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Find Oncology Drugs in Phase II Clinical Development in SPAIN

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            ORY-1001 (Iadademstat) is a small oral molecule, which acts as a highly selective inhibitor of the epigenetic enzyme LSD1 and has a powerful differentiating effect in hematologic cancers

            Lead Product(s): Iadademstat,Paclitaxel

            Therapeutic Area: Oncology Product Name: ORY-1001

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 18, 2023

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            Under the terms of the agreement, Oryzon and the NCI will collaborate on potential further clinical development of Oryzon’s clinical stage LSD1 inhibitor, iadademstat, in different types of solid and hematological cancers.

            Lead Product(s): Iadademstat,Paclitaxel

            Therapeutic Area: Oncology Product Name: ORY-1001

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: National Cancer Institute

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration July 19, 2022

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            Evidence of clinical efficacy continues to be robust and consistent with previously reported data for ORY-1001 (Iadademstat), with an objective response rate (ORR) of 81% (22 of 27 evaluable patients); of these, 64% were complete remissions and 36% partial remissions.

            Lead Product(s): Iadademstat,Azacitidine

            Therapeutic Area: Oncology Product Name: ORY-1001

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 10, 2022

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            Iadademstat (ORY-1001), is an oral, highly potent and selective inhibitor of the epigenetic enzyme LSD1, a chromatin remodeler that interacts with a variety of transcription factors involved in SCLC, other solid tumors and hematological cancers such as acute myeloid leukemia.

            Lead Product(s): Iadademstat,Paclitaxel

            Therapeutic Area: Oncology Product Name: ORY-1001

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 08, 2022

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            The funding is for Oryzon’s project, Iadademstat (ORY-1001) a small oral molecule, which acts as a highly selective inhibitor of the epigenetic enzyme LSD1 and has a powerful differentiating effect in hematologic cancers.

            Lead Product(s): Iadademstat,Azacitidine

            Therapeutic Area: Oncology Product Name: ORY-1001

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: European Commission

            Deal Size: $2.0 million Upfront Cash: Undisclosed

            Deal Type: Funding June 07, 2022

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            BO-112 is a best-in-class RNA-based therapy which has been demonstrated to initiate a powerful immune response, leveraging a unique multi-target approach to turn 'cold' tumors 'hot' and therefore visible to the immune system.

            Lead Product(s): BO-112,Pembrolizumab

            Therapeutic Area: Oncology Product Name: BO-112

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 15, 2022

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            The combination of iadademstat with azacitidine continues to show a good safety profile, with only two serious adverse events reported as probably related to treatment.

            Lead Product(s): Iadademstat,Azacitidine

            Therapeutic Area: Oncology Product Name: ORY-1001

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 13, 2021

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            Iadademstat (ORY-1001) is a small oral molecule, which acts as a highly selective inhibitor of the epigenetic enzyme LSD1 and has a powerful differentiating effect in hematologic cancers. Robust signals of clinical efficacy, with ORR of 83%, of which 67% are CR/CRi.

            Lead Product(s): Iadademstat,Azacitidine

            Therapeutic Area: Oncology Product Name: ORY-1001

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 11, 2021

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            Details:

            Presentation will cover Phase IIa open-label clinical study of intratumoral administration of BO-112 in combination with pembrolizumab in subjects with liver metastasis from colorectal cancer or gastric/gastro-oesophageal junction cancer.

            Lead Product(s): BO-112,Pembrolizumab

            Therapeutic Area: Oncology Product Name: BO-112

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 14, 2021

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            Trial will examine administration of Highlight's BO-112 in combination with an anti-PD1 in unresectable or metastatic melanoma patients.

            Lead Product(s): BO-112,Pembrolizumab

            Therapeutic Area: Oncology Product Name: BO-112

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Merck & Co

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 02, 2021

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