Drugs in Dev.
Oncology
IND Enabling
Canada 
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Lead Product(s) : Bria-PROS-Plus
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : National Cancer Institute
Deal Size : $2.0 million
Deal Type : Funding
BriaCell Awarded $2 Million NCI Grant to Advance Bria-PROS+™ in Prostate Cancer
Details : The proceeds will be used to advance Bria-PROS+, BriaCell’s next-generation personalized off-the-shelf immunotherapy for prostate cancer.
Product Name : Bria-PROS-Plus
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
August 25, 2025
Lead Product(s) : Bria-PROS-Plus
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : National Cancer Institute
Deal Size : $2.0 million
Deal Type : Funding

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Lead Product(s) : PQ203
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
FDA Clears Phase I, Fast Track For ProteinQure’s PQ203 In US, Canada
Details : PQ203 is a novel Peptide Drug Conjugate composed of a peptide targeting the Sortilin receptor, being investigated for the treatment of triple negative breast cancer.
Product Name : PQ203
Product Type : Peptide-drug Conjugate
Upfront Cash : Inapplicable
August 07, 2025
Lead Product(s) : PQ203
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ZW251
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
FDA Clears Zymeworks’ IND For ZW251 GPC3-Targeted ADC
Details : ZW251 is a novel glypican-3 (GPC3)-targeted ADC incorporating topoisomerase 1 inhibitor payload, ZD06519, being investigated for the treatment of HCC.
Product Name : ZW251
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
July 28, 2025
Lead Product(s) : ZW251
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : AMP01
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Amplitude Ventures
Deal Size : $12.0 million
Deal Type : Financing
Reverb Therapeutics Raises $12M To Advance Amplify•R™ Platform
Details : The financing will support Reverb to advance it's lead AMP01 program blocks PD-1 while delivering endogenous IL-15, a key protein that expands and activates cytotoxic T cells.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Undisclosed
February 19, 2025
Lead Product(s) : AMP01
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Amplitude Ventures
Deal Size : $12.0 million
Deal Type : Financing

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Lead Product(s) : Cepharanthine Dihydrochloride,Cepharanthine DiHCl
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
PharmaTher’s Sairiyo Receives Approval to Start Phase 1 Trial of PD-001 (Cepharanthine)
Details : PD-001 (cepharanthine) is an approved, oral, small molecule natural product candidate. It is being evaluated for the treatment of cancer and covid-19 infection.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
August 19, 2024
Lead Product(s) : Cepharanthine Dihydrochloride,Cepharanthine DiHCl
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ZW191
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Zymeworks Announces FDA Clearance of IND for ZW191, Novel Folate Receptor-⍺ ADC
Details : ZW191 is a novel folate receptor-targeted topoisomerase I inhibitor antibody-drug conjugate. Currently, it is being evaluated in the treatment of tumors such as ovarian, endometrial, and lung cancers.
Product Name : Undisclosed
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
July 22, 2024
Lead Product(s) : ZW191
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ZW171
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Zymeworks: FDA Clears IND for ZW171 Bispecific Antibody for Cancers
Details : ZW171 is a novel 2+1 T-cell targeting bispecific antibody for patients with MSLN-expressing cancers, including ovarian cancer, non-small cell lung cancer, mesothelioma, and other cancers.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
June 17, 2024
Lead Product(s) : ZW171
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Bria-Pros+
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
BriaCell Announces Prostate Cancer Candidate Bria-Pros+ and Initiates GMP Manufacturing
Details : Bria-Pros+ is a novel off-the-shelf personalized immunotherapy. It is being evaluated in preclinical studies for the treatment of patients with prostate cancer.
Product Name : Bria-Pros+
Product Type : Undisclosed
Upfront Cash : Inapplicable
February 06, 2024
Lead Product(s) : Bria-Pros+
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : RP-1664
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : RP-1664 demonstrated potent and selective inhibition of PLK4 and synthetic lethality in TRIM37-high tumor cells in preclinical studies. Company expects to initiate clinical trials of RP-1664 in 1H 2024 and RP-3467 in 2H 2024.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
November 15, 2023
Lead Product(s) : RP-1664
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : AccuTOX,Nivolumab,Relatlimab
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Defence’s Succesfull Accutoxtm Pre-Clinical Efficacy Study Complete Ready for Phase I IND Filing
Details : AccuTOX with anti-PD-1 and anti-LAG3 has shown to be very efficient at impeding tumor growth in many animal models including T-cell lymphoma, breast cancer and melanoma.
Product Name : AccuTOX
Product Type : Miscellaneous
Upfront Cash : Inapplicable
May 02, 2023
Lead Product(s) : AccuTOX,Nivolumab,Relatlimab
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
