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    [{"orgOrder":0,"company":"Spur Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"UNITED KINGDOM","productType":"Cell & Gene Therapy","year":"2024","type":"Inapplicable","leadProduct":"SPR301","moa":"GCase85","graph1":"Neurology","graph2":"IND Enabling","graph3":"Spur Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Spur Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Spur Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Pheno Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"UNITED KINGDOM","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"PTD802","moa":"GPR17","graph1":"Neurology","graph2":"IND Enabling","graph3":"Pheno Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pheno Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Pheno Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"4D Pharma","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"UNITED KINGDOM","productType":"Microorganism","year":"2022","type":"Inapplicable","leadProduct":"MRx0005","moa":"IL-6 receptor","graph1":"Neurology","graph2":"IND Enabling","graph3":"4D Pharma","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"4D Pharma \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"4D Pharma \/ Undisclosed"},{"orgOrder":0,"company":"GSK","sponsor":"SciNeuro Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"UNITED KINGDOM","productType":"Miscellaneous","year":"2022","type":"Licensing Agreement","leadProduct":"SNP318","moa":"Lp-PLA2","graph1":"Neurology","graph2":"IND Enabling","graph3":"GSK","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"GSK \/ SciNeuro Pharmaceuticals","highestDevelopmentStatusID":"5","companyTruncated":"GSK \/ SciNeuro Pharmaceuticals"},{"orgOrder":0,"company":"NRG Therapeutics","sponsor":"Michael J. Fox Foundation for Parkinson\u2019s Research","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"UNITED KINGDOM","productType":"Miscellaneous","year":"2024","type":"Funding","leadProduct":"NRG5051","moa":"Undisclosed","graph1":"Neurology","graph2":"IND Enabling","graph3":"NRG Therapeutics","amount2":0.01,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0.01,"dosageForm":"Undisclosed","sponsorNew":"NRG Therapeutics \/ Michael J. Fox Foundation for Parkinson\u2019s Research","highestDevelopmentStatusID":"5","companyTruncated":"NRG Therapeutics \/ Michael J. Fox Foundation for Parkinson\u2019s Research"},{"orgOrder":0,"company":"NRG Therapeutics","sponsor":"SV Health Investors","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"UNITED KINGDOM","productType":"Miscellaneous","year":"2025","type":"Series B Financing","leadProduct":"NRG5051","moa":"mPTP","graph1":"Neurology","graph2":"IND Enabling","graph3":"NRG Therapeutics","amount2":0.070000000000000007,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0.070000000000000007,"dosageForm":"Undisclosed","sponsorNew":"NRG Therapeutics \/ SV Health Investors","highestDevelopmentStatusID":"5","companyTruncated":"NRG Therapeutics \/ SV Health Investors"},{"orgOrder":0,"company":"BenevolentAI","sponsor":"The Sheffield Institute for Translational Neuroscience","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"UNITED KINGDOM","productType":"Miscellaneous","year":"2023","type":"Inapplicable","leadProduct":"BEN-34712","moa":"Undisclosed","graph1":"Neurology","graph2":"IND Enabling","graph3":"BenevolentAI","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"BenevolentAI \/ The Sheffield Institute for Translational Neuroscience","highestDevelopmentStatusID":"5","companyTruncated":"BenevolentAI \/ The Sheffield Institute for Translational Neuroscience"}]

    Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                            01

                            NRG Therapeutics

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed

                            NRG Therapeutics

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                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : NRG5051

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : SV Health Investors

                            Deal Size : $67.0 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            NRG Therapeutics Announces Oversubscribed Series B Financing

                            Details : The financing will enable NRG Therapeutics to deliver clinical proof of concept in ALS/MND with NRG5051, a first-in-class, oral inhibitor of the mitochondrial permeability transition pore (mPTP).

