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Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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            Lead Product(s): PRAX-562

            Therapeutic Area: Neurology Product Name: PRAX-562

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Praxis Precision Medicines

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Partnership February 16, 2021

            Details:

            Praxis will utilize the Ciitizen platform to provide deeper insights across disease populations through the analysis of real-world data, initially to inform the development of PRAX-222 and PRAX-562 in SCN2A developmental and epileptic encephalopathy (SCN2A-DEE).

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            Lead Product(s): AK1780

            Therapeutic Area: Neurology Product Name: AK1780

            Highest Development Status: Phase I Product Type: Undisclosed

            Partner/Sponsor/Collaborator: Eli Lilly

            Deal Size: $410.0 million Upfront Cash: $20.0 million

            Deal Type: Licensing Agreement January 29, 2021

            Details:

            Lilly will be responsible for future global development and regulatory activities for AK1780. AK1780 is an orally bioavailable P2X7 receptor antagonist that recently completed Phase 1 single and multiple ascending dose and clinical pharmacology studies.

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            Lead Product(s): HTL0018318

            Therapeutic Area: Neurology Product Name: HTL0018318

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Allergan Plc

            Deal Size: $3,290.0 million Upfront Cash: $125.0 million

            Deal Type: Terminated January 05, 2021

            Details:

            AbbVie has notified that it will be returning to Sosei Heptares all assets in development under the program including HTL0018318, all intellectual property licensed by Sosei Heptares to Allergan, and all clinical and preclinical data generated under the partnership.

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            Lead Product(s): HTL0014242

            Therapeutic Area: Neurology Product Name: TMP-301

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Aditum Bio

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement November 02, 2020

            Details:

            Tempero Bio will obtain exclusive global rights to a portfolio of potent, orally available metabotropic glutamate receptor 5 NAM modulators, including HTL0014242, which were precision-designed by Sosei Heptares using its GPCR Structure-Based Drug Design (SBDD) platform.