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Find Clinical Drug Pipeline Developments & Deals by Phanes Therapeutics
PT217 is a first-in-class native IgG-like bispecific antibody (bsAb) targeting DLL3 and CD4. It is being evaluated for the treatment of patients with extensive-stage small cell lung cancer.
PT886 is a first-in-class native IgG-like bispecific antibody (bsAb) targeting claudin 18.2 and CD47, is being developed for the treatment of patients with gastric, gastroesophageal junction and pancreatic adenocarcinomas.
The collaboration aims to study PT886, a first-in-class bispecific antibody targeting claudin 18.2 and CD47, in combination with Merck's anti-PD-1 therapy, Keytruda (pembrolizumab), in patients with claudin 18.2 positive gastric or gastroesophageal junction adenocarcinomas.
PT217 is a common light chain bispecific antibody discovered through Phanes' research engine and was granted orphan drug designation (ODD) for the treatment of small cell lung cancer by the FDA last year.
PT886 directly kills tumor cells via both the ADCP activity of macrophages and ADCC activity of NK cells, and by targeting both claudin 18.2 and CD47 overexpressed on the surface of tumor cells, it broadens the tumor killing spectrum.
The collaboration will leverage Phanes’ proprietary technology platforms, PACbody and SPECpair, in the evaluation of cell therapies in oncology. The company has its proprietary technology platforms to develop novel biologics that address high unmet medical needs in cancer.
Phanes therapeutics’ first-in-class bispecific antibody, PT886 is an anti-claudin 18.2/anti-CD47 bispecific antibody being developed for gastric and pancreatic cancers.
PT199 is an anti-CD73 monoclonal antibody with a differentiated mechanism of action and is designed to counter the adenosine-mediated immunosuppressive tumor microenvironment (TME).
PT217 is a first-in-class bispecific antibody targeting Delta-like ligand 3 (DLL3) and cluster of differentiation 47 (CD47) being developed for patients with SCLC and other neuroendocrine cancers.
PT199 is an anti-CD73 mAb with a differentiated mechanism of action and is designed to counter the adenosine-mediated immunosuppressive tumor microenvironment (TME).
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