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            September 08, 2025

                            Lead Product(s) : NRG5051

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : SV Health Investors

                            Deal Size : $67.0 million

                            Deal Type : Series B Financing

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                            02

                            Pheno Therapeutics

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed

                            Pheno Therapeutics

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                            OTS 2025
                            Not Confirmed
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                            • EDQM
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                            Lead Product(s) : PTD802

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Pheno Gets Clinical Trial Authorization for PTD802 in Multiple Sclerosis

                            Details : PTD802 is a novel small molecule therapeutic designed to promote remyelination by inhibiting GPR17. It is being investigated for multiple sclerosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            January 14, 2025

                            Lead Product(s) : PTD802

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Spur Therapeutics

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed

                            Spur Therapeutics

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : SPR301

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Spur Therapeutics Develops Gene Therapy Candidate for Parkinson’s Disease

                            Details : SPR301 is an AAV9 capsid which can counteract the reduced GCase activity caused by these mutations, potentially providing a gene therapy that changes the lives of people with GBA1 Parkinson’s disease.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            December 03, 2024

                            Lead Product(s) : SPR301

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Tiziana Life Sciences

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed

                            Tiziana Life Sciences

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Foralumab

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Tiziana Doses First Patient with Moderate Alzheimer’s Disease with Foralumab

                            Details : Tiziana’s intranasal TZLS-401 (foralumab), is the only fully human anti-CD3 mAb that is being evaluated in patients with moderate Alzheimer’s disease.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            June 26, 2024

                            Lead Product(s) : Foralumab

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Mission Therapeutics

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed

                            Mission Therapeutics

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : MTX325

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Mission Therapeutics Granted MHRA Clinical Trial Authorisation (CTA) for MTX325 for the Treatment of Parkinson...

                            Details : MTX325 is a USP30 inhibitor small molecule drug candidate, which is currently being evaluated in clinical trial studies with patients for the treatment of parkinson's disease.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 05, 2023

                            Lead Product(s) : MTX325

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Tiziana Life Sciences

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed

                            Tiziana Life Sciences

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Foralumab

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Tiziana Life Sciences Announces FDA IND Clearance of Intranasal Foralumab for the Treatment of Alzheimer's Dis...

                            Details : Tiziana’s intranasal TZLS-401 (foralumab), is the only fully human anti-CD3 mAb and has demonstrated a favorable safety profile and clinical response in patients with alzheimer’s disease.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            August 15, 2023

                            Lead Product(s) : Foralumab

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            BenevolentAI

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed

                            BenevolentAI

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : BEN-34712

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : The Sheffield Institute for Translational Neuroscience

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            BenevolentAI Progresses BEN-34712 for the Potential Treatment of ALS into IND-Enabling Studies

                            Details : BEN-34712 is an oral, potent and selective brain penetrant RARɑβ (retinoic acid receptor alpha beta) biased agonist and will now enter investigational new drug (IND)-enabling studies for amyotrophic lateral sclerosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            June 03, 2023

                            Lead Product(s) : BEN-34712

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : The Sheffield Institute for Translational Neuroscience

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            GSK

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed

                            GSK

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : SNP318

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : SciNeuro Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            SciNeuro Pharmaceuticals Announces a License and Option Agreement with GSK to Progress Development of Novel Th...

                            Details : Under the agreement, SciNeuro will receive a worldwide license to intellectual property covering certain GSK Lp-PLA2 inhibitors including SNP318 and will be responsible for their further development through clinical proof-of-concept (PoC).

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            June 01, 2022

                            Lead Product(s) : SNP318

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : SciNeuro Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            09

                            4D Pharma

                            United Kingdom arrow
                            OTS 2025
                            Not Confirmed

                            4D Pharma

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                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : MRx0005

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            4D Pharma Announces FDA Clearance of IND Application for Live Biotherapeutics MRx0005 and MRx0029 for the Trea...

                            Details : IND clearance marks the expansion of the comany's pipeline single strain Live Biotherapeutics of MRx0005 and MRx0029 in development for the treatment of neurodegenerative conditions such as Parkinson’s disease via the gut-brain axis.

                            Product Name : Undisclosed

                            Product Type : Microorganism

                            Upfront Cash : Inapplicable

                            February 22, 2022

                            Lead Product(s) : MRx0005

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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