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            Details:

            Appili to present update on topical formulation of paromomycin, ATI-1801 already shown to be safe and effective against the disfiguring disease, cutaneous leishmaniasis, in Phase 3 study.

            Lead Product(s): Paromomycin

            Therapeutic Area: Infections and Infectious Diseases Product Name: ATI-1801

            Highest Development Status: Phase III Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 02, 2022

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            Details:

            The net proceeds of the Offering will be used primarily for working capital purposes and to fund the development of certain product candidates including ATI-1801 (paromomycin) of the Company.

            Lead Product(s): Paromomycin

            Therapeutic Area: Infections and Infectious Diseases Product Name: ATI-1801

            Highest Development Status: Phase III Product Type: Small molecule

            Partner/Sponsor/Collaborator: Bloom Burton Securities

            Deal Size: $3.5 million Upfront Cash: Undisclosed

            Deal Type: Public Offering May 18, 2022

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            Details:

            The net proceeds of the Offering will be used primarily for working capital purposes and to fund the development of certain product candidates of the Company. Details as to the specific allocation of the proceeds will be disclosed in the Prospectus Supplement.

            Lead Product(s): Paromomycin

            Therapeutic Area: Infections and Infectious Diseases Product Name: ATI-1801

            Highest Development Status: Phase III Product Type: Small molecule

            Partner/Sponsor/Collaborator: Bloom Burton Securities

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Public Offering May 17, 2022

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            Details:

            The study met its primary endpoint, with ATI-1801 administered topically once daily for 20 days demonstrating a significant improvement in the rate of clinical cure of the index lesion compared to vehicle (82% vs 58%; p-value < 0.001).

            Lead Product(s): Paromomycin

            Therapeutic Area: Infections and Infectious Diseases Product Name: ATI-1801

            Highest Development Status: Phase III Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 13, 2022

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