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Pharma","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Miscellaneous","year":"2022","type":"Inapplicable","leadProduct":"APX3330","moa":"DNA-(apurinic or apyrimidinic site) lyase","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Ocuphire Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Ocuphire Pharma \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Ocuphire Pharma \/ Undisclosed"},{"orgOrder":0,"company":"Ocuphire Pharma","sponsor":"Opus Genetics","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Merger","leadProduct":"APX3330","moa":"DNA-(apurinic or apyrimidinic site) lyase","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Ocuphire Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Ocuphire Pharma \/ Ocuphire Pharma","highestDevelopmentStatusID":"8","companyTruncated":"Ocuphire Pharma \/ Ocuphire Pharma"},{"orgOrder":0,"company":"Ocuphire Pharma","sponsor":"Visiox Pharma","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Merger","leadProduct":"Omidenepag Isopropyl","moa":"Prostanoid EP2 receptor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"Ocuphire Pharma","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Solution","sponsorNew":"Ocuphire Pharma \/ Ocuphire Pharma","highestDevelopmentStatusID":"15","companyTruncated":"Ocuphire Pharma \/ Ocuphire Pharma"}]

Find Clinical Drug Pipeline Developments & Deals by Ocuphire Pharma

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Phentolamine is a Other Small Molecule drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Night Blindness.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          August 26, 2025

                          Lead Product(s) : Phentolamine Mesylate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : The acquisition creates a leading, clinical-stage company focused on developing gene therapies, including APX3330, an oral small-molecule inhibitor of Ref-1 for non-proliferative diabetic retinopathy.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          October 22, 2024

                          Lead Product(s) : APX3330

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Recipient : Opus Genetics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          03

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Nyxol (phentolamine ophthalmic solution) is an adrenergic receptor antagonist. It is being evaluated for the treatment Presbyopia.

                          Product Name : Nyxol

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 05, 2024

                          Lead Product(s) : Phentolamine Mesylate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Through the merger, Ocuvex will boast a robust pipeline of ophthalmic medicines, which includes Omlonti (omidenepag isopropyl), indicated for the treatment of open-angle glaucoma.

                          Product Name : Omlonti

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          August 19, 2024

                          Lead Product(s) : Omidenepag Isopropyl

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved FDF

                          Recipient : Visiox Pharma

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          05

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Phentolamine is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Presbyopia.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          August 07, 2024

                          Lead Product(s) : Phentolamine Mesylate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Nyxol (phentolamine mesylate ophthalmic solution) is an alpha1/2 adrenergic receptor inhibitor being investigated in Phase 3 for decreased visual acuity under low light after keratorefractive surgery.

                          Product Name : Nyxol

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          April 11, 2024

                          Lead Product(s) : Phentolamine Mesylate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Phentolamine is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Night Blindness.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          April 05, 2024

                          Lead Product(s) : Phentolamine Mesylate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Viatris

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Nyxol (phentolamine ophthalmic solution) is anadrenergic receptor antagonist. It is being evaluated in phase 3 clinical trials for decreased visual acuity under dim (mesopic) light conditions.

                          Product Name : Nyxol

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          January 04, 2024

                          Lead Product(s) : Phentolamine Mesylate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Ryzumvi (phentolamine ophthalmic solution) 0.75% is a preservative-free ophthalmic solution and a nonselective alpha adrenergic antagonist, which is investigated for Pharmacologically-Induced Mydriasis Produced by Adrenergic Agonists.

                          Product Name : Nyxol

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 27, 2023

                          Lead Product(s) : Phentolamine Mesylate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved FDF

                          Sponsor : Viatris

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : Nyxol® is a preservative-free ophthalmic solution containing 0.75% phentolamine (or 1% phentolamine mesylate), a nonselective alpha adrenergic antagonist that inhibits the contraction of smooth muscle of the iris.

                          Product Name : Nyxol

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          February 13, 2023

                          Lead Product(s) : Phentolamine Mesylate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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