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Find Clinical Drug Pipeline Developments & Deals by Pasithea Therapeutics
PAS-004 is is a small molecule allosteric inhibitor of MEK 1/2. It is being evaluated for the treatment of neurofibromatosis type 1 and other cancer indications.
PAS-004 (CIP-137401) is a macrocyclic MEK 1/2 inhibitor. Currently it is being evaluated for the treatment of patients with MAPK pathway driven advanced solid tumors with a documented RAS, RAF or NF1 mutation or patients who have failed BRAF/MEK inhibition.
PAS-004 is a small molecule allosteric inhibitor of MEK 1/2, which are dual-specificity protein kinases, in the MAPK signaling pathway. It showed positive In vivo preclinical efficacy in NRAS mutation cancer xenograft models.
PAS-004 is a first macrocyclic MEK 1/2 Inhibitor small molecule drug which is being investigated for the treatent of RAS, RAF or NF1 mutated solid tumors.
PAS-003 is a fully humanized proprietary monoclonal antibody targeting α5β1 integrin for the treatment of both sporadic and familial amyotrophic lateral sclerosis (ALS) and other neurological diseases.
PAS-002 is a proprietary engineered DNA plasmid vaccine to tolerize the immune system to GlialCAM which is found in brain’s white matter. GlialCAM shares a component of its structure that mimics an identical component of EBNA-1, playing a critical role in triggering MS.
PAS-004 (CIP-137401) is a small molecule allosteric inhibitor of MEK 1/2 in the Ras-Raf-MEK-ERK signaling pathway, which plays critical roles in the regulation of diverse cellular activities, including cell proliferation, survival, differentiation, and motility.
PAS-003 is a monoclonal antibody targeting alpha5/beta1 integrin for the treatment of Amyotrophic Lateral Sclerosis (ALS) and other neurological diseases. The target, Alpha 5 Beta 1 integrin, and its potential role in ALS is supported by post-mortem human tissue studies.
PAS002 is an engineered DNA plasmid designed to tolerize the immune system to GlialCAM,effectively reduces disease severity, delays onset of illness, while also reducing relapse severity.
Pasithea is developing a monoclonal antibody (mAbs) for the treatment of ALS and other neuroinflammatory disorders. Currently, there is no cure for ALS, and there are no effective treatments to halt or slow the progression of the disease.
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