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II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Nippon Shinyaku \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Nippon Shinyaku \/ Inapplicable"},{"orgOrder":0,"company":"Nippon Shinyaku","sponsor":"NS Pharma","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Oligonucleotide","year":"2023","type":"Inapplicable","leadProduct":"NS-089","moa":"Undisclosed","graph1":"Genetic Disease","graph2":"Phase II","graph3":"Nippon Shinyaku","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Nippon Shinyaku \/ Nippon Shinyaku","highestDevelopmentStatusID":"8","companyTruncated":"Nippon Shinyaku \/ Nippon Shinyaku"},{"orgOrder":0,"company":"NS Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Cell and Gene therapy","year":"2024","type":"Inapplicable","leadProduct":"NS-050\/NCNP-03","moa":"Undisclosed","graph1":"Genetic Disease","graph2":"Phase I\/ Phase II","graph3":"NS Pharma","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"NS Pharma \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"NS Pharma \/ Inapplicable"},{"orgOrder":0,"company":"Nippon Shinyaku","sponsor":"NS Pharma","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Undisclosed","year":"2023","type":"Inapplicable","leadProduct":"NS-050","moa":"Undisclosed","graph1":"Genetic Disease","graph2":"Phase I\/ Phase II","graph3":"Nippon Shinyaku","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Nippon Shinyaku \/ Nippon Shinyaku","highestDevelopmentStatusID":"7","companyTruncated":"Nippon Shinyaku \/ Nippon Shinyaku"},{"orgOrder":0,"company":"NS Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Cell and Gene therapy","year":"2023","type":"Inapplicable","leadProduct":"NS-050\/NCNP-03","moa":"Undisclosed","graph1":"Genetic Disease","graph2":"Phase I\/ Phase II","graph3":"NS Pharma","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"NS Pharma \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"NS Pharma \/ Inapplicable"},{"orgOrder":0,"company":"Nippon Shinyaku","sponsor":"Mina Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Rare Diseases and Disorders","country":"UNITED KINGDOM","productType":"Undisclosed","year":"2024","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Rare Diseases and Disorders","graph2":"Discovery Platform","graph3":"Nippon Shinyaku","amount2":0,"highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Rare Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Nippon Shinyaku \/ Nippon Shinyaku","highestDevelopmentStatusID":"3","companyTruncated":"Nippon Shinyaku \/ Nippon Shinyaku"}]

Find Clinical Drug Pipeline Developments & Deals by Nippon Shinyaku

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                          Top Deals by Deal Size (USD bn)

                          01

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
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                          Details : NS-229 is being investigated as a selective Janus kinase 1 (JAK1) inhibitor to help regulate immune cell function and prevent the immune system from causing tissue damage.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 21, 2025

                          Lead Product(s) : NS-229

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          ChemOutsourcing
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                          ChemOutsourcing
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                          Details : CAP-1002 (deramiocel) consists of allogeneic cardiosphere-derived cells (CDCs). It is under late stage clinical development for the treatment of Duchenne muscular dystrophy.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          March 10, 2025

                          Lead Product(s) : Deramiocel

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Recipient : Capricor Therapeutics

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
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                          Details : Under the licensing agreement, Nippon received an option to acquire exclusive U.S. rights to commercialize r-hIL-18BP (tadekinig alfa) to treat NLRC4-MAS.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : $6.0 million

                          January 27, 2025

                          Lead Product(s) : Tadekinig Alpha

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Recipient : AB2 Bio

                          Deal Size : $686.0 million

                          Deal Type : Licensing Agreement

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                          04

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
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                          Details : The partnership aims to advance the clinical development of RGX-121, a potential one-time AAV therapeutic for the treatment of Mucopolysaccharidosis II (MPS II), also known as Hunter syndrome.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : $110.0 million

                          January 14, 2025

                          Lead Product(s) : RGX-121

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase II/ Phase III

                          Recipient : Regenxbio

                          Deal Size : $810.0 million

                          Deal Type : Partnership

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                          05

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
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                          Details : Nippon Shinyaku will receive exclusive commercial rights of ATSN-101, a first-in-class, investigational gene therapy for the treatment of LCA1, in the U.S. and Japan.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          November 13, 2024

                          Lead Product(s) : ATSN-101

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase I/ Phase II

                          Recipient : Atsena Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          06

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
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                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Radiolabeled Compounds

                          Upfront Cash : Inapplicable

                          November 01, 2024

                          Lead Product(s) : 14-C NS-580

                          Therapeutic Area : Undisclosed

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
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                          Details : NS-050/NCNP-03 is an antisense oligonucleotide and is being developed for the treatment of Duchenne muscular dystrophy (Duchenne).

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          October 09, 2024

                          Lead Product(s) : NS-050/NCNP-03

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
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                          Details : Through the partnership, Nippon Shinyaku will commercialize and distribute Capricor’s lead asset, CAP-1002 (deramiocel), to treat Duchenne muscular dystrophy in Europe.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : $35.0 million

                          September 17, 2024

                          Lead Product(s) : Deramiocel

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Recipient : Capricor Therapeutics

                          Deal Size : $735.0 million

                          Deal Type : Partnership

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                          09

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Viltepso (viltolarsen), an antisense oligonucleotide, is being investigated in ambulatory boys with Duchenne muscular dystrophy.

                          Product Name : Viltepso

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          May 27, 2024

                          Lead Product(s) : Viltolarsen

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : MiNA Therapeutics will use its RNAa algorithm and platform to identify RNAa molecules targeting rare CNS genetic diseases under the collaboration.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          April 04, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Discovery Platform

                          Recipient : Mina Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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