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Find Oncology Drugs in Phase I/II Clinical Development in NORWAY
CyPep-1 is a chemically synthesized peptide with oncolytic properties. It selectively targets cancer cells based on their altered molecular composition and releases tumor neoantigens to the microenvironment which potentially induces an anti-tumour immune response.
The net proceeds will support the progress of Cytovation’s lead asset, CyPep-1, a first-in-class immunotherapy targeting the cell membrane of tumor cells, into a full Phase 2 program for the treatment of solid tumors.
BGB324 (bemcentinib) is a first-in-class, selective, oral once-a-day inhibitor of AXL receptor tyrosine kinase (AXL) a promising therapeutic target for serious diseases. It is being developed for the treament of NSCLC.
Betalutin (177Lu lilotomab satetraxetan), is a next-generation single-dose CD37-directed radioimmunotherapy (RIT) for the treatment of Hodgkin B-cell lymphoma.
Betalutin® (177Lu Lilotomab Satetraxetan), showed signs of efficacy in this frail, elderly and difficult-to-treat patient population, the independent expert panel reported that the efficacy data are less promising than the data reported from the Phase 2a LYMRIT 37-01 trial.
CyPep-1 eliminates cancer cells by forming pores in the plasma membrane, releasing cancer specific antigens to the immune system, promoting an inflammatory microenvironment and inducing a tumor-specific immune response by in situ vaccination.
VB10.16 in combination with atezolizumab demonstrated an ORR of 21%, including 2 CRs and 6 PRs, in a heavily pre-treated population of patients with HPV16-positive advanced cervical cancer.
VB10.16, a therapeutic vaccine and, an immunotherapy for the treatment of human papillomavirus 16 induced malignancies, is in Phase 2 for the treatment of cervical cancer.
The collaboration will enable Cytovation to draw upon RRPF’s extensive knowledge and network in preparation for a Phase I/II study to investigate CyPep-1 in RRP to be initiated in 2H 2022.