
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : Palazestrant
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : TD Cowen | Evercore ISI | Guggenheim Securities | LifeSci Capital
Deal Size : $218.5 million
Deal Type : Public Offering
Olema Oncology Closes $218.5M Public Offering, Underwriters' Option Fully Exercised
Details : In the public offering, Palazestrant, a miscellaneous product targeting estrogen receptor, aims to advance breast cancer treatment.
Product Name : OP-1250
Product Type : Miscellaneous
Upfront Cash : Undisclosed
November 20, 2025
Lead Product(s) : Palazestrant
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : TD Cowen | Evercore ISI | Guggenheim Securities | LifeSci Capital
Deal Size : $218.5 million
Deal Type : Public Offering

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Lead Product(s) : Palazestrant
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : TD Cowen | Evercore ISI | Guggenheim Securities | LifeSci Capital
Deal Size : $190.0 million
Deal Type : Public Offering
Olema Oncology Prices $190.0M Public Offering of Common Stock
Details : In the public offering, Palazestrant, a miscellaneous product targeting estrogen receptor, aims to advance breast cancer treatment.
Product Name : OP-1250
Product Type : Miscellaneous
Upfront Cash : Undisclosed
November 19, 2025
Lead Product(s) : Palazestrant
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : TD Cowen | Evercore ISI | Guggenheim Securities | LifeSci Capital
Deal Size : $190.0 million
Deal Type : Public Offering

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Lead Product(s) : Palazestrant,Atirmociclib
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Pfizer Inc
Deal Size : Undisclosed
Deal Type : Collaboration
Olema Oncology Announces New Clinical Trial Agreement with Pfizer
Details : The companies will evaluate in a Phase 1b/2 study the safety and combinability of OP-1250 (palazestrant) plus PF-07220060 (atirmociclib), in metastatic breast cancer.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
September 02, 2025
Lead Product(s) : Palazestrant,Atirmociclib
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Pfizer Inc
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : Palazestrant
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Novartis Pharmaceuticals Corporation
Deal Size : Inapplicable
Deal Type : Inapplicable
Palazestrant with Ribociclib as First-line Treatment in ER+/HER2- Advanced Breast Cancer
Details : Palazestrant is a Other Small Molecule drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Breast Neoplasms.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
July 25, 2025
Lead Product(s) : Palazestrant
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Novartis Pharmaceuticals Corporation
Deal Size : Inapplicable
Deal Type : Inapplicable

Study of OP-3136 in Advanced or Metastatic Solid Tumors
Details : OP-3136 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Breast Neoplasms.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
January 20, 2025

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Lead Product(s) : OP-3136
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Olema Oncology Receives FDA IND Clearance for OP-3136 KAT6 Inhibitor
Details : OP-3136 is an orally bioavailable, potent KAT6A/B-selective inhibitor. It is discovered and selected as a lead candidate for the treatment of breast cancer.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
December 09, 2024
Lead Product(s) : OP-3136
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Palazestrant,Ribociclib
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Adage Capital Partners
Deal Size : $250.0 million
Deal Type : Private Placement
Olema & Novartis Collaborate on Breast Cancer Trials, Raise $250M Equity Placement
Details : The net proceeds will be used to fund the clinical development of company's lead product OP-1250 (palazestrant), which is being evaluated for the treatment of ER+/HER2-metastatic breast cancer.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
December 02, 2024
Lead Product(s) : Palazestrant,Ribociclib
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Adage Capital Partners
Deal Size : $250.0 million
Deal Type : Private Placement

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Lead Product(s) : Palazestrant,Ribociclib
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Novartis Pharmaceuticals Corporation
Deal Size : Undisclosed
Deal Type : Collaboration
Olema & Novartis Collaborate on Breast Cancer Trials, Raise $250M Equity Placement
Details : Through collaboration, Novartis will provide Olema with ribociclib for the planned late-stage OP-1250 (palazestrant) trial with ribociclib in ER+/HER2-metastatic breast cancer.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
December 02, 2024
Lead Product(s) : Palazestrant,Ribociclib
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Novartis Pharmaceuticals Corporation
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : OP-3136
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Aurigene
Deal Size : Inapplicable
Deal Type : Inapplicable
Olema Nominates OP-3136, an Orally Bioavailable KAT6 Inhibitor, as Development Candidate
Details : OP-3136 is an orally bioavailable, potent KAT6A/B-selective inhibitor. It is discovered and selected as a lead candidate for the treatment of breast cancer.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
January 08, 2024
Lead Product(s) : OP-3136
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Aurigene
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Palazestrant,Ribociclib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Novartis Pharmaceuticals Corporation
Deal Size : Undisclosed
Deal Type : Expanded Collaboration
Olema Oncology Announces Expansion of Collaboration Agreement with Novartis
Details : Under the collaboration, Novartis will increase the size of the ongoing Phase 1/2 study testing OP-1250 (palazestrant), an orally-available small molecule with dual activity as both a complete ER antagonist and a selective ER degrader, in combination wit...
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
October 10, 2023
Lead Product(s) : Palazestrant,Ribociclib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Novartis Pharmaceuticals Corporation
Deal Size : Undisclosed
Deal Type : Expanded Collaboration
