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SA","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"FRANCE","productType":"HPAPI","year":"2020","type":"Inapplicable","leadProduct":"Bimatoprost","moa":"Prostanoid FP receptor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Nicox SA","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Solution","sponsorNew":"Nicox SA \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Nicox SA \/ Inapplicable"},{"orgOrder":0,"company":"Laboratoires Thea","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"FRANCE","productType":"HPAPI","year":"2021","type":"Inapplicable","leadProduct":"Bimatoprost","moa":"Prostanoid FP receptor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Laboratoires Thea","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Solution","sponsorNew":"Laboratoires Thea \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Laboratoires Thea \/ Inapplicable"},{"orgOrder":0,"company":"Nicox SA","sponsor":"Kowa Company","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"FRANCE","productType":"HPAPI","year":"2025","type":"Licensing Agreement","leadProduct":"Bimatoprost","moa":"Prostanoid FP receptor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Nicox SA","amount2":0.029999999999999999,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0.029999999999999999,"dosageForm":"Solution","sponsorNew":"Nicox SA \/ Kowa Company","highestDevelopmentStatusID":"10","companyTruncated":"Nicox SA \/ Kowa Company"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : NCX 470, Nicox’s lead clinical product candidate, is a novel NO-donating bimatoprost eye drop, currently in Phase 3 clinical development in patients with open-angle glaucoma or ocular hypertension.

                          Product Name : NCX 470

                          Product Type : HPAPI

                          Upfront Cash : Undisclosed

                          August 05, 2025

                          Lead Product(s) : Bimatoprost

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Kowa Company

                          Deal Size : $32.8 million

                          Deal Type : Licensing Agreement

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                          02

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : Lumevoq (lenadogene nolparvovec) is a gene therapy developed by GenSight Biologics to treat vision loss in Leber Hereditary Optic Neuropathy (LHON) patients.

                          Product Name : Lumevoq

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          June 12, 2025

                          Lead Product(s) : Lenadogene Nolparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : ANSM

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          03

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : Under the licensing agreement, Kowa holds the Japanese rights to research & development and commercialize NCX 470 (bimatoprost). It is being evaluated for the treatment of ocular hypertension.

                          Product Name : Undisclosed

                          Product Type : HPAPI

                          Upfront Cash : $3.2 million

                          May 27, 2025

                          Lead Product(s) : Bimatoprost

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Kowa Company

                          Deal Size : $32.8 million

                          Deal Type : Licensing Agreement

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                          04

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          March 24, 2025

                          Lead Product(s) : Sepofarsen

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Sepul Bio

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : NCX 470 is a novel NO-donating bimatoprost eye drop which is currently under development for the lowering of IOP in patients with open-angle glaucoma or ocular hypertension.

                          Product Name : Undisclosed

                          Product Type : HPAPI

                          Upfront Cash : Inapplicable

                          March 19, 2025

                          Lead Product(s) : Bimatoprost

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : NCX 470 is a novel NO-donating bimatoprost eye drop which is currently under development for the lowering of IOP in patients with open-angle glaucoma or ocular hypertension.

                          Product Name : Undisclosed

                          Product Type : HPAPI

                          Upfront Cash : Inapplicable

                          March 03, 2025

                          Lead Product(s) : Bimatoprost

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : Lumevoq (lenadogene nolparvovec) is a recombinant rAAV2/2 investigational gene therapy containing the wild-type ND4 gene. It is being evaluated for the treatment of leber hereditary optic neuropathy.

                          Product Name : Lumevoq

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          February 12, 2025

                          Lead Product(s) : Lenadogene Nolparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : NCX 470 is a novel NO-donating bimatoprost eye drop which is currently under development for the lowering of IOP in patients with open-angle glaucoma or ocular hypertension.

                          Product Name : Undisclosed

                          Product Type : HPAPI

                          Upfront Cash : Inapplicable

                          December 02, 2024

                          Lead Product(s) : Bimatoprost

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : Lumevoq (lenadogene nolparvovec) is a recombinant adeno-associated viral vector serotype 2, investigational gene therapy being evaluated for the treatment of leber hereditary optic neuropathy.

                          Product Name : Lumevoq

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          November 13, 2024

                          Lead Product(s) : Lenadogene Nolparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : Kowa will develop and commercialize NCX470 (bimatoprost) for lowering intraocular pressure in glaucoma patients under a recent agreement with Nicox.

                          Product Name : Undisclosed

                          Product Type : HPAPI

                          Upfront Cash : $3.2 million

                          August 02, 2024

                          Lead Product(s) : Bimatoprost

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Kowa Pharmaceuticals America

                          Deal Size : $32.8 million

                          Deal Type : Licensing Agreement

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