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    [{"orgOrder":0,"company":"Tyligand Bioscience","sponsor":"Context Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CHINA","productType":"Miscellaneous","year":"2020","type":"Agreement","leadProduct":"Onapristone","moa":"Progesterone receptor","graph1":"Oncology","graph2":"Phase II","graph3":"Tyligand Bioscience","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Tyligand Bioscience \/ Context Therapeutics","highestDevelopmentStatusID":"8","companyTruncated":"Tyligand Bioscience \/ Context Therapeutics"},{"orgOrder":0,"company":"SOLTI Breast Cancer Research Group","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"SPAIN","productType":"Miscellaneous","year":"2019","type":"Inapplicable","leadProduct":"Onapristone","moa":"Progesterone receptor","graph1":"Oncology","graph2":"Phase I","graph3":"SOLTI Breast Cancer Research Group","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"SOLTI Breast Cancer Research Group \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"SOLTI Breast Cancer Research Group \/ Undisclosed"},{"orgOrder":0,"company":"Arno Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2014","type":"Inapplicable","leadProduct":"Onapristone","moa":"Progesterone receptor","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Arno Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Arno Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"Arno Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Arno Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2014","type":"Inapplicable","leadProduct":"Onapristone","moa":"Progesterone receptor","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Arno Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Arno Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"Arno Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Thomas Jefferson University","sponsor":"Context Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2021","type":"Inapplicable","leadProduct":"Onapristone","moa":"Progesterone receptor","graph1":"Oncology","graph2":"Phase II","graph3":"Thomas Jefferson University","amount2":0,"highestDevelopmentShortName":"Ph 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II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet, Extended Release","sponsorNew":"Context Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Context Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Context Therapeutics","sponsor":"Menarini","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2022","type":"Collaboration","leadProduct":"Onapristone","moa":"||Progesterone receptor","graph1":"Oncology","graph2":"Phase II","graph3":"Context Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet, Extended Release","sponsorNew":"Context Therapeutics \/ Menarini","highestDevelopmentStatusID":"8","companyTruncated":"Context Therapeutics \/ Menarini"},{"orgOrder":0,"company":"Context 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Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Miscellaneous","year":"2020","type":"Inapplicable","leadProduct":"Onapristone","moa":"Progesterone receptor","graph1":"Oncology","graph2":"Phase II","graph3":"Context Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Context Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Context Therapeutics \/ Undisclosed"}]

    Find Clinical Drug Pipeline Developments & Deals for Onapristone

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    Onapristone

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                            01

                            Context Therapeutics

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                            Context Therapeutics

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                            Lead Product(s) : Onapristone,Anastrozole

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Context Therapeutics Highlights Clinical Responses from the Phase 2 OATH Clinical Trial Evaluating ONA-XR for ...

                            Details : ONA-XR (onapristone) is a selective progesterone receptor (PR) antagonist designed to block both ligand dependent and ligand-independent activity of PR which downregulates cancer stem cellmobilization, and blocking immune evasion.

                            Product Name : ONA-XR

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            February 06, 2023

                            Lead Product(s) : Onapristone,Anastrozole

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Context Therapeutics

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                            Bio-Europe Autumn
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                            Context Therapeutics

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                            Bio-Europe Autumn
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                            Lead Product(s) : Onapristone,Fulvestrant

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Context Therapeutics® Reports Encouraging Preliminary Phase 2 Data for ONA-XR in Metastatic Breast Cancer

                            Details : ONA-XR (onapristone extended release) is a potent and specific antagonist of the progesterone receptor (PR) that is orally administered. Currently, there are no approved therapies that selectively target PR+ cancers.

                            Product Name : ONA-XR

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 08, 2022

                            Lead Product(s) : Onapristone,Fulvestrant

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Context Therapeutics

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                            Bio-Europe Autumn
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                            Context Therapeutics

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                            Bio-Europe Autumn
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                            Lead Product(s) : Onapristone,Fulvestrant

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Context Therapeutics® Announces Clinical Updates on ONA-XR to be Presented at 2022 San Antonio Breast Cancer ...

                            Details : ONA-XR (onapristone extended release) is a potent and specific antagonist of the progesterone receptor (PR) that is orally administered. Preclinical and clinical data suggest that ONA-XR has anticancer activity by inhibiting progesterone receptor binding...

