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Find Clinical Drug Pipeline Developments & Deals by ORIC Pharmaceuticals
The net proceeds will fund the research and development of company's clinical-stage product, including ORIC-533 small molecule inhibitor of CD73, a key node in the adenosine pathway used to resistance to chemotherapy and immunotherapy-based treatment regimens.
ORIC-944 is a potent and selective allosteric inhibitor of PRC2. It is under phase 1 clinical development for the treatment of metastatic prostate cancer.
ORIC-533 is a highly potent, orally bioavailable small molecule inhibitor of CD73. It is being evaluated under Phase 1 clinical development for the treatment of patients with relapsed/refractory multiple myeloma.
ORIC-114 is a highly selective, brain penetrant, orally bioavailable, irreversible inhibitor designed to selectively target EGFR and HER2 with high potency against exon 20 insertion mutations non-small cell lung cancer.
The net proceeds will be used to fund the development of ORIC-114, a brain penetrant inhibitor designed to selectively target EGFR and HER2 with high potency against exon 20 insertion mutations, being developed across multiple genetically defined cancers.
ORIC-533, is an orally bioavailable small molecule inhibitor of CD73 that has demonstrated more potent adenosine inhibition in vitro compared to an antibody-based approach, and single agent activity in myeloma model systems.
ORIC-533 is a highly potent, orally bioavailable small molecule inhibitor of CD73, a key node in the adenosine pathway believed to play a central role in resistance to chemotherapy and immunotherapy-based treatment regimens.
In autologous ex vivo assays using bone marrow aspirates from patients with relapsed refractory multiple myeloma, ORIC-533 overcame immune suppression and triggered significant lysis of multiple myeloma cells across all dose levels tested and in a dose-responsive manner.
The results demonstrate that single agent ORIC-533 potently inhibits the adenosine pathway, which restores anti-tumor immunity and therefore holds potential as a treatment for patients with multiple myeloma.
Results demonstrate that the ORIC-533, small molecule CD73 inhibitor potently inhibits the adenosine pathway, which restores anti-tumor immunity and therefore holds potential for patients with multiple myeloma.
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