
 
													 
									 
															 
															Year
 
															DEALS // DEV.
 
															Country
 
															 
															Therapeutic Area
 
															Study Phase
 
															Deal Type
 
															Product Type
 
															Dosage Form
 
															Lead Product
 
															Target

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Lead Product(s) : OKI-219,Fulvestrant
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
OnKure Announces Preliminary Safety Data from PIKture-01 Trial of OKI-219
Details : OKI-219 is a PI3K alpha H1047R inhibitor small molecule drug candidate, which is currently being evaluated for the treatment of patients with solid tumors.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
December 10, 2024
Lead Product(s) : OKI-219,Fulvestrant
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : OKI-219,Fulvestrant
Therapeutic Area : Oncology
Study Phase : Phase I
Recipient : Reneo Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Merger
OnKure Closes Merger with Reneo Pharmaceuticals, Raises $65 Million
Details : The combined company will focus on OnKure’s candidates targeting oncogenic mutations in PI3K alpha, including OKI-219, which is in Phase 1 for the treatment of solid tumors.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
October 04, 2024
Lead Product(s) : OKI-219,Fulvestrant
Therapeutic Area : Oncology
Highest Development Status : Phase I
Recipient : Reneo Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Merger

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Lead Product(s) : OKI-219,Fulvestrant
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Leerink Partners
Deal Size : $65.0 million
Deal Type : Private Placement
OnKure Closes Merger with Reneo Pharmaceuticals, Raises $65 Million
Details : The combined company will focus on OnKure’s candidates targeting oncogenic mutations in PI3K alpha, including OKI-219, which is in Phase 1 for the treatment of solid tumors.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
October 04, 2024
Lead Product(s) : OKI-219,Fulvestrant
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Leerink Partners
Deal Size : $65.0 million
Deal Type : Private Placement

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Lead Product(s) : OKI-219,Fulvestrant
Therapeutic Area : Oncology
Study Phase : Phase I
Recipient : Reneo Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Merger
Reneo Pharmaceuticals and OnKure Announce Proposed Merger
Details : The combined company will advance OnKure’s pipeline targeting oncogenic mutations in PI3K alpha, including its lead program OKI-219, which is in Phase 1 trial for the treatment of solid tumors.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
May 13, 2024
Lead Product(s) : OKI-219,Fulvestrant
Therapeutic Area : Oncology
Highest Development Status : Phase I
Recipient : Reneo Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Merger

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Lead Product(s) : OKI-219,Fulvestrant
Therapeutic Area : Oncology
Study Phase : Phase I
Recipient : Reneo Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Merger
Reneo Pharmaceuticals and OnKure Announce Proposed Merger
Details : The combined company will focus on advancing OnKure’s pipeline candidates targeting oncogenic mutations in PI3Kα, including its lead program OKI-219, currently in Phase 1 for solid tumors.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
May 13, 2024
Lead Product(s) : OKI-219,Fulvestrant
Therapeutic Area : Oncology
Highest Development Status : Phase I
Recipient : Reneo Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Merger

First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer
Details : OKI-219 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Neoplasms.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
February 02, 2024

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Lead Product(s) : OKI-219
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
OnKure Announces IND Clearance by FDA Enabling Phase 1 Initiation for OKI-219
Details : OKI-219 is a potential best-in-class, orally bioavailable, highly selective inhibitor of PI3Kα H1047R, which is being evaluated for the treatment of HER2+/ PI3Kα H1047R breast cancer.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
January 04, 2024
Lead Product(s) : OKI-219
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : OKI-219
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Surveyor Capital
Deal Size : $54.0 million
Deal Type : Series C Financing
OnKure Therapeutics Announces $54 Million Series C Financing
Details : The proceeds will be used to support the continued development of OnKure’s differentiated pipeline of next generation precision medicines, including the advancement of its lead discovery program OKI-219, a selective PI3K alpha H1047R inhibitor, into th...
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
May 23, 2023
Lead Product(s) : OKI-219
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Surveyor Capital
Deal Size : $54.0 million
Deal Type : Series C Financing

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Lead Product(s) : OKI-179,Binimetinib
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : OKI-179 is a novel, oral Class I histone deacetylase (HDAC) inhibitor for the potential treatment of a wide range of solid and hematological malignancies.
Product Name : Undisclosed
Product Type : Peptide, Unconjugated
Upfront Cash : Inapplicable
June 02, 2022
Lead Product(s) : OKI-179,Binimetinib
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : OKI-179
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : OKI-179 is a Peptide drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Melanoma.
Product Name : Undisclosed
Product Type : Peptide, Unconjugated
Upfront Cash : Inapplicable
April 22, 2022
Lead Product(s) : OKI-179
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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