                            Product Name : ONA-XR

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            November 21, 2022

                            Lead Product(s) : Onapristone,Fulvestrant

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Context Therapeutics

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                            Bio-Europe Autumn
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                            Context Therapeutics

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                            Bio-Europe Autumn
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                            Lead Product(s) : Onapristone,Letrozole,Palbociclib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Menarini

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Context Therapeutics and The Menarini Group Announce Clinical Trial Collaboration and Supply Agreement to Eval...

                            Details : ONA-XR (onapristone extended release) is a potent and specific antagonist of the progesterone receptor (PR) that is orally administered. ONA-XR is an investigational drug that has not been approved for marketing by any regulatory authority.

                            Product Name : ONA-XR

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            August 02, 2022

                            Lead Product(s) : Onapristone,Letrozole,Palbociclib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Menarini

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            05

                            Context Therapeutics

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                            Bio-Europe Autumn
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                            Context Therapeutics

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                            Bio-Europe Autumn
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                            Lead Product(s) : Onapristone,Anastrozole

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Context Therapeutics Announces Poster Presentation at the Upcoming 2022 ASCO Annual Meeting

                            Details : Lead clinical-stage oral progesterone receptor (PR) antagonist ONA-XR (onapristone extended release) demonstrates monotherapy clinical activity in advanced granulosa cell tumor of the ovary.

                            Product Name : ONA-XR

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 05, 2022

                            Lead Product(s) : Onapristone,Anastrozole

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Context Therapeutics

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                            Bio-Europe Autumn
                            Not Confirmed

                            Context Therapeutics

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                            Bio-Europe Autumn
                            Not Confirmed
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                            Lead Product(s) : Onapristone

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Context Therapeutics Announces Encouraging Preclinical Data from Two Programs to be Presented at the American ...

                            Details : ONA-XR is a novel, first-in-class small molecule under development as a potent and specific antagonist of PR, a key unchecked mechanism in hormone-driven women’s cancers.The preclinical data for onapristone (ONA-XR) support it as a potent progesterone ...

                            Product Name : ONA-XR

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            April 11, 2022

                            Lead Product(s) : Onapristone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Context Therapeutics

                            U.S.A arrow
                            Bio-Europe Autumn
                            Not Confirmed

                            Context Therapeutics

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                            Bio-Europe Autumn
                            Not Confirmed
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                            Lead Product(s) : Onapristone

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Context Therapeutics® Announces Acceptance of Five Abstracts to be Presented at the American Association for ...

                            Details : ONA-XR (onapristone extended release), a potent, specific progesterone receptor (PR) antagonist being evaluated for PR+ breast, ovarian and endometrial cancer, and our preclinical anti-claudin 6 (CLDN6) bispecific monoclonal antibody (BsMAb) for gynecolo...

                            Product Name : ONA-XR

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            March 08, 2022

                            Lead Product(s) : Onapristone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Context Therapeutics

                            U.S.A arrow
                            Bio-Europe Autumn
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                            Context Therapeutics

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                            Bio-Europe Autumn
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                            Lead Product(s) : Onapristone

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Context Therapeutics Announces Positive Data from ONA-XR in Early Breast Cancer at 2021 San Antonio Breast Can...

                            Details : Data demonstrated ONA-XR (Onapristone extended release) decreased proliferation in tumors with high PR+ at baseline in early breast cancer.

                            Product Name : ONA-XR

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 09, 2021

                            Lead Product(s) : Onapristone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            University of Wisconsin, Madison

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                            Bio-Europe Autumn
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                            University of Wisconsin, Madison

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                            Bio-Europe Autumn
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                            Lead Product(s) : Onapristone

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Context Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Onapristone and Fulvestrant for ER+ HER2- Metastatic Breast Cancer After Endocrine Therapy and CDK4/6 Inhibito...

                            Details : Onapristone is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Breast Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            February 04, 2021

                            Lead Product(s) : Onapristone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Context Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Thomas Jefferson University

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                            Bio-Europe Autumn
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                            Thomas Jefferson University

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                            Bio-Europe Autumn
                            Not Confirmed
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                            Lead Product(s) : Onapristone

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Context Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Onapristone and Anastrozole for the Treatment of Refractory Hormone Receptor Positive Endometrial Cancer

                            Details : Onapristone is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Endometrial Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            January 22, 2021

                            Lead Product(s) : Onapristone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Context Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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