[{"orgOrder":0,"company":"Parion Sciences","sponsor":"Vertex Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Miscellaneous","year":"2016","type":"Inapplicable","leadProduct":"Idrevloride","moa":"Amiloride-sensitive sodium channel, ENaC","graph1":"Genetic Disease","graph2":"Phase II","graph3":"Parion Sciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Parion Sciences \/ Vertex Pharmaceuticals","highestDevelopmentStatusID":"8","companyTruncated":"Parion Sciences \/ Vertex Pharmaceuticals"},{"orgOrder":0,"company":"Parion Sciences","sponsor":"Vertex Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Miscellaneous","year":"2015","type":"Inapplicable","leadProduct":"P-1037","moa":"Amiloride-sensitive sodium channel, ENaC","graph1":"Genetic Disease","graph2":"Phase II","graph3":"Parion Sciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Parion Sciences \/ Vertex Pharmaceuticals","highestDevelopmentStatusID":"8","companyTruncated":"Parion Sciences \/ Vertex Pharmaceuticals"},{"orgOrder":0,"company":"Parion Sciences","sponsor":"Vertex Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Rare Diseases and Disorders","country":"U.S.A","productType":"Miscellaneous","year":"2016","type":"Inapplicable","leadProduct":"Hypertonic Saline","moa":"Electrolyte\/osmotic gradient","graph1":"Rare Diseases and Disorders","graph2":"Phase II","graph3":"Parion Sciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Rare Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Parion Sciences \/ Vertex Pharmaceuticals","highestDevelopmentStatusID":"8","companyTruncated":"Parion Sciences \/ Vertex Pharmaceuticals"},{"orgOrder":0,"company":"Parion Sciences","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Undisclosed","year":"2016","type":"Inapplicable","leadProduct":"P-321","moa":"Undisclosed","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Parion Sciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Solution","sponsorNew":"Parion Sciences \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Parion Sciences \/ Undisclosed"},{"orgOrder":0,"company":"Parion Sciences","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Undisclosed","year":"2016","type":"Inapplicable","leadProduct":"P-321","moa":"Undisclosed","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Parion Sciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Solution","sponsorNew":"Parion Sciences \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Parion Sciences \/ Undisclosed"},{"orgOrder":0,"company":"Parion Sciences","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Undisclosed","year":"2014","type":"Inapplicable","leadProduct":"P-321","moa":"Undisclosed","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Parion Sciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Solution","sponsorNew":"Parion Sciences \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Parion Sciences \/ Undisclosed"},{"orgOrder":0,"company":"Parion Sciences","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Dental and Oral Health","country":"U.S.A","productType":"Undisclosed","year":"2011","type":"Inapplicable","leadProduct":"P-552","moa":"Undisclosed","graph1":"Dental and Oral Health","graph2":"Phase I\/ Phase II","graph3":"Parion Sciences","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Dental & Oral Health","amount2New":0,"dosageForm":"Gargle\/Mouthwash","sponsorNew":"Parion Sciences \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"Parion Sciences \/ Undisclosed"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : Hypertonic Saline is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Ciliary Motility Disorders.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          August 18, 2016

                          Lead Product(s) : Hypertonic Saline

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase II

                          Sponsor : Vertex Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : P-321 is a drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Dry Eye Syndromes.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          July 13, 2016

                          Lead Product(s) : P-321

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : P-321 is a drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Dry Eye Syndromes.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          July 07, 2016

                          Lead Product(s) : P-321

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : Idrevloride is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Cystic Fibrosis.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          March 15, 2016

                          Lead Product(s) : Idrevloride

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase II

                          Sponsor : Vertex Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : P-1037 is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Cystic Fibrosis.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          January 22, 2015

                          Lead Product(s) : P-1037

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase II

                          Sponsor : Vertex Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : P-321 is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Dry Eye Syndromes.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          September 16, 2014

                          Lead Product(s) : P-321

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : P-552 is a drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Xerostomia.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          June 09, 2011

                          Lead Product(s) : P-552

                          Therapeutic Area : Dental and Oral Health

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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