CSBio CSBio

X
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Applicable","newsHeadline":"InnoCare Announces Clearance of Clinical Trial of BCL2 Inhibitor ICP-248 by U.S. FDA","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"CHINA","productType":"Small molecule","productStatus":"New Molecular Entity","date":"January 2024","url1":"","url2":"","graph1":"Small molecule","graph2":"InnoCare Pharma"},{"orgOrder":0,"company":"CARsgen Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"CARsgen's CT011 Achieves IND Clearance from the NMPA for the GPC3-positive Stage \u2162a Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"CHINA","productType":"Cell and Gene therapy","productStatus":"New Molecular Entity","date":"January 2024","url1":"","url2":"","graph1":"Cell and Gene therapy","graph2":"CARsgen Therapeutics"},{"orgOrder":0,"company":"InnoCare Pharma","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"InnoCare Announces First Pediatric Patient Dosed in Clinical Trial of pan-TRK Inhibitor Zurletrectinib in China","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"CHINA","productType":"Small molecule","productStatus":"New Molecular Entity","date":"January 2024","url1":"","url2":"","graph1":"Small molecule","graph2":"InnoCare Pharma"},{"orgOrder":0,"company":"Shenzhen Chipscreen Biosciences","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Chipscreen NewWay: First Patient Dosed in Phase 1 Trial of the Bispecific Antibody NWY001, a Next-generation Tumor Immunotherapy in Patients with Advanced Solid Tumors","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"CHINA","productType":"Large molecule","productStatus":"New Molecular Entity","date":"January 2024","url1":"","url2":"","graph1":"Large molecule","graph2":"Shenzhen Chipscreen Biosciences"}]

Find Oncology Drugs in Phase I Clinical Development in CHINA

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            ICP-723 (zurletrectinib) is a pan-TRK inhibitor which markedly inhibits the activity of the wild type TRKA, TRKB and TRKC. It is under phase 1 trials for pediatric patients with age 2 to 12 years old with advanced or metastatic solid tumors, breast cancer & colorectal cancer.

            Lead Product(s): Zurletrectinib

            Therapeutic Area: Oncology Product Name: ICP-723

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 23, 2024

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            ICP-248 is a novel, orally bioavailable, small molecule drug which is BCL2-selective inhibitor. It is currently being evaluated in phase 1 clinical trials for the treatment of B cell malignancy.

            Lead Product(s): ICP-248

            Therapeutic Area: Oncology Product Name: ICP-248

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 15, 2024

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            CT011 is an autologous CAR T-cell product candidate against GPC3. It is currently being evaluated for the treatment of patients with GPC3-positive stage Ⅲa hepatocellular carcinoma.

            Lead Product(s): CT011

            Therapeutic Area: Oncology Product Name: CT011

            Highest Development Status: Phase I Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 15, 2024

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            The financing will advance development of the Company's radiopharmaceutical pipeline, including 225Ac-FL-020, towards Phase I clinical trials in metastatic castration-resistant prostate cancer patients, as well as optimize its proprietary discovery platform, UniRDCTM.

            Lead Product(s): 225Ac-FL-020

            Therapeutic Area: Oncology Product Name: 225Ac-FL-020

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Prosperity7 Ventures

            Deal Size: $47.3 million Upfront Cash: Undisclosed

            Deal Type: Series B Financing January 03, 2024

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            HF1K16 is a unique liposome construct of ATRA, a small molecule metabolite of vitamin A. It is administered by infusion, travels through the blood stream and infiltrates the tumor microenvironment.

            Lead Product(s): Tretinoin

            Therapeutic Area: Oncology Product Name: HF1K16

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 23, 2023

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            Under the agreement, GSK will obtain rights to progress development and commercialisation for HS-20089, a B7-H4 targeted antibody-drug conjugate currently in phase I clinical trials in China, in ovarian and endometrial cancer.

            Lead Product(s): HS-20089

            Therapeutic Area: Oncology Product Name: HS-20089

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: GSK

            Deal Size: $1,570.0 million Upfront Cash: $85.0 million

            Deal Type: Licensing Agreement October 20, 2023

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            TJ-L14B/ABL503, is a differentiated PD-L1 x 4-1BB bispecific antibody, which is investigated in patients with progressive, locally advanced or metastatic solid tumors who are relapsed or refractory following prior lines of treatment.

            Lead Product(s): TJ-L14B

            Therapeutic Area: Oncology Product Name: ABL503

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: ABL Bio

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 10, 2023

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            ES009 specifically binds to a unique epitope on human LILRB2 and potently blocks LILRB2 binding to multiple ligands, which is investigated for the treatment of cancer.

            Lead Product(s): ES009

            Therapeutic Area: Oncology Product Name: ES009

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 26, 2023

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            ABM-1310 is a selective, highly water-soluble, orally active, and brain-penetrant small molecule BRAF inhibitor, which is investigated for the treatment of relapsed and drug resistant primary malignant brain tumors.

            Lead Product(s): ABM-1310

            Therapeutic Area: Oncology Product Name: ABM-1310

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 26, 2023

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            The financing will support Grit Biotechnology's Tumor-Infiltrating Lymphocyte (TIL) pipeline development, including the pivotal Phase II trial for GT101 and the advancement of next-gen gene-edited TIL products.

            Lead Product(s): GT101

            Therapeutic Area: Oncology Product Name: GT101

            Highest Development Status: Phase I Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: CICC

            Deal Size: $60.0 million Upfront Cash: Undisclosed

            Deal Type: Series B Financing September 08, 2023

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