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Details:
The Company also confirmed in its own murine cortical neuron outgrowth preclinical study, that AP-188 (N,N-Dimethyltryptamine), in sub-psychedelic doses, increased the growth of cortical neurons by up to 40% compared to control.
Lead Product(s):
N,N-Dimethyltryptamine
Therapeutic Area: Neurology
Product Name: AP-188
Highest Development Status: IND Enabling
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
September 12, 2022
Details:
PMN310, is a monoclonal antibody for Alzheimer’s disease created with a novel, proprietary method for generating and developing antibodies that can uniquely and precisely target toxic forms of otherwise normal proteins.
Lead Product(s):
PMN310
Therapeutic Area: Neurology
Product Name: PMN310
Highest Development Status: IND Enabling
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
July 27, 2022
Details:
AP-188 (N,N-Dimethyltryptamine), or DMT, is a hallucinogenic tryptamine drug producing effects similar to those of other psychedelics like LSD, ketamine, psilocybin and psilocin.
Lead Product(s):
N,N-Dimethyltryptamine
Therapeutic Area: Neurology
Product Name: AP-188
Highest Development Status: IND Enabling
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
July 07, 2022
Details:
PMN310 is an antibody that binds to the neurotoxic amyloid beta aggregates, preventing additional amyloid beta monomers from adding to them. Therefore, PMN310 may potentially neutralize toxic aggregates and prevent neurodegeneration.
Lead Product(s):
PMN310
Therapeutic Area: Neurology
Product Name: PMN310
Highest Development Status: IND Enabling
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
May 17, 2022
Details:
PMN310, is a monoclonal therapeutic antibody designed for treatment of Alzheimer’s disease. By selectively targeting toxic oligomers of amyloid-beta, showed a significant cognitive benefit in a widely recognized animal model of AD.
Lead Product(s):
PMN310
Therapeutic Area: Neurology
Product Name: PMN310
Highest Development Status: IND Enabling
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
March 24, 2022
Details:
PMN310, a next-generation, potential best-in-class anti-amyloid therapy selectivity for toxic oligomer form of amyloid indicates that it possess features necessary to be considered a potentially treatment for AD.
Lead Product(s):
PMN310
Therapeutic Area: Neurology
Product Name: PMN310
Highest Development Status: IND Enabling
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
March 22, 2022
Details:
APP/L mouse model of AD in which human amyloid-lead to cognitive deficits for PMN310, selectively targets toxic oligomers of amyloid-beta preserved memory using water maze readout, to extent that PMN310 treated mice were indistinguishable from “non-transgenic" control mice.
Lead Product(s):
PMN310
Therapeutic Area: Neurology
Product Name: PMN310
Highest Development Status: IND Enabling
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
March 02, 2022
Details:
A novel salt form of AP-188 (N, N-dimethyltryptamine), a hallucinogenic tryptamine drug, is a new and separate structure from the original compound, helps mitigate tissue damage and promote neurogenesis demonstrated in preclinical studies.
Lead Product(s):
N,N-Dimethyltryptamine
Therapeutic Area: Neurology
Product Name: AP-188
Highest Development Status: IND Enabling
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
January 24, 2022
Details:
Company received positive feedback from the UK MHRA for its planned Phase 1 DMT Stroke study for AP-188 (N,N-Dimethyltryptamine), a hallucinogenic tryptamine drug for the treatment of mental health disorders.
Lead Product(s):
N,N-Dimethyltryptamine
Therapeutic Area: Neurology
Product Name: AP-188
Highest Development Status: IND Enabling
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
January 19, 2022
Details:
The data showed that an increase in growth of over 40% was observed in the group treated for 6 hours with 30 nM AP-188 or DMT, with statistical significance, when compared to control. The results from the 6-hour period were superior to other treatment time periods and doses.
Lead Product(s):
N,N-Dimethyltryptamine
Therapeutic Area: Neurology
Product Name: AP-188
Highest Development Status: IND Enabling
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
November 01, 2021
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