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Find Clinical Drug Pipeline Developments & Deals by ONK Therapeutics

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : The partnership aims to explore the combination of ONK’s ONKT105, CISH + TGFβR2 double knock-out (KO), sIL-15 knock-in (KI) allogeneic NK cell therapy with NAYA’s GPC3-targeted NY-303 FLEX-NK™ bispecific antibody for the treatment of cancer.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          June 12, 2023

                          Lead Product(s) : ONKT105,NY-303

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Naya Biosciences

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          02

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : ONKT102 is the company’s most advanced program, and is being advanced towards clinical development as a potential treatment for patients with relapsed or refractory multiple myeloma (MM).

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          August 29, 2022

                          Lead Product(s) : ONKT102

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : The financing will enable ONK to maintain its strong momentum as it advances pre-clinical programs including ONKT102, through comprehensive IND-enabling studies, including in-vivo proof-of-concept models across multiple programs.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          June 01, 2022

                          Lead Product(s) : ONKT102

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Acorn Bioventures

                          Deal Size : $21.5 million

                          Deal Type : Series A Financing

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                          04

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : ONKT102 combines an optimized affinity CD38 CAR and a TRAILv targeting DR5, intended for the treatment of patients with relapsed/refractory multiple myeloma.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          September 09, 2021

                          Lead Product(s) : ONKT102

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : ONKT103 an engineering NK cells to better treat cancer by increasing their resistance to the adverse metabolic conditions generated by tumors.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          August 06, 2021

                          Lead Product(s) : ONKT103

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Recipient : Trinity College Dublin

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          06

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Study Phase : Preclinical

                          Recipient : Walter and Eliza Hall Institute of Medical Research

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

                          Details : Under the terms of the agreement, ONK Therapeutics has secured exclusive global rights to WEHI’s patent covering the use of human NK cells lacking CISH for the purposes of researching, developing, manufacturing and commercializing NK cell therapies.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          May 27, 2021

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : Walter and Eliza Hall Institute of Medical Research

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          07

                          SCI Medicinal Chemistry
                          Not Confirmed
                          SCI Medicinal Chemistry
                          Not Confirmed

                          Details : License provides a consistent supply of scalable and ethically-sourced umbilical cord blood and cord-derived NK cells which, in combination with the EBV-LCL feeder layer, will provide the critical starting material for its off-the-shelf cell therapy manu...

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          March 18, 2021

                          Lead Product(s) : ONKT101

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Recipient : National Institutes of Health

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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