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            Vabysmo (faricimab-svoa) is the first bispecific antibody which targets and inhibits two signalling pathways linked to a number of vision-threatening retinal conditions by neutralising Ang-2 and VEGF-A. It is being indicated for the treatment of retinal vein occlusion.

            Lead Product(s): Faricimab-svoa

            Therapeutic Area: Ophthalmology Product Name: Vabysmo

            Highest Development Status: Approved Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 27, 2023

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            Novartis will focus on other therapeutic areas, like retinal diseases via platforms including gene therapy and optogenetics through divestment of Xiidra (lifitegrast), the first approved treatment for dry eye disease, and SAF312 (libvatrep), for chronic ocular surface pain.

            Lead Product(s): Lifitegrast

            Therapeutic Area: Ophthalmology Product Name: Xiidra

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Bausch & Lomb Incorporated

            Deal Size: $2,500.0 million Upfront Cash: $1,750.0 million

            Deal Type: Divestment September 29, 2023

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            Novartis will focus on other therapeutic areas, like retinal diseases via platforms including gene therapy and optogenetics through divestment of Xiidra (lifitegrast), the first approved treatment for dry eye disease, and SAF312 (libvatrep), for chronic ocular surface pain.

            Lead Product(s): Lifitegrast

            Therapeutic Area: Ophthalmology Product Name: Xiidra

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Bausch & Lomb Incorporated

            Deal Size: $2,500.0 million Upfront Cash: $1,750.0 million

            Deal Type: Divestment June 30, 2023

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            Ilevro® (nepafenac ophthalmic suspension) is a 0.3%, a non-steroidal, anti-inflammatory eye drop indicated for pain and inflammation associated with cataract surgery.

            Lead Product(s): Nepafenac

            Therapeutic Area: Ophthalmology Product Name: Ilevro

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: Harrow

            Deal Size: $175.0 million Upfront Cash: Undisclosed

            Deal Type: Acquisition December 14, 2022

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            Vabysmo (faricimab), a bispecific antibody, is uniquely engineered to target and inhibit two disease pathways, linked to a number of vision-threatening retinal conditions, by neutralising Ang-2 and VEGF-A, to restore vascular stability.

            Lead Product(s): Faricimab

            Therapeutic Area: Ophthalmology Product Name: Vabysmo

            Highest Development Status: Approved Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 19, 2022

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            Details:

            CHMP recommendation is based on results across four phase III studies which showed that people treated with Vabysmo (faricimab) at intervals of up to four months achieved non-inferior vision gains versus aflibercept given every two months.

            Lead Product(s): Faricimab

            Therapeutic Area: Ophthalmology Product Name: Vabysmo

            Highest Development Status: Approved Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable July 22, 2022

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            More than 60% of people receiving Vabysmo (faricimab) could be treated every four months – an increase of over 15 percentage points since the primary analysis at one year – while achieving comparable vision gains versus aflibercept given every two months.

            Lead Product(s): Faricimab

            Therapeutic Area: Ophthalmology Product Name: Vabysmo

            Highest Development Status: Approved Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable July 14, 2022

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            Details:

            Patients treated with BEOVU (brolucizumab) in KESTREL and KITE demonstrated a significant reduction from baseline in central subfield thickness (CST) starting at week four and continuing up to week 52.

            Lead Product(s): Brolucizumab

            Therapeutic Area: Ophthalmology Product Name: Beovu

            Highest Development Status: Approved Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 01, 2022

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            Brimonidine tartrate and timolol maleate ophthalmic solution, 0.2%/0.5% is an alpha-adrenergic receptor agonist with a betaadrenergic receptor inhibitor indicated for the reduction of elevated intraocular pressure (IOP) in patients with ocular hypertension.

            Lead Product(s): Brimonidine Tartrate,Timolol Maleate

            Therapeutic Area: Ophthalmology Product Name: Brimonidine Tartarate/Timolol Maleate-Generic

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator:

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 14, 2022

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            Details:

            Beovu (brolucizumab, also known as RTH258) 6 mg is approved for the treatment of wet age-related macular degeneration (AMD) in more than 70 countries, including in the US, EU, UK, Japan, Canada and Australia.

            Lead Product(s): Brolucizumab

            Therapeutic Area: Ophthalmology Product Name: Beovu

            Highest Development Status: Approved Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 31, 2022

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