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Molecule","year":"2025","type":"Collaboration","leadProduct":"HT-ALZ","moa":"NK-1 receptor","graph1":"Neurology","graph2":"Preclinical","graph3":"Hoth Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral Film","sponsorNew":"Hoth Therapeutics \/ Washington University School of Medicine","highestDevelopmentStatusID":"4","companyTruncated":"Hoth Therapeutics \/ Washington University School of Medicine"},{"orgOrder":0,"company":"Mira Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Ketamine Analog","moa":"Undisclosed","graph1":"Neurology","graph2":"Preclinical","graph3":"Mira Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Mira Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Mira Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Capsida","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"CAP-003","moa":"GCase","graph1":"Neurology","graph2":"Preclinical","graph3":"Capsida","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Capsida \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Capsida \/ Inapplicable"},{"orgOrder":0,"company":"Scribe Therapeutics","sponsor":"Prevail Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Neurology","graph2":"Preclinical","graph3":"Scribe Therapeutics","amount2":1.5800000000000001,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":1.5800000000000001,"dosageForm":"Undisclosed","sponsorNew":"Scribe Therapeutics \/ Prevail Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"Scribe Therapeutics \/ Prevail Therapeutics"},{"orgOrder":0,"company":"Hoth Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"HT-ALZ","moa":"NK-1 receptor","graph1":"Neurology","graph2":"Preclinical","graph3":"Hoth Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral Film","sponsorNew":"Hoth Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Hoth Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Sangamo Therapeutics","sponsor":"Eli Lilly","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Licensing Agreement","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Neurology","graph2":"Preclinical","graph3":"Sangamo Therapeutics","amount2":1.4199999999999999,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":1.4199999999999999,"dosageForm":"Intravenous","sponsorNew":"Sangamo Therapeutics \/ Eli Lilly","highestDevelopmentStatusID":"4","companyTruncated":"Sangamo Therapeutics \/ Eli Lilly"},{"orgOrder":0,"company":"Channel Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"CT2000","moa":"NaV1.7 channel","graph1":"Neurology","graph2":"Preclinical","graph3":"Channel Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Ophthalmic Solution","sponsorNew":"Channel Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Channel Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"City Therapeutics","sponsor":"Biogen","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Oligonucleotide","year":"2025","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Neurology","graph2":"Preclinical","graph3":"City Therapeutics","amount2":0.050000000000000003,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0.050000000000000003,"dosageForm":"Undisclosed","sponsorNew":"City Therapeutics \/ Biogen","highestDevelopmentStatusID":"4","companyTruncated":"City Therapeutics \/ Biogen"},{"orgOrder":0,"company":"Hesperos","sponsor":"Psilera","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Collaboration","leadProduct":"PSIL-006","moa":"5-HT2A receptor","graph1":"Neurology","graph2":"Preclinical","graph3":"Hesperos","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Hesperos \/ Psilera","highestDevelopmentStatusID":"4","companyTruncated":"Hesperos \/ Psilera"}]

    Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                            01

                            Cayman Chemical Company Inc

                            U.S.A
                            IFT FIRST
                            Not Confirmed
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : SBIR

                            Deal Size : Undisclosed

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Cayman Receives SBIR Grant for Alzheimer’s Research

                            Details : The funding will be used to develop an assay platform and novel antibodies to support the treatment, prevention, and early diagnosis of Alzheimer’s disease and other tauopathies.

                            Product Name : Undisclosed

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            August 10, 2020

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : SBIR

                            Deal Size : Undisclosed

                            Deal Type : Funding

                            Cayman

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                            02

                            Hesperos

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed

                            Hesperos

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed
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                            Lead Product(s) : PSIL-006

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Psilera

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Psilera Collaborates with Drug Development Leader Hesperos to Advance PSIL-006

                            Details : The collaboration aims to accelerate the preclinical development of Psilera's lead compound, PSIL-006, targeting frontotemporal dementia (FTD).

