Drugs in Dev.
Oncology
Preclinical
Israel 
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Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Silexion Therapeutics Confirms Pan-KRAS Activity of SIL204 with Up to 99.7% Inhibition
Details : SIL-204, an oligonucleotide targeting KRAS G12D/V, shows promising results in treating undisclosed Key Focus Area.
Product Name : SIL204
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
September 30, 2025
Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : H.C. Wainwright & Co
Deal Size : $6.0 million
Deal Type : Public Offering
Silexion Therapeutics Announces Pricing of $6.0 Million Public Offering
Details : The net proceeds will be used to advance the Company’s pre-clinical studies, including SIL-204, encapsulated in biodegradable PLGA MP, for direct release and injection into KRAS mutated solid tumors.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Undisclosed
September 11, 2025
Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : H.C. Wainwright & Co
Deal Size : $6.0 million
Deal Type : Public Offering

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Lead Product(s) : SIL204
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Silexion Wraps Up Preclinical Studies of SIL204 for Lung and Colorectal Cancer
Details : Silexion is also advancing its next-generation siRNA candidate, SIL204, designed to target a broader range of KRAS mutations and showing significant potential in preclinical studies.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
May 21, 2025
Lead Product(s) : SIL204
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Aramchol meglumine
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Virginia Commonwealth University
Deal Size : Undisclosed
Deal Type : Collaboration
Galmed Pharmaceuticals Launches VCU Collaboration to Tackle Drug Resistance in GI Cancers
Details : The collaboration aims to evaluate Aramchol's (aramchol meglumine) effect on overcoming drug resistance in gastrointestinal (GI) cancers.
Product Name : Aramchol
Product Type : Miscellaneous
Upfront Cash : Undisclosed
April 17, 2025
Lead Product(s) : Aramchol meglumine
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Virginia Commonwealth University
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Silexion Reports Positive SIL204 Data in Pancreatic Cancer Models
Details : SIL204 is an innovative RNA interference (RNAi) therapies, which is currently being evaluated for the treatment of solid tumors driven by KRAS mutations.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
March 05, 2025
Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Silexion Completes Study on SIL-204 in Orthotopic Pancreatic Cancer Models
Details : SIL 204 is an anti KRAS G12D/V short-interfering RNA, which is being evaluated for KRAS G12D/V-mutated pancreatic neoplasms.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
February 25, 2025
Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Silexion Reports SIL-204 Reduces Pancreatic Tumor Growth
Details : SIL-204 is a next-generation siRNA therapeutic candidate administered subcutaneously inhibited tumor growth in KRAS G12D/V-mutated pancreatic neoplasms mouse models.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
January 28, 2025
Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : H.C. Wainwright & Co
Deal Size : $5.0 million
Deal Type : Public Offering
Silexion Therapeutics Announces Pricing of $5.0 Million Public Offering
Details : The net proceeds from the offering will advance the Company’s pre-clinical studies of SIL-204, which is being evaluated for KRAS G12D/V-mutated Pancreatic Neoplasms.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Undisclosed
January 15, 2025
Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : H.C. Wainwright & Co
Deal Size : $5.0 million
Deal Type : Public Offering

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Lead Product(s) : SIL-204,Fluorouracil,Irinotecan Hydrochloride
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Silexion’s SIL-204 Shows Synergy With Pancreatic Cancer Chemotherapy
Details : SIL 204 is an anti K-ras G12D/V short-interfering RNA, which is being evaluated for KRAS G12D/V-mutated Pancreatic neoplasms in combination with 5-fluorouracil and irinotecan.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
January 15, 2025
Lead Product(s) : SIL-204,Fluorouracil,Irinotecan Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
SciSparc’s MitoCareX Expands Research to Pancreatic Cancer
Details : Company works on cancer therapeutics targeting the mitochondrial SLC25 protein family, recently achieved positive results using pancreatic cancer cell lines.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Inapplicable
January 07, 2025
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
