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    [{"orgOrder":0,"company":"BenevolentAI","sponsor":"The Sheffield Institute for Translational Neuroscience","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"BEN-34712","moa":"Undisclosed","graph1":"Neurology","graph2":"IND Enabling","graph3":"BenevolentAI","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral","sponsorNew":"BenevolentAI \/ The Sheffield Institute for Translational Neuroscience","highestDevelopmentStatusID":"5","companyTruncated":"BenevolentAI \/ The Sheffield Institute for Translational Neuroscience"},{"orgOrder":0,"company":"GSK","sponsor":"SciNeuro Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2022","type":"Licensing Agreement","leadProduct":"SNP318","moa":"Lp-PLA2","graph1":"Neurology","graph2":"IND Enabling","graph3":"GSK","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"GSK \/ SciNeuro Pharmaceuticals","highestDevelopmentStatusID":"5","companyTruncated":"GSK \/ SciNeuro Pharmaceuticals"},{"orgOrder":0,"company":"Spur Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"UNITED KINGDOM","productType":"Cell and Gene therapy","year":"2024","type":"Inapplicable","leadProduct":"SPR301","moa":"GCase85","graph1":"Neurology","graph2":"IND Enabling","graph3":"Spur Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Spur Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Spur Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Pheno Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"PTD802","moa":"GPR17","graph1":"Neurology","graph2":"IND Enabling","graph3":"Pheno Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pheno Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Pheno Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"4D Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"UNITED KINGDOM","productType":"Microorganism","year":"2022","type":"Inapplicable","leadProduct":"MRx0005","moa":"IL-6 receptor","graph1":"Neurology","graph2":"IND Enabling","graph3":"4D Pharma","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral","sponsorNew":"4D Pharma \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"4D Pharma \/ Inapplicable"}]

    Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                            01

                            Pheno Therapeutics

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                            Pheno Therapeutics

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                            Lead Product(s) : PTD802

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Pheno Gets Clinical Trial Authorization for PTD802 in Multiple Sclerosis

                            Details : PTD802 is a novel small molecule therapeutic designed to promote remyelination by inhibiting GPR17. It is being investigated for multiple sclerosis.

                            Product Name : PTD802

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 14, 2025

                            Lead Product(s) : PTD802

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Spur Therapeutics

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                            Spur Therapeutics

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                            Lead Product(s) : SPR301

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Spur Therapeutics Develops Gene Therapy Candidate for Parkinson’s Disease

                            Details : SPR301 is an AAV9 capsid which can counteract the reduced GCase activity caused by these mutations, potentially providing a gene therapy that changes the lives of people with GBA1 Parkinson’s disease.

                            Product Name : SPR301

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            December 03, 2024

                            Lead Product(s) : SPR301

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Tiziana Life Sciences

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                            Tiziana Life Sciences

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                            Lead Product(s) : Foralumab

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Tiziana Doses First Patient with Moderate Alzheimer’s Disease with Foralumab

                            Details : Tiziana’s intranasal TZLS-401 (foralumab), is the only fully human anti-CD3 mAb that is being evaluated in patients with moderate Alzheimer’s disease.

                            Product Name : TZLS-401

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            June 26, 2024

                            Lead Product(s) : Foralumab

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            OKYO Pharma

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                            OKYO Pharma

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                            Lead Product(s) : Urcosimod

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            OKYO Pharma Announces Filing of an Investigational New Drug (IND) Application for OK-101 to Treat Neuropathic ...

                            Details : OK-101 is a lipid conjugated chemerin peptide antagonist of the ChemR23 G-protein coupled receptor which is typically found on immune cells of the eye responsible for the inflammatory response to treat Neuropathic Corneal Pain.

                            Product Name : OK-101

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            September 10, 2023

                            Lead Product(s) : Urcosimod

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Tiziana Life Sciences

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                            Tiziana Life Sciences

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                            Lead Product(s) : Foralumab

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Tiziana Life Sciences Announces FDA IND Clearance of Intranasal Foralumab for the Treatment of Alzheimer's Dis...

                            Details : Tiziana’s intranasal TZLS-401 (foralumab), is the only fully human anti-CD3 mAb and has demonstrated a favorable safety profile and clinical response in patients with alzheimer’s disease.

                            Product Name : TZLS-401

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            August 15, 2023

                            Lead Product(s) : Foralumab

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            OKYO Pharma

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                            OKYO Pharma

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                            Lead Product(s) : Urcosimod

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Tufts Medical Center

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            OKYO Pharma Plans to Initiate Phase 2 Trial of OK-101 in Neuropathic Corneal Pain (“NCP”) Following Announ...

                            Details : The agreement aims to evaluate the efficacy and safety of OK-101, a lipid conjugated chemerin peptide agonist of the ChemR23 G-protein coupled receptor, in patients with neuropathic corneal pain.

                            Product Name : OK-101

                            Product Type : Peptide

                            Upfront Cash : Undisclosed

                            July 28, 2023

                            Lead Product(s) : Urcosimod

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Tufts Medical Center

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            07

                            Mission Therapeutics

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                            Mission Therapeutics

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                            Lead Product(s) : MTX325

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Mission Therapeutics Granted MHRA Clinical Trial Authorisation (CTA) for MTX325 for the Treatment of Parkinson...

                            Details : MTX325 is a USP30 inhibitor small molecule drug candidate, which is currently being evaluated in clinical trial studies with patients for the treatment of parkinson's disease.

                            Product Name : MTX325

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 12, 2023

                            Lead Product(s) : MTX325

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            BenevolentAI

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                            EPS
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                            BenevolentAI

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                            EPS
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                            Lead Product(s) : BEN-34712

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : The Sheffield Institute for Translational Neuroscience

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            BenevolentAI Progresses BEN-34712 for the Potential Treatment of ALS into IND-Enabling Studies

                            Details : BEN-34712 is an oral, potent and selective brain penetrant RARɑβ (retinoic acid receptor alpha beta) biased agonist and will now enter investigational new drug (IND)-enabling studies for amyotrophic lateral sclerosis.

                            Product Name : BEN-34712

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 06, 2023

                            Lead Product(s) : BEN-34712

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : The Sheffield Institute for Translational Neuroscience

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            4D Pharma

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                            4D Pharma

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                            Lead Product(s) : MRx0005

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            4D Pharma Announces FDA Clearance of IND Application for Live Biotherapeutics MRx0005 and MRx0029 for the Trea...

                            Details : IND clearance marks the expansion of the comany's pipeline single strain Live Biotherapeutics of MRx0005 and MRx0029 in development for the treatment of neurodegenerative conditions such as Parkinson’s disease via the gut-brain axis.

                            Product Name : MRx0005

                            Product Type : Microorganism

                            Upfront Cash : Inapplicable

                            February 22, 2022

                            Lead Product(s) : MRx0005

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            GSK

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                            GSK

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                            Lead Product(s) : SNP318

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : SciNeuro Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            SciNeuro Pharmaceuticals Announces a License and Option Agreement with GSK to Progress Development of Novel Th...

                            Details : Under the agreement, SciNeuro will receive a worldwide license to intellectual property covering certain GSK Lp-PLA2 inhibitors including SNP318 and will be responsible for their further development through clinical proof-of-concept (PoC).

                            Product Name : SNP318

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 06, 2022

                            Lead Product(s) : SNP318

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : SciNeuro Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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