                            Product Name : PSIL-006

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            June 09, 2025

                            Lead Product(s) : PSIL-006

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Psilera

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            03

                            City Therapeutics

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed

                            City Therapeutics

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Biogen

                            Deal Size : $1,046.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Biogen and City Therapeutics Partner On RNAi-Based Therapy Development

                            Details : Through the collaboration, City will leverage its next-generation RNAi engineering technologies to develop an RNAi trigger molecule combined with proprietary drug delivery technology from Biogen.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : $16.0 million

                            May 27, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Biogen

                            Deal Size : $1,046.0 million

                            Deal Type : Collaboration

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                            04

                            Scribe Therapeutics

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed

                            Scribe Therapeutics

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Prevail Therapeutics

                            Deal Size : $1575.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Scribe Hits Milestone with Prevail, Will Present AAV Tech at ASGCT

                            Details : Scribe and Prevail’s collaboration will advance in vivo therapeutics for neurological and neuromuscular diseases using Scribe’s CRISPR technology.

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : $75.0 million

                            April 28, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Prevail Therapeutics

                            Deal Size : $1575.0 million

                            Deal Type : Collaboration

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                            05

                            Capsida

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed

                            Capsida

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed
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                            Lead Product(s) : CAP-003

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Capsida Presents Best-in-Class CAP-003 Data in Parkinson’s Disease with GBA Mutations

                            Details : CAP-003, enabled by one of Capsida's proprietary engineered capsids and cargo, demonstrates best-in-class potential to effectively and safely treat parkinson's disease associated with GBA mutations.

                            Product Name : CAP-003

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            April 03, 2025

                            Lead Product(s) : CAP-003

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Hoth Therapeutics

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed

                            Hoth Therapeutics

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed
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                            Lead Product(s) : HT-ALZ

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Washington University School of Medicine

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Hoth, WashU Advance Alzheimer's Program with NK-1 Antagonist HT-ALZ

                            Details : The collaboration aims to advance the clinical development of HT-ALZ, which is being evaluated for the treatment of Alzheimer's disease.

                            Product Name : HT-ALZ

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            April 02, 2025

                            Lead Product(s) : HT-ALZ

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Washington University School of Medicine

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            07

                            Hoth Therapeutics

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed

                            Hoth Therapeutics

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed
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                            Lead Product(s) : HT-ALZ

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Hoth Shows HT-ALZ Reduced Brain Aβ by ~15% in Alzheimer’s Preclinical Study

                            Details : HT-ALZ, a proprietary formulation of an FDA-approved NK-1 receptor antagonist, has shown significant cognitive and behavioral benefits in APP/PS1 mouse models of Alzheimer's disease.

                            Product Name : HT-ALZ

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 02, 2025

                            Lead Product(s) : HT-ALZ

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            NeuroNOS

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed

                            NeuroNOS

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : $2.0 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            NeuroNOS Secures $2M Funding to Advance Innovative Autism Therapy

                            Details : The funding will accelerate the preclinical development of NeuroNOS’s small-molecule drug, designed as an injectable or oral treatment for children with autism.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            March 24, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : $2.0 million

                            Deal Type : Funding

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                            09

                            Virpax Pharmaceuticals

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed

                            Virpax Pharmaceuticals

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed
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                            Lead Product(s) : Bupivacaine

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Virpax Moves Probudur Dose Study to IND Stage

                            Details : Probudur (bupivacaine) is a sodium channel alpha subunit blocker, small molecule drug candidate, which is currently being evaluated for the treatment of post-operative pain.

                            Product Name : Probudur

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 18, 2025

                            Lead Product(s) : Bupivacaine

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Myrobalan Therapeutics

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed

                            Myrobalan Therapeutics

                            U.S.A arrow
                            IFT FIRST
                            Not Confirmed
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                            Lead Product(s) : MRO-002

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : National Multiple Sclerosis Society

                            Deal Size : $0.8 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Myrobalan Wins Grant to Advance MRO-002 in Multiple Sclerosis Treatment

                            Details : The funding aims to support the MRO-002 is an orally bioavailable, brain-penetrant, small molecule antagonist of GPR17. It is being evaluated for progressive multiple sclerosis.

                            Product Name : MRO-002

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            March 13, 2025

                            Lead Product(s) : MRO-002

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : National Multiple Sclerosis Society

                            Deal Size : $0.8 million

                            Deal Type : Funding

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