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            Details:

            ONL1204 is a novel, first-in-class small molecule Fas inhibitor designed to protect key retinal cells, including photoreceptors, from cell death that occurs across a range of retinal diseases and conditions.

            Lead Product(s): ONL1204

            Therapeutic Area: Ophthalmology Product Name: ONL1204

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 28, 2023

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            Details:

            ONL1204 is a novel, Fas inhibitor designed to protect key retinal cells, including photoreceptors, from cell death that occurs across a range of retinal diseases and conditions. It is being investigated in patients with macula-off rhegmatogenous retinal detachment.

            Lead Product(s): ONL1204

            Therapeutic Area: Ophthalmology Product Name: ONL1204

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 12, 2023

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            Details:

            Proceeds from the financing will primarily support the advancement of ONL1204 Ophthalmic Solution, a novel, first-in-class small molecule Fas inhibitor, into a Phase 2 clinical trial in patients with macula-off rhegmatogenous retinal detachment (RRD).

            Lead Product(s): ONL1204

            Therapeutic Area: Ophthalmology Product Name: ONL1204

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Bios Partners

            Deal Size: $15.0 million Upfront Cash: Undisclosed

            Deal Type: Series C Financing March 08, 2023

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            Details:

            ONL1204 is a novel, first-in-class small molecule Fas inhibitor designed to protect key retinal cells, including photoreceptors, from cell death that occurs across a range of retinal diseases and conditions.

            Lead Product(s): ONL1204

            Therapeutic Area: Ophthalmology Product Name: ONL1204

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 13, 2023

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            Details:

            ONL1204 is a novel, first-in-class small molecule Fas inhibitor designed to protect key retinal cells, including photoreceptors, from cell death that occurs across a range of retinal diseases and conditions.

            Lead Product(s): ONL1204

            Therapeutic Area: Ophthalmology Product Name: ONL1204

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 01, 2023

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            Details:

            ONL1204 is a novel, first-in-class small molecule Fas inhibitor designed to protect key retinal cells, including photoreceptors, from cell death that occurs across a range of retinal diseases and conditions.

            Lead Product(s): ONL1204

            Therapeutic Area: Ophthalmology Product Name: ONL1204

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 26, 2023

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            Details:

            ONL1204 Ophthalmic Solution is a novel, first-in-class small peptide Fas inhibitor designed to protect key retinal cells, including photoreceptors, from cell death that occurs in a range of retinal diseases and conditions.

            Lead Product(s): ONL1204

            Therapeutic Area: Ophthalmology Product Name: ONL1204

            Highest Development Status: IND Enabling Product Type: Small molecule

            Recipient: AmbioPharm

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable July 12, 2022

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            Details:

            This funding supports the completion of a Phase 1 study in retinal detachment with ONL’s lead compound ONL1204. In addition, the funding will advance ONL1204 in two chronic indications, glaucoma and dry age-related macular degeneration.

            Lead Product(s): ONL1204

            Therapeutic Area: Ophthalmology Product Name: ONL1204

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Bios Partners

            Deal Size: $46.9 million Upfront Cash: Undisclosed

            Deal Type: Series B Financing December 22, 2020

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