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[{"orgOrder":0,"company":"Oxurion","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Oxurion NV Reports First Patient Dosed in Phase 2 Study Evaluating THR-149 for Treatment of Diabetic Macular Edema (DME)","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Phase II","country":"BELGIUM","productType":"Peptide","productStatus":"New Molecular Entity","date":"September 2020","url1":"","url2":"","graph1":"Peptide","graph2":"Oxurion"},{"orgOrder":0,"company":"Oxurion","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Oxurion NV to Present at Wet AMD and DME Drug Development Summit","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Phase II","country":"BELGIUM","productType":"Small molecule","productStatus":"New Molecular Entity","date":"April 2021","url1":"","url2":"","graph1":"Small 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versus aflibercept for Treatment of Diabetic Macular Edema (DME)","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Phase II","country":"BELGIUM","productType":"Small molecule","productStatus":"New Molecular Entity","date":"November 2021","url1":"","url2":"","graph1":"Small molecule","graph2":"Oxurion"},{"orgOrder":0,"company":"Oxurion","sponsor":"Kreos Capital","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"OXURION NV Secures EUR 10 Million Convertible Bond Financing from Kreos Capital and Pontifax Ventures","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Phase II","country":"BELGIUM","productType":"Small molecule","productStatus":"New Molecular Entity","date":"November 2021","url1":"","url2":"","graph1":"Small molecule","graph2":"Oxurion"},{"orgOrder":0,"company":"Oxurion","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Oxurion Provides 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            Details:

            The financing will be used for the development of THR-149, a bicyclic peptide that selectively inhibits human plasma kallikrein, for the treatment of patients with diabetic macular edema.

            Lead Product(s): THR-149

            Therapeutic Area: Ophthalmology Product Name: THR-149

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Atlas Special Opportunities

            Deal Size: $3.7 million Upfront Cash: Undisclosed

            Deal Type: Financing September 18, 2023

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            The financing from the agreement will enable Oxurion to progress the Phase 2, Part B KALAHARI trial of THR-149, a potent PKal inhibitor, in Diabetic Macular Edema (DME).

            Lead Product(s): THR-149

            Therapeutic Area: Ophthalmology Product Name: THR-149

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Atlas Special Opportunities

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Agreement September 11, 2023

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            The financing will be used for the development of THR-149, a bicyclic peptide that selectively inhibits human plasma kallikrein, for the treatment of patients with diabetic macular edema.

            Lead Product(s): THR-149

            Therapeutic Area: Ophthalmology Product Name: THR-149

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Atlas Special Opportunities

            Deal Size: $1.0 million Upfront Cash: Undisclosed

            Deal Type: Financing August 11, 2023

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            Under the agreement, VIB acquired Oxurion's preclinical oncology asset and will use the upfront in the development of THR-149, being evaluated in a Phase 2 clinical trial as a potential treatment for of diabetic macular edema.

            Lead Product(s): THR-149

            Therapeutic Area: Ophthalmology Product Name: THR-149

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: VIB

            Deal Size: $32.4 million Upfront Cash: $0.4 million

            Deal Type: Licensing Agreement July 24, 2023

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            Details:

            The net proceeds will be used to fund the Phase 2, KALAHARI trial evaluating Oxurion’s THR-149, a bicyclic peptide that selectively inhibits human plasma kallikrein, for treating the up to 50% of patients with diabetic macular edema (DME).

            Lead Product(s): THR-149

            Therapeutic Area: Ophthalmology Product Name: THR-149

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Atlas Special Opportunities

            Deal Size: $22.7 million Upfront Cash: Undisclosed

            Deal Type: Financing June 15, 2023

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            Details:

            THR-149 is a bicyclic peptide that selectively inhibits human plasma kallikrein (PKal) with an inhibition constant of 0.22 nM. THR-149 is currently being evaluated for Diabetic Macular Edema.

            Lead Product(s): THR-149

            Therapeutic Area: Ophthalmology Product Name: THR-149

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 12, 2023

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            Details:

            THR-149 is a bicyclic peptide that selectively inhibits human plasma kallikrein (PKal) with an inhibition constant of 0.22 nM. Through the inhibition of the kallikrein-kinin system (KKS), THR-149 prevents the induction of retinal vascular permeability and inflammation.

            Lead Product(s): THR-149

            Therapeutic Area: Ophthalmology Product Name: THR-149

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 25, 2023

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            Details:

            The financing will be used to progress towards finishing patient recruitment for the Phase 2, Part B KALAHARI trial evaluating Oxurion’s THR-149 for treating the up to 50% of patients with diabetic macular edema (DME).

            Lead Product(s): THR-149

            Therapeutic Area: Ophthalmology Product Name: THR-149

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Atlas Special Opportunities

            Deal Size: $22.4 million Upfront Cash: Undisclosed

            Deal Type: Financing May 22, 2023

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            Details:

            The financing will be used to fund the Phase 2, Part B KALAHARI trial evaluating Oxurion’s THR-149, a bicyclic peptide that selectively inhibits human plasma kallikrein (PKal), for treating the patients with diabetic macular edema (DME).

            Lead Product(s): THR-149

            Therapeutic Area: Ophthalmology Product Name: THR-149

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Atlas Special Opportunities

            Deal Size: $3.0 million Upfront Cash: Undisclosed

            Deal Type: Funding March 20, 2023

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            Details:

            THR-149 is a bicyclic peptide that selectively inhibits human plasma kallikrein (PKal) with an inhibition constant of 0.22 nM. Through the inhibition of the kallikrein-kinin system (KKS), THR-149 prevents the induction of retinal vascular permeability and inflammation.

            Lead Product(s): THR-149

            Therapeutic Area: Ophthalmology Product Name: THR-149

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 14, 2023

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