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              Odonate Therapeutics

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              Positive Results of CONTESSA Presented at the 2020 San Antonio Breast Cancer Symposium (SABCS)

              Details:

              CONTESSA is a multinational, multicenter, randomized, Phase 3 study of tesetaxel, an investigational, orally administered taxane, in patients with MBC. CONTESSA met the primary endpoint of improved PFS as assessed by the IRC.

              Lead Product(s): Tesetaxel,Capecitabine

              Therapeutic Area: Oncology Product Name: Undisclosed

              Highest Development Status: Phase III Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable December 11, 2020

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              Odonate Therapeutics

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              Odonate Therapeutics Initiates Cohort 3 of CONTESSA TRIO to Evaluate Tesetaxel Monotherapy in Patients with Metastatic Breast Cancer

              Details:

              Cohorts 2 and 3 of CONTESSA TRIO will expand on results from TOB203, a Phase 2 study that evaluated tesetaxel monotherapy in 38 patients with hormone receptor-positive, HER2-negative MBC.

              Lead Product(s): Tesetaxel

              Therapeutic Area: Oncology Product Name: Undisclosed

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable December 07, 2020

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              Odonate Therapeutics

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              Odonate Therapeutics Results of CONTESSA in the Treatment of Patients with Metastatic Breast Cancer, to Be Presented at the 2020 SABCS

              Details:

              CONTESSA is comparing tesetaxel dosed orally at 27 mg/m2 got each each 21-day cycle plus a reduced dose of capecitabine to the approved dose of capecitabine alone in patients with HER2 (-), HR (+) MBC previously treated with a taxane in the neoadjuvant or adjuvant setting.

              Lead Product(s): Tesetaxel,Capecitabine

              Therapeutic Area: Oncology Product Name: Undisclosed

              Highest Development Status: Phase III Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable October 05, 2020

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              Odonate Therapeutics

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              Odonate Therapeutics Announces Public Offering of Shares of Common Stock

              Details:

              Odonate intends to use the proceeds from the proposed underwritten public offering of its shares of common stock for development, regulatory and commercial preparation activities relating to tesetaxel, as well as for working capital and general corporate purposes.

              Lead Product(s): Tesetaxel,Capecitabine

              Therapeutic Area: Oncology Product Name: Undisclosed

              Highest Development Status: Phase III Product Type: Small molecule

              Partner/Sponsor/Collaborator: Jefferies

              Deal Size: $80.0 million Upfront Cash: Undisclosed

              Deal Type: Public Offering August 27, 2020

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              Odonate Therapeutics

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              Odonate Therapeutics Announces Positive Top-line Results from CONTESSA

              Details:

              CONTESSA met the primary endpoint of improved PFS as assessed by the IRC. Median PFS was 9.8 months for tesetaxel plus a reduced dose of capecitabine versus 6.9 months for the approved dose of capecitabine alone, an improvement of 2.9 months.

              Lead Product(s): Tesetaxel,Capecitabine

              Therapeutic Area: Oncology Product Name: Undisclosed

              Highest Development Status: Phase III Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable August 24, 2020

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