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BioNTech"},{"orgOrder":0,"company":"BioNTech","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"GERMANY","productType":"Vaccine","year":"2022","type":"Inapplicable","leadProduct":"BNT113","moa":"||Undisclosed","graph1":"Oncology","graph2":"Phase II","graph3":"BioNTech","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"BioNTech \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"BioNTech \/ Inapplicable"},{"orgOrder":0,"company":"BioNTech","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"GERMANY","productType":"Vaccine","year":"2024","type":"Inapplicable","leadProduct":"BNT111","moa":"||Immunostimulant","graph1":"Oncology","graph2":"Phase II","graph3":"BioNTech","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"BioNTech \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"BioNTech \/ Inapplicable"}]

Find Oncology Drugs in Phase II Clinical Development in GERMANY

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                          Top Deals by Deal Size (USD bn)

                          01

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : AFM13 (acimtamig) is a CD16a & CD30 inhibitor innate cell engager, which is being evaluated in combination with AlloNK (AB-101) for the treatment of relapsed or refractory Hodgkin Lymphoma.

                          Product Name : AFM13

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          December 05, 2024

                          Lead Product(s) : Acimtamig,AB-101,Cyclophosphamide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : The funding will support TME Pharma’s planned Phase 2 study evaluating its lead asset, the CXCL12 inhibitor NOX-A12, for use in the treatment of aggressive adult brain cancer, glioblastoma.

                          Product Name : NOX-E36

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          October 31, 2024

                          Lead Product(s) : Emapticap pegol

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : BMBF

                          Deal Size : $2.6 million

                          Deal Type : Funding

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                          03

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : BNT111 is an mRNA-based off-the-shelf cancer immunotherapy candidate. It is being evaluated for the treatment of patients with unresectable stage III or IV melanoma.

                          Product Name : BNT111

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          July 30, 2024

                          Lead Product(s) : BNT111,Cemiplimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : Autogene cevumeran (RO7198457) is a messenger RNA (mRNA)-based personalized cancer vaccine, which is being evaluated in combination with atezolizumab for resected pancreatic ductal adenocarcinoma.

                          Product Name : BNT122

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          July 04, 2024

                          Lead Product(s) : Autogene Cevumeran,Atezolizumab,Oxaliplatin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : Through the termination, responsibility for the continued development and potential commercialization of GEN1046 (acasunlimab), which is being evaluated for PD-L1-positive non small cell lung cancer.

                          Product Name : GEN1046

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          May 08, 2024

                          Lead Product(s) : Acasunlimab,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Genmab

                          Deal Size : Undisclosed

                          Deal Type : Termination

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                          06

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : AFM13 is a first-in-class innate cell engager (ICE®) that uniquely activates the innate immune system to destroy CD30-positive hematologic tumors, which is investigated in combination with AlloNK will be investigated for the treatment of relapsed/refrac...

                          Product Name : AFM13

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          December 09, 2023

                          Lead Product(s) : Acimtamig,AB-101

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : CTL-002 (Visugromab) is a monoclonal antibody that neutralizes the tumor-derived Growth Differentiation Factor-15 (GDF-15) in combination with neoadjuvant immunotherapy (nivolumab, aPD-1 inhibitor) in muscle invasive bladder cancer (MIBC).

                          Product Name : CTL-002

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          October 26, 2023

                          Lead Product(s) : Visugromab,Nivolumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : BNT122 is a mRNA-based individualized neoantigen-specific immunotherapy (iNeST) candidate autogene cevumeran, which is investigated for the treatment of resected pancreatic ductal adenocarcinoma.

                          Product Name : BNT122

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          October 19, 2023

                          Lead Product(s) : Autogene Cevumeran,Atezolizumab,Oxaliplatin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Genentech

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : AFM13 is a first-in-class innate cell engager (ICE®) that uniquely leverags the power of the innate immune system by engaging and activating natural killer (NK) cells and macrophages to destroy CD30-positive hematologic tumors.

                          Product Name : AFM13

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          September 01, 2023

                          Lead Product(s) : Acimtamig

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          IFT FIRST
                          Not Confirmed
                          IFT FIRST
                          Not Confirmed

                          Details : BNT113 is expected to be the first product candidate from a potential wave of novel cancer immunotherapies that BioNTech anticipates to evaluate in the region.

                          Product Name : BNT113

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          December 16, 2022

                          Lead Product(s) : BNT113,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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