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    [{"orgOrder":0,"company":"Uniqure","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"NETHERLANDS","productType":"Cell and Gene therapy","year":"2022","type":"Inapplicable","leadProduct":"AMT\u2011240","moa":"AOPE","graph1":"Neurology","graph2":"Preclinical","graph3":"Uniqure","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Uniqure \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Uniqure \/ Inapplicable"},{"orgOrder":0,"company":"VectorY","sponsor":"Annogen","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"NETHERLANDS","productType":"Undisclosed","year":"2023","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Neurology","graph2":"Preclinical","graph3":"VectorY","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral","sponsorNew":"VectorY \/ Annogen","highestDevelopmentStatusID":"4","companyTruncated":"VectorY \/ Annogen"},{"orgOrder":0,"company":"Intravacc","sponsor":"European Union","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"NETHERLANDS","productType":"Undisclosed","year":"2022","type":"Funding","leadProduct":"Undisclosed","moa":"Polyglycine alanine","graph1":"Neurology","graph2":"Preclinical","graph3":"Intravacc","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Intravacc \/ European Union","highestDevelopmentStatusID":"4","companyTruncated":"Intravacc \/ European Union"},{"orgOrder":0,"company":"VectorY","sponsor":"Forbion","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"NETHERLANDS","productType":"Antibody","year":"2021","type":"Financing","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Neurology","graph2":"Preclinical","graph3":"VectorY","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral","sponsorNew":"VectorY \/ Forbion","highestDevelopmentStatusID":"4","companyTruncated":"VectorY \/ Forbion"},{"orgOrder":0,"company":"VectorY","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"NETHERLANDS","productType":"Cell and Gene therapy","year":"2022","type":"Inapplicable","leadProduct":"AAV-VecTabs","moa":"Undisclosed","graph1":"Neurology","graph2":"Preclinical","graph3":"VectorY","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"VectorY \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"VectorY \/ Inapplicable"},{"orgOrder":0,"company":"Uniqure","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"NETHERLANDS","productType":"Undisclosed","year":"2022","type":"Inapplicable","leadProduct":"AMT-210","moa":"Undisclosed","graph1":"Neurology","graph2":"Preclinical","graph3":"Uniqure","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Uniqure \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Uniqure \/ Inapplicable"}]

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                            01

                            VectorY

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                            VectorY

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                            Lead Product(s) : VTx-002

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : University Medical Center

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            UMC Utrecht and VectorY collaborate to identify biomarkers of ALS in new study

                            Details : The collaboration aims to support VectorY’s lead program, VTx-002, which is being evaluated in the early-stage clinical trial studies for the treatment of ALS.

                            Product Name : VTx-002

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            June 18, 2024

                            Lead Product(s) : VTx-002

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : University Medical Center

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            02

                            VectorY

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                            VectorY

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                            Lead Product(s) : VTx-002

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : UMC Utrecht

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            UMC Utrecht and VectorY Therapeutics collaborate in ALS Biomarker Study

                            Details : VTx-002, a vectorized antibody that selectively clears misfolded and aggregated TDP-43 from the cytoplasm of neuronal cells, is being developed for the treatment of Amyotrophic Lateral Sclerosis.

                            Product Name : VTx-002

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            June 17, 2024

                            Lead Product(s) : VTx-002

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : UMC Utrecht

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            03

                            Kynexis Therapeutics

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                            Kynexis Therapeutics

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                            Lead Product(s) : KYN-5356

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Forbion

                            Deal Size : $62.1 million

                            Deal Type : Series A Financing

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                            Kynexis Launched to Advance Precision Therapeutics for Brain Diseases

                            Details : Through the proceeds, Kynexis will advance its lead therapeutic candidate, KYN-5356, a potential first-in-class KAT-II inhibitor for the treatment of cognitive impairment associated with schizophrenia (CIAS), toward clinical development.

                            Product Name : KYN-5356

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            July 11, 2023

                            Lead Product(s) : KYN-5356

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Forbion

                            Deal Size : $62.1 million

                            Deal Type : Series A Financing

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                            04

                            Uniqure

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                            Uniqure

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                            Lead Product(s) : AMT‑240

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            uniQure Announces Multiple Presentations at the Upcoming Annual Meeting of The European Society of Gene and Ce...

                            Details : AMT-240 is a one-time-administered gene therapy using uniQure’s miQURE gene-silencing technology to silence the toxic APOE variant, in combination with overexpressing a protective APOE variant as treatment for autosomal dominant Alzheimer’s disease p...

                            Product Name : AMT‑240

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            November 10, 2022

                            Lead Product(s) : AMT‑240

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Intravacc

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                            Intravacc

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : European Union

                            Deal Size : $2.5 million

                            Deal Type : Funding

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                            DZNE and Intravacc Awarded EU Funding to Develop Vaccine Against Genetic ALS Variant

                            Details : DZNE developed an experimental vaccine that instructs the immune system to produce antibodies against these harmful poly-GA molecules. In a mouse model, this reduces poly-GA aggregates and largely prevents motor deficits.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            June 07, 2022

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : European Union

                            Deal Size : $2.5 million

                            Deal Type : Funding

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                            06

                            VectorY

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                            Lead Product(s) : VTx-002

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            VectorY Announces Preclinical Data on TDP-43 and Oxidized Phospholipids at American Society of Gene and Cell T...

                            Details : VTx-002, reduce TDP-43 pathological aggregates for treating ALS, TAR-DNA binding protein-43 is necessary for correct processing and transport of multiple mRNA’s that are essential for neuronal survival.

                            Product Name : VTx-002

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            May 18, 2022

                            Lead Product(s) : VTx-002

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            VectorY

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                            VectorY

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                            Lead Product(s) : AAV-VecTabs

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            VectorY Presents New Pre-clinical data at the European Network for the Cure of ALS (ENCALS)

                            Details : The new data demonstrate therapeutic potential and versatility of VectorY’s VecTab platform technology, enabling development of secreted or intracellular antibody fragments that are AAV-VecTabs delivered to neurons and/or astrocytes, in vitro and in vi...

                            Product Name : AAV-VecTabs

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            February 06, 2022

                            Lead Product(s) : AAV-VecTabs

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Uniqure

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                            Uniqure

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                            Lead Product(s) : AMT-210

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            uniQure Announces Multiple Presentations at Upcoming American Society of Gene and Cell Therapy (ASGCT) Annual ...

                            Details : AMT-210 (miRNA-based AAV Gene Therapy) is a one-time, brain-targeting AAV gene therapy incorporating miQURE gene silencing technology, designed to halt misfolded alpha-synuclein and subsequent fibril formation in familial and sporadic Parkinson’s disea...

                            Product Name : AMT-210

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            February 05, 2022

                            Lead Product(s) : AMT-210

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            VectorY

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                            VectorY

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Forbion

                            Deal Size : $36.7 million

                            Deal Type : Financing

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                            VectorY Raises €31 Million in Seed Financing to Develop Next-Generation Gene Therapies Aimed at Muscular and...

                            Details : Proceeds to establish pre-clinical proof of concept for vectorized antibodies in ALS and Alzheimer’s and to further expand the team.

                            Product Name : Undisclosed

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            June 15, 2021

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Forbion

                            Deal Size : $36.7 million

                            Deal Type : Financing

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