
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : Mazindol
Therapeutic Area : Psychiatry/Psychology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
NLS Shows Mazindol Reduces Fentanyl Reward in Preclinical Study
Details : Quilience (mazindol) is a MAO transporter inhibitor which may offer a novel, non-opioid approach for the treatment of fentanyl use disorder.
Product Name : Undisclosed
Product Type : Controlled Substance
Upfront Cash : Inapplicable
April 15, 2025
Lead Product(s) : Mazindol
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : AEX-2
Therapeutic Area : Sleep
Study Phase : Preclinical
Sponsor : Aexon Labs
Deal Size : Inapplicable
Deal Type : Inapplicable
NLS Announces Preclinical Data for AEX-2 Dual Orexin Agonist
Details : AEX-2 is a potential first-in-class non-sulfonamide dual orexin receptor agonist (DOXA), which is being evaluated for narcolepsy and related neurological disorders.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
February 27, 2025
Lead Product(s) : AEX-2
Therapeutic Area : Sleep
Highest Development Status : Preclinical
Sponsor : Aexon Labs
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Mazindol
Therapeutic Area : Psychiatry/Psychology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
NLS Starts Preclinical Program for Mazindol ER in Fentanyl Dependence
Details : Quilience®, is a proprietary extended-release formulation of Mazindol a 5-HT1A receptor modulator, is being developed for the treatment of fentanyl dependence.
Product Name : Quilience
Product Type : Controlled Substance
Upfront Cash : Inapplicable
January 28, 2025
Lead Product(s) : Mazindol
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : AEX-41
Therapeutic Area : Sleep
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
NLS Reports Preclinical Data for Dual Orexin Agonists in Narcolepsy Treatment
Details : AEX-41 is a first-in-class non-sulfonamide DOXAs, are designed to target both OX1R/OX2R while inhibiting cathepsins, which play significant role in narcolepsy and other neurological disorders.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
December 03, 2024
Lead Product(s) : AEX-41
Therapeutic Area : Sleep
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : AEX-41
Therapeutic Area : Sleep
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
NLS Showcases Preclinical Non-Sulfonamide Dual Orexin Agonists for Narcolepsy
Details : AEX-41 and AEX-2, two first-in-class non-sulfonamide DOXAs, are designed to target both OX1R and OX2R to address the unmet needs in narcolepsy and related neurological disorders.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
November 18, 2024
Lead Product(s) : AEX-41
Therapeutic Area : Sleep
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : AEX-2
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
NLS Pharmaceutics Reports Preclinical Results for Parkinson's Disease Treatments
Details : AEX-23, which targets OX1R and shows promise in modulating the effects of α-synuclein on neurons. Currently, it is being evaluated in the early-stage clinical trial studies for Parkinson's disease.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
June 27, 2024
Lead Product(s) : AEX-2
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Mazindol
Therapeutic Area : Sleep
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
NLS Pharmaceutics Reports Positive KO-874 Study on Mazindol for Narcoleptic-like Model
Details : The Company's lead candidate, Quilience®, is a proprietary extended-release formulation of Mazindol (Mazindol ER) and is being developed for the treatment of orexin-B-saporin induced narcolepsy.
Product Name : Quilience
Product Type : Controlled Substance
Upfront Cash : Inapplicable
May 28, 2024
Lead Product(s) : Mazindol
Therapeutic Area : Sleep
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : AEX-2
Therapeutic Area : Sleep
Study Phase : Preclinical
Recipient : Aexon Labs
Deal Size : Undisclosed
Deal Type : Licensing Agreement
NLS Pharmaceutics Secures Exclusive Global License for Dual Orexin Agonist Platform
Details : The agreement grants NLS global rights to next-gen oral OX1R/OX2R agonists, including AEX-2, tailored for narcolepsy, idiopathic hypersomnia, Parkinson's disease, dementia with Lewy bodies.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
March 20, 2024
Lead Product(s) : AEX-2
Therapeutic Area : Sleep
Highest Development Status : Preclinical
Recipient : Aexon Labs
Deal Size : Undisclosed
Deal Type : Licensing Agreement

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Lead Product(s) : Undisclosed
Therapeutic Area : Sleep
Study Phase : Preclinical
Sponsor : Aexon Labs
Deal Size : Undisclosed
Deal Type : Agreement
Details : Under the agreement, NLS may acquire development and commercialization rights to Aexon Labs' dual orexin receptor agonists platform for the treatment of narcolepsy and idiopathic hypersomnia, as well as neuro-degenerative disorders.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
December 01, 2023
Lead Product(s) : Undisclosed
Therapeutic Area : Sleep
Highest Development Status : Preclinical
Sponsor : Aexon Labs
Deal Size : Undisclosed
Deal Type : Agreement

Details : NLS-2 (mazindol ER) is a triple monoamine reuptake inhibitor and partial Orexin-2 receptor agonist. It is being developed for the treatment of narcolepsy, and potentially other sleep-wake disorders.
Product Name : Quilience
Product Type : Controlled Substance
Upfront Cash : Inapplicable
July 03, 2023
