicable","leadProduct":"PRG2302","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I","graph3":"Pregene","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pregene \/ Tan Jie","highestDevelopmentStatusID":"6","companyTruncated":"Pregene \/ Tan Jie"},{"orgOrder":0,"company":"Pregene","sponsor":"Kite Pharma","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2025","type":"Acquisition","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase II","graph3":"Pregene","amount2":1.6399999999999999,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":1.6399999999999999,"dosageForm":"Undisclosed","sponsorNew":"Pregene \/ Kite Pharma","highestDevelopmentStatusID":"8","companyTruncated":"Pregene \/ Kite Pharma"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          CTAD25
                          Not Confirmed
                          CTAD25
                          Not Confirmed

                          Details : Under the acquisition, an undisclosed cell & gene therapy product for hematological malignancies has been acquired to advance treatment options.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : $120.0 million

                          October 17, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Kite Pharma

                          Deal Size : $1,640.0 million

                          Deal Type : Acquisition

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                          02

                          CTAD25
                          Not Confirmed
                          CTAD25
                          Not Confirmed

                          Details : ESO-T01 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Multiple Myeloma.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          January 24, 2025

                          Lead Product(s) : ESO-T01

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Chunrui Li

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          CTAD25
                          Not Confirmed
                          CTAD25
                          Not Confirmed

                          Details : ESO-T01 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Multiple Myeloma.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          November 15, 2024

                          Lead Product(s) : ESO-T01

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Recipient : Wuhan Union Hospital

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          CTAD25
                          Not Confirmed
                          CTAD25
                          Not Confirmed

                          Details : PRG2302 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Precursor Cell Lymphoblastic Leukemia-Lymphoma.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          October 26, 2024

                          Lead Product(s) : PRG2302

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Tan Jie

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          CTAD25
                          Not Confirmed
                          CTAD25
                          Not Confirmed

                          Details : PRG-1801 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Purpura, Thrombocytopenic, Idiopathic.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          July 25, 2024

                          Lead Product(s) : PRG-1801

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Recipient : Wuhan Union Hospital

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          CTAD25
                          Not Confirmed
                          CTAD25
                          Not Confirmed

                          Details : PRG-1801 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Lupus Nephritis.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          July 11, 2024

                          Lead Product(s) : PRG-1801

                          Therapeutic Area : Nephrology

                          Highest Development Status : Phase I

                          Recipient : Tongji Hospital

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          CTAD25
                          Not Confirmed
                          CTAD25
                          Not Confirmed

                          Details : PRG-2311 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Lupus Nephritis.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          July 11, 2024

                          Lead Product(s) : PRG-2311

                          Therapeutic Area : Nephrology

                          Highest Development Status : Phase I

                          Recipient : Tongji Hospital

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          CTAD25
                          Not Confirmed
                          CTAD25
                          Not Confirmed

                          Details : PRG-1801 is a drug candidate, which is currently being evaluated in clinical studies for the treatment of Lupus Nephritis.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          February 26, 2024

                          Lead Product(s) : PRG-1801

                          Therapeutic Area : Nephrology

                          Highest Development Status : Undisclosed

                          Sponsor : Lingli Dong

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          CTAD25
                          Not Confirmed
                          CTAD25
                          Not Confirmed

                          Details : BCMA CAR-NK Cell is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Multiple Myeloma.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          December 15, 2022

                          Lead Product(s) : BCMA CAR-NK Cell

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          CTAD25
                          Not Confirmed
                          CTAD25
                          Not Confirmed

                          Details : ALLOB (allogeneic bone cell therapy) is an allogeneic osteoblastic cell therapy product derived from ex vivo cultured bone marrow cells. It represents a unique, proprietary approach to bone regeneration, which turns undifferentiated stromal cells into bo...

                          Product Name : ALLOB

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : $9.7 million

                          October 07, 2022

                          Lead Product(s) : Allogeneic Osteoblastic Cell,Allogeneic Bone-Forming Cell

                          Therapeutic Area : Orthopedics/Orthopedic Surgery

                          Highest Development Status : Phase II

                          Recipient : Bone Therapeutics

                          Deal Size : $53.6 million

                          Deal Type : Termination

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